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Immunogenetic Aspects of Organ Transplantaion in the Rat

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Book cover Microsurgical Models in Rats for Transplantation Research

Abstract

In this contribution some genetic aspects will be discussed which are relevant when organ studying graft rejection in the rat. The more general considerations will be illustrated mainly by results in the production of which the author has been involved, and no review (Günther and Štark 1977) of the literature is intended.

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References

  • Barclay AN, Mason DW, Mayrhofer G (1983) The distribution of la antigens in the rat. Transplant Proc 15:1587–1588

    Google Scholar 

  • Begovich AB, Blankenhorn EP, Winters BA (1983) Genetic control of the expression of class I molecules on rat erythrocytes. Immunogenetics 18:45–56

    Article  PubMed  CAS  Google Scholar 

  • Blankenhorn EP, Symington FW, Cramer DV (1983) Biochemical characterization of la antigens encoded by the RTLB and RTLD loci in the rat MHC. Immunogenetics 17:475–484

    Article  PubMed  CAS  Google Scholar 

  • Butcher GW, Howard JC (1977) A recombinant in the major histocompatibility complex of the rat. Nature 266:362–364

    Article  PubMed  CAS  Google Scholar 

  • Butcher GW, Howard JC (1982) Genetic control of transplant rejection. Transplantation 34:161–166

    Article  PubMed  CAS  Google Scholar 

  • Butcher GW, Corvalan JR, Licence DR, Howard JC (1982) Immune response genes controlling responsiveness to major transplantation antigens. Specific major histocompatibility complex-linked defect for antibody responses to class I alloantigens. J Exp Med 155:303–320

    Article  PubMed  CAS  Google Scholar 

  • Dallmann MJ, Mason DW (1983) Cellular mechanism of skin allograft rejection in the rat. Transplant Proc 15:335–338

    Google Scholar 

  • Fabre JW (1982) Rat kidney allograft model: Was it all too good to be true? Transplantation 34:223–225

    Article  PubMed  CAS  Google Scholar 

  • Gazit E, Terhorst C, Yunis EJ (1980) The human “T” genetic region of the HLA linkage group is a polymorphism detected on lectin-activated lymphocytes. Nature 284:275–277

    Google Scholar 

  • Günther E, Štark O (1977) The major histocompatibility system of the rat (Ag-B or H-1 system). In: Gbtze D (ed) The major histocompatibility system in man and animals. Springer, Berlin Heidelberg New York, pp 207–253

    Google Scholar 

  • Günther E, Štark O (1978) At least two loci of the major histocompatibility complex can determine mixed lymphocyte stimulation in the rat. Tissue Antigens 11:465–470

    Article  PubMed  Google Scholar 

  • Günther E, Wurst W (1984) Cytotoxic T lymphocytes of the rat are predominantly restricted by RTLA and not RTI.C — determined major histocompatibility class T antigens. Immunogenetics 20:1–12

    Article  PubMed  Google Scholar 

  • Günther E, Štark U, Koch C (1978) Genetic definition of I region-determined antigens of the rat major histocompatibility complex. Eur J Immunol 8:206–212

    Article  PubMed  Google Scholar 

  • Haustein D, Günther E (1980) Biochemical analysis of gene products of major histocompatibility recombinant haplotypes in the rat. Eur J Immunol 10:615–620

    Article  PubMed  CAS  Google Scholar 

  • Haustein D, Stock W, Günther E (1982) Rat major histocompatibility RTLC antigens of restricted tissue distribution consist of two polypeptide chains with molecular weights of about 42 000 and 12 500. Immunogenetics 15:271–277

    Article  PubMed  CAS  Google Scholar 

  • Hendriks GFJ, Persijn GG, Lansbergen Q, D’Amaro JD, Schreuder GMT, Cohen B, Rood JJ van (1983) Excellent outcome after transplantation of renal allografts from HLADRw6-positive donors even in HLA-DR mismatches. Lancet 2:187–189

