Abstract
Glucagon is a polypeptide hormone well known for its effects on glucose and lipid metabolism. Once thought to be primarily a hyperglycemic factor, glucagon is now known to alter physiologic function in many tissues. This chapter reviews the use of pharmacologic quantities of glucagon in the treatment of diseases which affect critically ill patients (Table 1).
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References
Abel FL (1983) Action of glucagon on canine left ventricular performance and coronary hemodynamics. Circ Shock 11:45
Abernethy WB, Butterworth JF, Prielipp RC, Leith JP, Zaloga GP (1995) Calcium entry attenuates adenylyl cyclase activity: a possible mechanism for calcium-induced catecholamine resistance. Chest 107:1420–1425
Achord JL (1993) Review of alcoholic hepatitis and its treatment. Am J Gastroenterol 88:1822–1831
Agura ED, Wexler LF, Witzburg RA (1986) Massive propranolol overdose: successful treatment with high-dose isoproterenol and glucagon. Am J Med 80:755
Aki Y, Shoji T, Hasui K, Fukui K, Tamaki T, Iwao H, Abe Y (1990) Intrarenal vascular sites of action of adenosine and glucagon. Jpn J Pharmacol 54:433
Almy TP, Howell DA (1980) Diverticular disease of the colon. N Engl J Med 302:324–331
Andjelkovic I, Zlokovic B (1982) Protective effects of glucagon during the anaphylactic response in guinea-pig isolated heart. Br J Pharmacol 76:483
Bahn Zobbe V, Rygaard H, Rasmussen D, Strandberg C, Krause S, Hartvig Hartsen S, Thomsen HS (1986) Glucagon in acute ureteral colic: a randomized trial. Eur Urol 12:28–31
Baker AL (1993) Glucagon for the management of hepatic emergencies. In: Picazo J (ed) Glucagon in acute medicine. Kluwer Academic, Dordrecht, p 131
Baker AL, Jaspan JB, Haines NW, Hatfield GE, Krager PS, Schneider JF (1981) A randomized clinical trial of insulin and glucagon infusion for treatment of alcoholic hepatitis: progress report in 50 patients. Gastroenterology 80:1410–1414
Barritt GJ, Spiel PF (1981) Effects of glucagon on 45Ca outflow exchange in the isolated perfused rat heart. Biochem Pharmacol 30:1407
Berggreen PJ, Harrison E, Sanowski RA, Ingebo K, Noland B, Zierer S (1993) Techniques and complications of esophageal foreign body extraction in children and adults. Gastrointest Endosc 39:626–630
Berk JL (1976) Non-occlusive mesenteric vascular insufficiency. Arch Surg 111:829–830
Bird G, Lau JY, Koskinas J, Wicks C, Williams R (1991) Insulin and glucagon infusion in acute alcoholic hepatitis: a prospective randomized controlled trial. Hepatology 14:1097–1101
Blumenthal MN, Brody TM (1969) Studies on the mechanism of drug-induced bronchiolar relaxation in the guinea pig. J Allergy 44:63–69
Boder GB, Johnson IS (1972) Comparative effects of some cardioactive agents on the automaticity of cultured heart cells. J Mol Cell Cardiol 4:453
Bond JH, Levitt MD (1979) Use of microspheres to measure small intestinal villus blood flow in the dog. Am J Physiol 236:577
Bond JH, Levitt MD (1980) Effect of glucagon on gastrointestinal blood flow of dogs in hypovolemic shock. Am J Physiol 238:G434
Boorstein JM, Dacey LJ, Cronenwett JL (1988) Pharmacologic treatment of occlusive mesenteric ischemia in rats. J Surg Res 44:555–560
Bower MG, Okude S, Jolley WB, Smith LL (1970) Hemodynamic effects of glucagon following hemorrhagic and entotoxic shock in the dog. Arch Surg 101:411–415
Bowman HM, Cowan D, Kovach G Jr, Hook JB (1972) Renal effects of glucagon in rhesus monkeys during hypovolemia. Surg Gynecol Obstet 134:937–941
Brandstatter G, Kratochvil P (1979) Glucagon ber gallenkoliken. Therapiewoche 29:3362–3365
Brogan E, Kozonis MC, Overy DC (1969) Glucagon therapy in heart failure. Lancet 1:482
Carr-Locke DL (1993) Biliary and pancreatic emergencies. In: Picazo J (ed) Glucagon in acute medicine. Kluwer Academic, Dordrecht, p 141
