Abstract
Cardiac transplantation in rats has been performed preferentially with models of empty beating hearts that were connected either to the neck vessels or to the abdominal aorta and vena cava. Whether this nonphysiological approach with altered coronary perfusion and proven functional impairments (Bernhard and Konertz 1983; Dittmer and Goss 1973) has any influence on the immunological behavior of the graft or the recipient is still unknown. On the other hand, orthotopic transplantation, which would be a very desirable procedure in rats, is troublesome to perform due to difficulties with extracorporeal circulation in such small animals (Konertz et al. 1979a). We introduced heterotopic thoracic transplantation as left ventricular bypass in rats (Konertz et al. 1979b,c,1980b). This superior procedure gives immunological and functional results under standardized and repeatable conditions. This paper will describe technical aspects of heart transplantation in rats.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Abbott CP, Lindsay ES, Creech 0, et al. (1974) Technique for heart transplantation in the rat. Arch Surg 89:645–652
Barnard CN (1976) Heterotopic versus orthotopic heart transplantation. Transplant Proc 8:15–19
Bernhard A, Konertz W (1983) Experimental heart transplantation. J Thorac Cardiovasc Surg 86:314
Dittmer JE, Goss RJ (1973) Size changes of auxiliary adult heart grafts in rats. Cardiology 58:355–363
Konertz W, Regensburger D, Semik M, et al. (1979 a) Heart transplantation in rats (Abstr). Transplant Proc 11:593
Konertz W, Semik M, Bernhard A (1979 b) Early postoperative pump performance of thoracic heterotopic cardiac grafts in rats (Abstr). Transplant Proc 11:592
Konertz W, Semik M, Bernhard A (1979 c) Early postoperative pump performance of thoracic cardiac grafts in rats (Abstr). J Mol Cell Cardiol 11:32
Konertz W, Thiede A, Bernhard A (1980 a) Heterotopic heart transplantation in rats - an improved technique of functional evaluation. Excerpta Med Int Congr Ser 465:359–361
Konertz W, Semik M, Bernhard A (1980 b) Left ventricular bypass in inbred rats - a new experimental model in microsurgery. Operative technique and hemodynamic evaluation. Thorac Cardiovasc Surg 28:277–279
Konertz W, Zaworka P, Johanson W, et al. (1982) 24 hours heart preservation with modified Eurocollins Solution. In: Belenger J (ed) Life support systems. Proceedings of the 9th annual meeting of ESAO. Sounders, London, pp 151–152
Konertz W, Zaworka P, Johanson W, et al. (1983) 24 hours heart preservation. Heart Transplant 2:278–280
Losman J (1977) Review of the cape town experience with heterotopic cardiac transplant. Cardiovasc Dis 4:243–255
Losman J (1978) Cardiac surgical research and heart transplantation in Papio ursinus. J S Afr Vet Assoc 49:211–215
W. Konertz, M. Semik, and A. Bernhard: Heart Transplantation in Rats Losman J, Barnard CN (1977) Hemodynamic evaluation of left ventricular bypass with a homologous cardiac graft. J Thorac Cardiovasc Surg 74:695–708
Martial BH, Armelin E, Stolf N, et al. (1972) Assisted circulation with an auxiliary heart transplant: an experimental study. J Thorac Cardiovasc Surg 63:696–704
Moore CH, Ross DN (1976) Experimental auxiliary heart transplantation for left ventricular assistance. Transplant Proc 8:41–44
Suros J, Woods JE (1973) Synchronized intrathoracic auxiliary heart transplantation in parallel. J Thorac Cardiovasc Surg 65:415–424
Yacoub MH, Rose ML, Fraser AK, et al. (1983) T-Cell phenotype characterization in human cardiac allografts. Heart Transplant 2:259–265
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin, Heidelberg
About this paper
Cite this paper
Konertz, W., Semik, M., Bernhard, A. (1985). Heart Transplantation in Rats. In: Thiede, A., Deltz, E., Engemann, R., Hamelmann, H. (eds) Microsurgical Models in Rats for Transplantation Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61657-0_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-61657-0_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-64899-1
Online ISBN: 978-3-642-61657-0
eBook Packages: Springer Book Archive