    Article  PubMed  CAS  Google Scholar 

  • Heslop BF, Jolly KD (1979) Genetic control of haemagglutinin production against an MHC determined alloantigen in rats. Immunogenetics 8:567–570

    Article  Google Scholar 

  • Hood L, Steinmetz M, Malissen B (1983) Genes of the major histocompatibility complex of the mouse. Annu Rev Immunol 1:529–658

    Article  PubMed  CAS  Google Scholar 

  • Howard JC, Butcher GW, Galfré G, Milstein C, Milstein CP (1979) Monoclonal antibodies as tools to analyse the serological and genetic complexities of major transplantation antigens. Immunol Rev 47:139–174

    CAS  Google Scholar 

  • Klein J (1982) Evolution and function of the major histocompatibility complex. In: Parham P, Strominger J (eds) Histocompatibility antigens: structure and function. Chapman and Hall, London, pp 223–239 (Receptors and recognition. Series B, vol 14

    Google Scholar 

  • Klein J, Figueroa F, Nagy ZA (1983) Genetics of the major histocompatibility complex: the final act. Annu Rev Immunol 1:119–142

    Article  PubMed  CAS  Google Scholar 

  • Klempnauer J, Wonigeit K, Günther E, Pichlmayr R (1983 a) Pancreas whole organ transplantation in the rat. Evidence for a strong effect of non-MHC incompatibilities. Transplant Proc 15:1649–1651

    Google Scholar 

  • Klempnauer J, Wonigeit K, Steiniger B, Günther E, Pichlmayr R (1983 b) Pancreas whole organ transplantation in the rat. Differential effect of individual MHC regions. Transplant Proc 15:1308–1310

    Google Scholar 

  • Kohoutovd M, Mark 0 (1981) A new congenic strain LEW.C4H with a weak H-locus. Transplant Proc 13:1319–1320

    Google Scholar 

  • Kohoutovd M, Günther E, Mark O (1980) Genetic definition of a further gene region and identification of at least three different histocompatibility genes in the rat major histocompatibility system. Immunogenetics 11:483–490

    Article  Google Scholar 

  • Křen V, Bílá V, Kršiaková M (1978) Alleles of the H-5 locus linked tolx locus in different rat strains. Folio Biol 24:376–377

    Google Scholar 

  • Kunz HW, Gill TJ III, Dixon BD, Taylor FH, Greiner DC (1980) The growth and reproduction complex in the rat: genes linked to the major histocompatibility complex which affect development. J Exp Med 152:1506–1518

    Article  PubMed  CAS  Google Scholar 

  • Kunz HW, Gill TJ III, Misra DN (1982) The identification and mapping of a second class I locus in the major histocompatibility complex of the rat. J Immunol 128:402–408

    PubMed  CAS  Google Scholar 

  • Livingstone AM, Butcher GW, Howard JC (1983) Recombination within the MHC can change the specificity of class I major transplantation antigens. Transplant Proc 15:1557–1559

    Google Scholar 

  • Lobel SA, Comer DV (1981) Demonstration of a new genetic locus in the major histocompatibility system of the rat. Immunogenetics 13:465–473

    Article  PubMed  CAS  Google Scholar 

  • Loveland BE, McKenzie IFC (1982) Which T cells cause graft rejection? Transplantation 33:217–221

    PubMed  CAS  Google Scholar 

  • Lowry RP, Gurley KE (1983) Rejection of organ allografts transplanted across MHC subregion disparity (RTI.B). Transplant Proc 15:1643–1646

    Google Scholar 

  • Mason DW, Dallmann M, Barclay AN (1981) Graft-versus-host disease induces expression of la antigens in rat epidermal cells and gut epithelium. Nature 293:150–151

    Article  PubMed  CAS  Google Scholar 

  • Mullen Y, Hildemann WH (1972) X- and Y-linked transplantation antigens in rats. Transplantation 13:521–529