Carsen GM, Finby N (1976) Hypotonic duodenography with glucagon. A clinical comparison study. Radiology 118:529
Chernow B, Reed L, Geelhoed GW, Anderson M, Teich S, Meyerhoff J, Beardsley D, Lake CR, Holaday JW (1986) Glucagon: endocrine effects and calcium involvement in cardiovascular actions in dogs. Circ Shock 19:393
Chernow B, Zaloga GP, Malcolm D, Willey SC, Clapper M, Holaday JW (1987) Glucagon’s chronotropic action is calcium dependent. J Pharmacol Exp Ther 241:833
Chiou GCY, Chuang CY (1988) Treatment of hypoglycemia with glucagon eye drops. J Ocular Pharm 4:179
Clark ET, Gewertz BL (1990) Glucagon potentiates intestinal reperfusion injury. J Vasc Surg 11:270–279
Cohn KE, Agmon J, Gamble OW (1970) The effect of glucagon on arrhythmias to digitalis toxicity. Am J Cardiol 25:683
Collier A, Steedman DJ, Patrick AW, Nimmo GR, Matthews DM, Maclntyre CC, Little K, Clarke BF (1987) Comparison of intravenous glucagon and dextrose in treatment of severe hypoglycemia in an accident and emergency department. Diabetes Care 10:712–715
Cronenwett JL (1993a) Acute mesenteric ischaemia. In: Picazo J (ed) Glucagon in acute medicine. Kluwer Academic, Dordrecht, p 83
Cronenwett JL (1993b) Mesenteric ischemia. In: Picazo J (ed) Glucagon in acute medicine. Kluwer Academic, Dordrecht, p 131
Cronenwett JL, Ayad M, Kazmers A (1985) Effect of intravenous glucagon on the survival of rats after acute occlusive mesenteric ischemia. J Surg Res 38:446–452
Crump BJ, Holt DW, Vales JA (1982) Lack of response to intravenous calcium in severe verapamil poisoning. Lancet I:939–940
D’Almeida MS, Lautt WW (1989) The effect of glucagon on vasoconstriction and vascular escape from nerve and norepinephrine-induced constriction of the hepatic artery of the cat. Can J Physiol Pharmacol 67:1418
D’Almeida MS, Lautt WW (1991) Glucagon pharmacodynamics and modulation of sympathetic nerve and norepinephrine-induced constrictor responses in the superior mesenteric artery of the cat. J Pharmacol Exp Ther 259:118
Danford RO (1970) The effect of glucagon on renal hemodynamics and renal arteriography. Am J Roentgenol Radium Ther Nucl Med 108:665
Daniel O, Basu PK, Al-Samarrae HM (1974) Use of glucagon in the treatment of acute diverticulitis. Br Med J 3:720–722
Davies DM, MacIntyre A, Millar EJ, Bell SM, Mehra SK (1967) Need for glucagon in severe hypoglycemia induced by sulphonylurea drugs. Lancet 1:363–364
Demling RH, Manohar M, Will J (1978) The effect of glucagon on the pulmonary transvascular fluid filtration rate. Chest 74:196–199
Diamond G, Forrester J, Danzig R, Parmley WW, Swan HJC (1971) Acute myocardial infarction in man: comparative hemodynamic effects of norepinephrine and glucagon. Am J Cardiol 27:612–616
Diez-Jarilla JL, Gonzalez-Macias J, Laso-Guzman FJ, de Castro del Pozo S (1981) Beta-blockade in asthma (letter). Br Med J 283:309
Doman DB, Ginsberg AL (1981) Glucagon infusion therapy for biliary tree stones. Gastroenterology 80:1137
Doyon S, Roberts JR (1993) The use of glucagon in a case of calcium channel blocker overdose. Ann Emerg Med 22:1229–1233
Drucker MR, Pindyck F, Brown RS, Elwyn DH, Shoemaker WC (1974) The interaction of glucagon and glucose on cardiorespiratory variables in the critically ill patient. Surgery 75:487
Durr HK, Maroske D, Zelder O, Bode JC (1978) Glucagon therapy of acute pancreatitis — report of a double blind trial. Gut 19:175–179
Eddy JD, O’Brien ET, Singh SP (1969) Glucagon and haemodynamics of acute myocardial infarction. Br Med J 4:663
Edell SL (1980) Erythema multiforme secondary to intravenous glucagon. Am J Radiol 134:385
El-Naggar M, Collins VJ (1974) Spirometry following glucagon and isoproterenol in chronic obstructive pulmonary disease. Crit Care Med 2:82–85
Elrick H, Witten TA, Arai Y (1958) Glucagon treatment of insulin reactions. N Engl J Med 258:476
