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Sandostatin® in the Treatment of Gastroenteropancreatic Endocrine Tumors pp 59–60Cite as

Rebound Effect and Escape of Diarrhea Inhibition Using Sandostatin® in VIPoma Patients

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Abstract

We report here on two patients treated with Sandostatin® (octreotide) for pancreatic cholera due to metastatic VIPoma. After good initial responses, the inhibitory effect of Sandostatin (SMS) on diarrhea and VIP release disappeared and a significant rebound state developed while the treatment continued.

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References

  1. Ekelund M., Ekman R., Hakanson R., Sundler F.: Continuous infusion of somatostatin evokes escape of gastric acid inhibition in the rat. Gastroenterology 1984, 86:861–865

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  2. Koelz A., Kraenzlin M., Gyr K., Meier V., Bloom St. R., Heitz Ph., Stalder H.: Escape of the response to a long-acting somatostatin analogue (SMS 201–995) in patients with vipoma. Gastroenterology 1987, 92:527–531

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Author information

Authors and Affiliations

  1. Department of Internal Medicine, Kantonsspital Liestal, University of Basle, Liestal, Switzerland

    K. Gyr, A. Koelz, M. Kraenzlin, C. Beglinger, V. Meier & S. R. Bloom

  2. Department of Endocrinology, Hammersmith Hospital, London, UK

    K. Gyr, A. Koelz, M. Kraenzlin, C. Beglinger, V. Meier & S. R. Bloom

Authors
  1. K. Gyr
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  2. A. Koelz
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  3. M. Kraenzlin
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  4. C. Beglinger
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  5. V. Meier
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  6. S. R. Bloom
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Editor information

Editors and Affiliations

  1. College of Medicine, Department of Endocrinology, The Ohio State University, 410 West 10th Street, Columbus, Ohio, 43210, USA

    T. M. O’Dorisio M. D.

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© 1989 Springer Verlag, Berlin Heidelberg

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Cite this paper

Gyr, K., Koelz, A., Kraenzlin, M., Beglinger, C., Meier, V., Bloom, S.R. (1989). Rebound Effect and Escape of Diarrhea Inhibition Using Sandostatin® in VIPoma Patients. In: O’Dorisio, T.M. (eds) Sandostatin® in the Treatment of Gastroenteropancreatic Endocrine Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61328-9_9

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  • DOI: https://doi.org/10.1007/978-3-642-61328-9_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64794-9

  • Online ISBN: 978-3-642-61328-9

  • eBook Packages: Springer Book Archive

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