    Article  PubMed  CAS  Google Scholar 

  • Nesbitt MN (1974) Evolutionary relationship between rat and mouse chromosomes. Chromosoma 46:217–224

    Article  PubMed  CAS  Google Scholar 

  • Orr H (1982) The major histocompatibility complex: analysis at the protein and DNA levels. In: Parham P, Strominger J (eds) Histocompatibility antigens: structure and function. Chapman and Hall, London, pp 3–51 (Receptors and recognition. Series B, vol 14

    Google Scholar 

  • Paris A, Günther E (1980) Kidney grafting between rats which carry recombinant major histocompatibility haplotypes. Immunogenetics 10:205–209

    Article  Google Scholar 

  • Paris A, Bishop C, Festenstein H, Günther E (1978) Non-major histocompatibility system immunogenetic influences in rat renal allograft survival. Transplantation 25:252–254

    Article  Google Scholar 

  • Paul LC, Carpenter CB (1983) Non-MHC transplantation antigens in the rat. Transplant Proc 15:217–219

    Google Scholar 

  • Paul LC, Paradysz JM, Milford EL, Kunz HW, Carpenter CB (1982) Expression of RT LA and RTLB/D antigens on endothelium of rat kidneys. Transplantation 34:121–128

    Article  PubMed  CAS  Google Scholar 

  • Rozing J, Bonthuis P, Joling P, Vaessen LMB, Lameijer LDF (1983) The influence of RT I. subregion differences on cardiac allograft survival. Transplant Proc 15:1647–1648

    Google Scholar 

  • Soulillou JP, Blandin F, Günther E, Lemoine V (1984) Genetics of the blood transfusion effect on heart allografts in rats. Transplantation 38:63–67

    Article  PubMed  CAS  Google Scholar 

  • Štark O, Günther E, Kohoutovd M, Vojčik L (1977) Genetic recombination in the major histocompatibility complex (H-1,Ag-B) of the rat. Immunogenetics 5:183–187

    Article  Google Scholar 

  • Stock W, Günther E (1982) Serologic and cellular characterization of products of a new major histocompatibility gene region, RTI.C, of the rat; possible homology to mouse H-2Qa. J Immunol 128:1923–1928

    PubMed  CAS  Google Scholar 

  • Stolc V, Kunz HW, Gill TJ III (1980) The linkage of glyoxalase I to the major histocompatibility complex in the rat. J Immunol 125:1167–1170

    PubMed  CAS  Google Scholar 

  • VandeBerg JC, Bittner GN, Meyer GS, Kunz HW, Gill TJ III (1981) Linkage of neuraminidase and α-mannosidase to the major histocompatibility complex in the rat. J Immunogenet 8:239–242

    Article  PubMed  CAS  Google Scholar 

  • Zimmermann FA, Knoll PP, Davies H ffS, Gokel JM, Schmid T (1983) The fate of orthotopic liver allografts in different rat strain combinations. Transplant Proc 15:1272–1275

    Google Scholar 

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Authors
  1. E. Günther
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Editors and Affiliations

  1. Abteilung Allgemeine Chirurgie, Chirurgische Universitätsklinik, Hospitalstrasse 40, D-2300, Kiel 1, Federal Republic of Germany

    Arnulf Thiede , Eberhard Deltz , Rainer Engemann  & Horst Hamelmann , ,  & 

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© 1985 Springer-Verlag Berlin, Heidelberg

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Günther, E. (1985). Immunogenetic Aspects of Organ Transplantaion in the Rat. In: Thiede, A., Deltz, E., Engemann, R., Hamelmann, H. (eds) Microsurgical Models in Rats for Transplantation Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61657-0_14

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  • DOI: https://doi.org/10.1007/978-3-642-61657-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64899-1

  • Online ISBN: 978-3-642-61657-0

  • eBook Packages: Springer Book Archive

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