Farah A, Tuttle R (1960) Studies on the pharmacology of glucagon. J Pharmacol Exp Ther 129:49
Farah AE (1983) Glucagon and the circulation. Pharmacol Rev 35:181
Farivar M, Wands JR, Isselbacher KJ, Bucher NLR (1976) Effect of insulin and glucagon in fulminant murine hepatitis. N Engl J Med 295:1517–1519
Feher J, Cornides A, Romany A, Karteszi M, Szalay L, Gogl A, Picazo J (1987) A prospective multicenter trial of insulin and glucagon infusion therapy in acute alcoholic hepatitis. J Hepatol 5:224–231
Ferrucci JT, Long JA (1977) Radiologic treatment of esophageal food impaction using intravenous glucagon. Radiology 125:25
Ferrucci JT, Wittenberg J, Stone LB, Dreyfuss JR (1976) Hypotonic cholangiography wiht glucagon. Radiology 118:466
Freychet L, Rizkalla SW, Desplanque N, Basdevant A, Zirinis P, Tchobroutsky G, Slama G (1988) Effect of intranasal glucagon on blood glucose levels in healthy subjects and hypoglycaemic patients with insulin-dependent diabetes. Lancet I:1364–1366
Frishman W, Jacob H, Eisenberg E, Ribner H (1979) Clinical pharmacology of the new beta-adrenergic blocking drugs: part 8: self-poisoning with beta-adrenergic blocking agents: recognition and management. Am Heart J 98:798–811
Fugiwara K, Ogata I, Mishiro S, Ohta Y, Oka Y, Takatsuki K, Sato Y, Hayashi S (1988) Glucagon and insulin for the treatment of hepatic failure in dimethylnitrosamine intoxicated rats. Scand J Gastroenterol 23:567
Gagnon G, Regoli D, Rioux F (1980) Studies on the mechanism of action of glucagon in strips of rabbit renal artery. Br J Pharmacol 69:389
Gerich JE, Lorenzi M, Bier DM, Schneider V, Tsalikian E, Karam JH, Forshamm PH (1975) Prevention of human diabetic ketoacidosis by somatostatin. Evidence for an essential role of glucagon. N Engl J Med 292:985–989
Gilsanz V, Oteyza CP, Rebollar JL (1978) Glucagon vs anticholinergics in the treatment of acute pancreatitis: a double-blind controlled trial. Arch Intern Med 138:535–538
Glick G, Parmley WW, Wechsler AS, Sonnenblick EH (1968) Glucagon: its enhancement of cardiac performance in the cat and dog and persistence of its inotropic action despite beta-receptor blockade with propranolol. Circ Res 22:789
Grossi E, Broggini M, Quaranta M, Balestrino E (1986) Different pharmacologic approaches to the treatment of acute biliary colic. Curr Ther Res 40:876–882
Guillen J, Pappas G (1972) Improved cardiovascular effects of glucagon in dogs with endotoxin shock. Ann Surg 175:535
Gupta MM, Prasad K (1980) Studies of the effects of glucagon on ouabain-induced cardiac disorders using the PISA method. In: Tajuddin M, Das PK, Tariq M, Dhalla NS (eds) Advances in myocardiology, vol 1. University Press, Baltimore, p 313
Handal KA, Riordan W, Siese J (1980) The lower esophagus and glucagon. Ann Emerg Med 9:577
Harford FJ (1979) Use of glucagon in conjunction with end-to-end anastomosis (EEA) stapling device for low anterior anastomoses. Dis Colon Rectum 22:452
Harrison PM, Hughes RD, Forbes A, Portmann B, Alexander GJM, Williams R (1990) Failure of insulin and glucagon infusion to stimulate liver regeneration in fulminant hepatic failure. J Hepatol 10:1–5
Hvidberg A, Djurup R, Hilsted J (1994) Glucose recovery after intranasal glucagon during hypoglycemia in man. Eur J Clin Pharmacol 46:15
Imbruce R, Goldfedder A, Macguire W, Briscoe W, Nair S (1975) The effect of glucagon on airway resistance. J Clin Pharmacol 15:680–684
Jain KM, Rush BF Jr, Hastings OM, Ghosh A, Slotman G, Albousamra S (1978) Glucagon treatment of hemorrhagic shock: improved survival and metabolic parameters in a murine shock model. Adv Shock Res 1:149
Jolly SR, Kipnis JN, Lucchesi BR (1987) Cardiovascular depression by verapamil: reversal by glucagon and interactions with propranolol. Pharmacology 35:249–255
