Abstract
c-myc mRNA contains at least two discrete sequence elements that account for its short half-life, one in the 3′-untranslated region, the other in the carboxy terminal coding region (coding region determinant). A combination of experiments with cell-free extracts and intact cells suggests that the coding region determinant interacts with an abundant RNA-binding protein that, when bound to the mRNA, protects it from endonucleolytic attack. The mRNA-protein complex might serve as a fail-safe mechanism to permit rapid c-myc mRNA destruction at certain times.
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© 1996 Springer-Verlag Berlin Heidelberg
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Ross, J., Bernstein, P., Prokipcak, R.D., Herrick, D.J. (1996). Regulation of c-myc mRNA Half-Life by an RNA-Binding Protein. In: Tsiftsoglou, A.S., Sartorelli, A.C., Housman, D.E., Dexter, T.M. (eds) Tumor Biology. NATO ASI Series, vol 99. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61180-3_24
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DOI: https://doi.org/10.1007/978-3-642-61180-3_24
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