Jones RM, Fiddian-Green R, Knight PR (1980) Narcotic induced choledochoduodenal sphincter spasm reversed by glucagon. Anesth Analg 59:946–947
Jones RM, Detmer M, Hill AB, Bjoraker DG, Pandit U (1981) Incidence of choledochoduodenal sphincter spasm during fentanyl-supplemented anesthesia. Anesth Analg 60:638–640
Kahnoski RJ, Lingeman JE, Woods JR, Eckley R, Brooks-Brunn J, Coury TA (1987) Efficacy of glucagon in the relief of uretheral colic following treatment by extracoporeal shock wave lithotripsy: a randomized double-blind trial. J Urology 137:1124
Kalima TV, Lempinen M (1980) The effect of zinc-protamine-glucagon in acute pancreatitis. Ann Chir 69:293–295
Kaszar-Seibert DJ, Korn WT, Bindman DJ, Shortsleeve MJ (1990) Treatment of acute esophageal food impaction with a combination of glucagon, effervescent agent, and water. Am J Radiol 154:533–534
Katz AI, Lindheimer MD (1977) Actions of hormones on the kidney. Annu Rev Physiol 39:97
Kazmers A, Whitehouse WM Jr, Lindenauer SM, Stanley JC (1981) Dissociation of glucagon’s central and peripheral hemodynamic effects: mechanisms of reduction and redistribution of canine hindlimb blood flow. J Surg Res 30:384
Kazmers A, Zwolak R, Appelman HD, Whitehouse WM Jr, Wu SC, Zelenock GB, Cronenwett JL, Lindenauer SM, Stanley JC (1984) Pharmacologic interventions in acute mesenteric ischemia: improved survival with intravenous glucagon, methylprednisolone, and prostacyclin. J Vasc Surg 1:472–481
Kirschenbaum MA, Zawada ET (1980) The role of prostaglandins in glucagon-induced natriuresis. Clin Sci 58:393
Kline JA, Leonova E, Raymond RM (1995) Beneficial myocardial metabolic effects of insulin during verapamil toxicity in the anesthetized canine. Crit Care Med 23:1251–1263
Knight MJ, Condon JR, Day JL (1972) Possible role of glucagon in pathogenesis of acute pancreatitis. Lancet 1:1097–1099
Kock NG, Tibblin S, Schenk WG Jr (1970) Hemodynamic responses to glucagon: an experimental study of central, visceral and peripheral effects. Ann Surg 171:373
Kock NG, Tibblin S, Schenk WG Jr (1971) Modification by glucagon of the splanchnic vascular responses to activation of the sympathicoadrenal system. J Surg Res 11:12
Kones RJ, Phillips JH (1971) Glucagon: present status in cardiovascular disease. Clin Pharmacol Ther 12:427
Kosinski EJ, Malindzak GS (1973) Glucagon and isoproterenol in reversing propranolol toxicity. Arch Intern Med 132:840–843
Lawrence AM (1967) Glucagon provocative test for pheochromocytoma. Ann Intern Med 66:1091
Lebovics E, Rosenthal WS (1991) Glucagon precipitation of carcinoid flush. Gastrointest Endosc 37:212–213
Li SJ, Nussbaum MS, McFadden DW, Gapen CL, Dayal R, Fischer JE (1988) Addition of glucagon to total parenteral nutrition prevents hepatic steatosis in rats. Surgery 104:350–357
Lickley HL, Kemmer FW, Doi K, Vranic M (1983) Glucagon suppression improves glucoregulation in moderate but not chronic severe diabetes. Am J Physiol 245:E424
Lilly MP, Harward TRS, Flinn WR, Blackburn DR, Astleford PM, Yao JST (1989) Duplex ultrasound measurement of changes in mesenteric flow velocity with pharmacologic and physiologic alteration of intestinal blood flow in man. J Vasc Surg 9:10–25
Lindberg B, Darle N (1977) The effect of glucagon and blood transfusion on hepatic circulation and oxygen consumption in hemorrhagic shock. J Surg Res 23:257–263
Linden CH, Aghababian RV (1985) Further uses of glucagon. Crit Care Med 13:248
Lockey SD, Reed CE, Ouellette JJ (1969) Bronchodilating effect of glucagon in asthma. J Allergy 43:177–178
Love JN, Tandy TK (1993) Beta-adrenergic anatgonist toxicity: a survey of glucagon availability. Ann Emerg Med 22:267
Love JN, Leasure JA, Mundt DJ, Janz TG (1992) A comparison of amrinone and glucagon therapy for cardiovascular depression associated with propranolol toxicity in a canine model. Clin Toxicol 30:399–412
Love JN, Leasure JA, Mundt DJ (1993) A comparison of combined amrinone and glucagon therapy to glucagon alone for cardiovascular depression associated with propranolol toxicity in a canine model. Am J Emerg Med 11:360
Lowman RM, Belleza NA, Goetsch JB, Finkelstein HI, Berneike RR, Rosenfield AT (1977) Glucagon (letter). J Urol 118:128
Lucchesi BR (1968) Cardiac actions of glucagon. Circ Res 22:777
Lvoff R, Wilcken DE (1972) Glucagon in heart failure and in cardiogenic shock. Experience in 50 patients. Circulation 45:534–542
MacCuish AC, Munro JF, Duncan LJ (1970) Treatment of hypoglycemic coma with glucagon, intravenous dextrose, and mannitol infusion in a hundred diabetics. Lancet 11:946
MacLeod KM, Rodgers RL, McNeill JH (1981) Characterization of glucagon-induced changes in rate, contractility and cyclic AMP levels in isolated cardiac preparations of the rat and guinea pig. J Pharmacol Exp Ther 217:798
Madan BR (1971) Effect of glucagon on ventricular arrhythmias after coronary artery occlusion and on ventricular automaticity in the dog. Br J Pharmacol 43:279
Madden JJ Jr, Ludewig RM, Wagensteen SL (1971) Effects of glucagon on the splanchnic and the systemic circulation. Am J Surg 122:85
Malcolm D, Zaloga G, Chernow B, Holaday J (1986) Glucagon is an antagonist of morphine bradycardia and antinociception. Life Sci 39:399
Manabe T, Steer ML (1979) Experimental acute pancreatitis in mice. Protective effects of glucagon. Gastroenterology 76:529–534
Marks HW, Lousteau RJ (1979) Glucagon and esophageal meat impaction. Arch Otolaryngol 105:367
Marri G, Cozzolono G, Palumbo R (1968) Glucagon in sulphonylurea hypoglycemia? Lancet I:303
Marsiglia JC, Moreyra AE, Lardani H, Cingolani HE (1970) Glucagon: its effect upon myocardial oxygen consumption. Eur J Pharmacol 12:265
Medical Research Council Multicentre Trial (1980) Morbidity of acute pancreatitis — the effect of aprotinin and glucagon. Gut 21:334–339
Mery PF, Brechler V, Pavoine C, Pecker F, Fischmeister R (1990) Glucagon stimulates the cardiac Cat current by activation of adenylyl cyclase and inhibition of phosphodiesterase. Nature 345:158
Minkov N, Shumleva V, Pironkov A, Gotsev G, Voinikova IN, Nicolov N (1988) A new method for the management of ureteral colic after extracorporeal shock wave lithotripsy. Int Urol Nephrol 20:251–255
Morgan TR (1993) Treatment of alcoholic hepatitis. Semin Liver Dis 13:384–394
Morishima MS, Ghaed N (1978) Glucagon and diuresis in the treatment of ureteral calculi. Radiology 129:807–809
Moura AM, Simpkins H (1975) Cyclic AMP levels in cultured myocardial cells under the influence of chronotropic and inotropic agents. J Mol Cell Cardiol 7:71
Muhlhauser I, Koch J, Berger M (1985a) Pharmacokinetics and bioavailability of injected glucagon: differences between intramuscular, subcutaneous, and intravenous administration. Diabetes Care 8:39–42
Muhlhauser I, Berger M, Sonnenberg G, Koch J, Jorgens V, Schernthaner G, Scholz V, Padagogin D (1985b) Incidence and management of severe hypoglycemia in 434 adults with insulin-dependent diabetes mellitus. Diabetes Care 8:268–273
Muraro GB, Ruin G, Giusti G, Mazzarino A, Torri T, Lattanzi P (1982) Glucagon and hyperdiuresis in the treatment of ureteral calculi. Min Urol 34:111–115
Murtaugh JG, Binnion PF, Lal S, Hutchinson KJ, Fletcher E (1970) Haemodynamic effects of glucagon. Br Heart J 32:307–310
Nayler WG, McInnes I, Chipperfield D, Carson V, Daile P (1970) The effect of glucagon on calcium exchangeability, coronary blood flow, myocardial function and high energy phosphate stores. J Pharmacol Exp Ther 171:265
Nepper-Rasmussen J, Storgaard Pedersen O, Anderson A, Dalssgaard J (1984) Glucagon and ureteral colic. Urol Res 12:23–24
Newman BR, Schultz LK (1981) Epinephrine resistant anaphylaxis in a patient taking propranolol hydrochloride. Ann Allergy 47:35–36
Niemann JT, Haynes KS, Garner D, Jagels G, Rennie CJ (1987) Postcountershock pulseless rhythms: hemodynamic effects of glucagon in a canine model. Crit Care Med 15:554–558
Nord HJ, Fontaines AL, Williams JF (1970) Treatment of congestive heart failure with glucagon. Ann Intern Med 72:649–653
Oka H, Fujiwara K, Okita K, Ishii H, Sakuma A (1989) A multi-centre double-blind controlled trial of glucagon and insulin therapy for severe acute hepatitis. Gastroenterol Jpn 24:332–336
Okamura T, Miyazaki M, Toda N (1986) Responses of isolated dog blood vessels to glucagon. Eur J Pharmacol 125:395
Oshima A, Kitajima M (1993) Intestinal strangulation. In: Picazo J (ed) Glucagon in acute medicine. Kluwer Academic, Dordrecht, p 107
Oshima A, Kitajima M, Sakai N, Ando N (1990) Does glucagon improve the viability of ischemic intestine? J Surg Res 49:524–533
O’Mahony D, O’Leary P, Molloy MG (1990) Severe oxprenolol poisoning: the importance of glucagon infusion. Hum Exp Toxicol 9:101–103
Papp M, Ribet A, Fodor I, Nemeth PE, Feher S, Horvath JE, Folly G (1975) Glucagon treatment of experimental acute pancreatitis. Acta Med Acad Sci Hung 32:105–116
Parmley WW, Glick G, Sonnenblick EH (1968) Cardiovascular effects of glucagon in man. N Engl J Med 279:12–17
Parmley WW, Matloff JM, Sonnenblick EH (1969) Hemodynamic effects of glucagon in patients following prosthetic valve replacement. Circulation 39:1163
Patrick AW, Collier A, Hepburn DA, Steedman DJ, Clarke BF, Robertson C (1990) Comparison of intramuscular glucagon and intravenous dextrose in the treatment of hypoglycemic coma in an accident and emergency department. Arch Emerg Med 7:73–77
Paul F (1979) The role of glucagon in the treatment of biliary tract pathology. In: Picazo J (ed) Glucagon in gastroenterology. MTP Press, Lancaster, p 107
Pavoine C, Brechler V, Kervran A, Blache P, Le-Nguyen D, Laurent S, Bataille D, Pecker F (1991) Miniglucagon [glucagon-(19–29)] is a component of the positive inotropic effect of glucagon. Am J Physiol 260:C993
Peterson A, Lucchesi B, Kirsh MM (1978) The effect of glucagon in animals on chronic propranolol therapy. Ann Thorac Surg 25:340
Peterson CD, Leeder JS, Sterner S (1984) Glucagon therapy for ß-blocker overdose. Drug Intell Clin Pharm 18:394
Pillari G, Bank S, Katzka I, Fulco JD (1979) Meat bolus impaction and the lower esophagus associated with paraesophageal hernia. Successful noninvasive treatment with intravenous glucagon. Am J Gastroenterol 71:287
Prasad K (1975) Electrophysiologic effects of glucagon on human cardiac muscle. Clin Pharmacol Ther 18:22
Prasad K (1977) Use of glucagon in the treatment of quinidine toxicity in the heart. Cardiovasc Res 11:53
Prasad K, DeSousa HH (1972) Glucagon in the treatment of ouabain-induced cardiac arrhythmias in dogs. Cardiovasc Res 6:333
Prasad K, Weckworth P (1978) Glucagon in procainamide-induced cardiac toxicity. Toxicol Appl Pharmacol 46:517
Prielipp RC, Hill T, Washburn D, Zaloga GP (1989) Circulating calcium modulates adrenaline-induced cyclic adenosine monophosphate production. Cardiovasc Res 23:838
Pullman TN, Lavender AR, Aho I (1967) Direct effects of glucagon on renal hemodynamics and excretion of inorganic ions. Metabolism 16:358
Puri PS, Bing RJ (1979) Effects of glucagon on myocardial contractility and hemodynamics in acute experimental myocardial infarction: basis for its possible use in cardiogenic shock. Am Heart J 78:660–668
Quezado Z, Lippmann M, Wertheimer J (1991) Severe cardiac, respiratory, and meta- bolic complications of massive verapamil overdose. Crit Care Med 19:436–438
Qvigstad T, Larsen S, Myren J (1979) Comparison of glucagon, atropine, and placebo as premedication for endoscopy of the upper gastrointestinal tract. Scand J Gastroenterol 14:231
Radvan G, Kanel G, Redeker A (1982) Insulin and glucagon infusion in acute alcoholic hepatitis. Gastroenterology 82:1154
Ratcliff KM (1991) Esophageal foreign bodies. Am Fam Physician 44:824–831
Regan TJ, Lehan PH, Henneman DH, Behar A, Hellems HK (1964) Myocardial, metabolic and contractile response to glucagon and epinephrine. J Lab Clin Med 63:638
Richardson PD, Withrington PG (1976) The inhibition by glucagon of the vasoconstrictor actions of noradrenaline, angiotensin and vasopressin on the hepatic arterial vascular bed of the dog. Br J Pharmacol 57:93
Roark KM, Suzuki NT (1987) Glucagon use in mesenteric ischemia. Drug Intell Clin Pharm 21:660–661
Robbins MI, Shortsleeve MJ (1994) Treatment of acute esophageal food impaction with glucagon, an effervescent agent, and water. Am J Radiol 162:325–328
Ros SP (1993) Genitourinary emergencies and glucagon. In: Picazo J (ed) Glucagon in acute medicine. Kluwer Academic, Dordrecht, p 37
Rosenfalck AM, Bendtson I, Jorgensen S, Binder C (1992) Nasal glucagon in the treatment of hypoglycemia in type 1 (insulin-dependent) diabetic patients. Diabetes Res Clin Prac 17:43–50
Ross EM, Gilman AG (1980) Biochemical properties of hormone-sensitive adenylate cyclase. Annu Rev Biochem 49:533
Ruddy JM, Seymour JL, Anderson NG (1972) Management of tricyclic antidepressant ingestion in children with special reference to the use of glucagon. Med J Aust 1:630–633
Sabatier J, Pouyet T, Shelvey G, Cavero I (1991) Antagonistic effects of epinephrine, glucagon and methylatropine but not calcium chloride against atrio-ventricular conduction disturbances produced by high doses of diltiazem, in conscious dogs. Fundam Clin Pharmacol 5:93–106
Sardella GL, Bech FR, Cronenwett JL (1990) Hemodynamic effects of glucagon after acute mesenteric ischemia in rats. J Surg Res 49:354–360
Sato S, Tsuji MH, Okuba N, Naito H (1994) Milrinone versus glucagon: comparative hemodynamic effects in canine propranolol poisoning. Clin Toxicol 32:277
Schorr RT, Rogers SN (1987) Intraoperative cardiovascular crisis caused by glucagon. Arch Surg 122:833
Scian LF, Westermann CD, Verdesca AS, Hilton JG (1960) Adrenocortical and medullary effects of glucagon. Am J Physiol 199:867
Sener EK, Gabe S, Henry JA (1995) Response to glucagon in imipramine overdose. J Toxicol Clin Toxicol 33:51–53
Sherman MS, Lazar EJ, Eichacker P (1988) A bronchodilator action of glucagon. J Allergy Clin Immunol 81:908–911
Siegel JH, Levine MJ, McConn R, DelGuercio LR (1970) The effect of glucagon infusion on cardiovascular function in the critically ill. Surg Gynecol Obstet 131:505
Simaan J, Fawaz G (1976) The cardiodynamic and metabolic effects of glucagon. Naunyn Schmiedebergs Arch Pharmacol 294:277
Singh J, Bala S, Kaur AH, Garg KN (1980) Effect of glucagon on arrhythmias induced by coronary artery occlusion and ouabain in dogs. Indian J Physiol 24:329
Slama G, Reach G, Cahane M, Quetin C, Villanove-Robin F (1992) Intranasal glucagon in the treatment of hypoglycemic attacks in children: experience at a summer camp (letter). Diabetologia 35:398
Smitherman TC, Osborn RC Jr, Atkins JM (1978) Cardiac dose response relationship for intravenously infused glucagon in normal intact dogs and men. Am Heart J 96:363
Steel JM, Allwinkle J, Moffat R, Carrington DJ (1992) Use of lucozade and glucagons by ambulance staff for treating hypoglycaemia. Br Med J 304:1283–1284
Steinberg WM, Schlesselman SE (1987) Treatment of acute pancreatitis: comparison of animal and human studies. Gastroenterology 93:1420–1427
Stenninger E, Aman J (1993) Intranasal glucagon relieves hypoglycemia in children with type 1 (insulin dependent) diabetes mellitus. Diabetologia 36:931–935
Stewart JW, Myerburg RJ, Hoffman BF (1969) The effect of glucagon on quinidine-induced changes in Purkinje fibers. Circulation 40:196
Stone CK, May WA, Carroll R (1995) Treatment of verapamil overdose with glucagon in dogs. Ann Emerg Med 25:369–374
Stower MJ, Foster GE, Hardcastle JD (1982) A trial of glucagon in the treatment of painful biliary tract disease. Br J Surg 69:591–592
Tai YT, Lo CW, Chow WH, Cheng CH (1990) Successful resuscitation and survival following massive overdose of metoprolol. Br J Clin Pract 44:746
Talesnik J, Tsoporis J (1984) Enhancement by glutathione of the inotropic actions of catecholamines and glucagon. J Mol Cell Cardiol 16:573
Taylor JR, Sherratt HS, Davies DM (1978) Intramuscular or intravenous glucagon for sulphonylurea hypoglycemia? Eur J Clin Pharmacol 14:125–127
Thomas S, Stone K, May WA (1995) Exacerbation of verapamil induced hyperglycemia with glucagon. Am J Emerg Med 13:27
Tibblin S, Kock NG, Schenk WG Jr (1971) Response of mesenteric blood flow to glucagon. Influence of pharmacological stimulation and blockade of adrenergic receptors. Arch Surg 102:65
Timmus GC, Lin R, Ramos RG, Gordon S (1973) Prolonged glucagon infusion in cardiac failure. J Am Med Assoc 223:293–296
Trinchet JC, Balkau B, Poupon RE, Heintzmann F, Callard P, Gotheil C, Grange JD, Vetter D, Pauwels A, Labadie H (1992) Treatment of severe alcoholic hepatitis by infusion of insulin and glucagon: a multicenter sequential trial. Hepatology 15:7681
Ueda J, Nakanishi H, Miyazaki M, Abe Y (1977) Effects of glucagon on the renal hemodynamics of dogs. Eur J Pharmacol 41:209
Vadhera RB (1992) Propranolol overdose (letter). Anesthesia 47:279
Vander-Ark CR, Reynolds EW (1979) Clinical evaluation of glucagon by continuous infusion in the treatment of low cardiac output states. Am Heart J 79:481–487
VanderWall DA, Stowe NT, Spangenberg R, Hook JB (1970) Effect of glucagon in hemorrhagic shock. J Surg Oncol 2:177
Vukmir RB, Paris PM, Yealy DM (1991) Glucagon: prehospital therapy for hypoglycemia. Ann Emerg Med 20:375–379
Walter FG, Frye G, Mullen JT, Ekins BR, Khasigian PA (1993) Amelioration of nifedipine poisoning associated with glucagon therapy. Ann Emerg Med 22:1234–1237
Warner WA, Begley L, Penman RW (1971) Effect of glucagon on pulmonary airflow resistance in dogs. Fed Proc 30:55S
Waterworth MW, Barbezat GO, Hickman R, Terblanche J (1976) A controlled trial of glucagon in experimental pancreatitis. Br J Surg 63:617–620
Weigelt JA, Gewertz BL, Aurbakken CM, Snyder WH (1982) Pharmacologic alterations in pulmonary artery pressure in the adult respiratory distress syndrome. J Surg Res 32:243
Weingand KW, Fettman MJ, Phillips RW, Hand MS (1986) Metabolic effects of glucagon in endotoxemic minipigs. Circ Shock 18:289–300
Weinstein RS (1984) Recognition and management of poisoning with beta-adrenergic blocking agents. Ann Emerg Med 13:1123
Whitsitt LS, Lucchesi BR (1968) Effects of beta-receptor blockade and glucagon on the atrioventricular transmission system in the dog. Circ Res 23:585
Wilcken DE, Lvoff R (1970) Glucagon in resistant heart-failure and cardiogenic shock. Lancet 1:1315
Wilson JE, Fontanarosa PB (1993) Glucagon for the treatment of respiratory emergencies. In: Picazo J (ed) Glucagon in acute medicine. Kluwer, Dordrecht, p 27
Wilson JE, Nelson RN (1990) Glucagon as a therapeutic agent in the treatment of asthma. J Emerg Med 8:127–130
Wolf LR, Spadafora MP, Otten EJ (1993) Use of amrinone and glucagon in a case of calcium channel blocker overdose. Ann Emerg Med 22:1225–1228
Woolf GM, Redeker AG (1991) Treatment of fulminant hepatic failure with insulin and glucagon. A randomized control trial. Dig Dis Sci 36:92–96
Wright CD, Kazmers A, Whitehouse WM Jr, Stanley JC (1985) Comparative hemodynamic effects of selective superior mesenteric arterial and peripheral intravenous glucagon infusions. J Surg Res 39:230
Xenophontos XP, Watson PA, Chua BH, Haneda T, Morgan HE (1989) Increased cyclic AMP content accelerates protein synthesis in rat heart. Circ Res 65:647
Zaloga GP, Malcolm D, Holaday J et al (1985) Glucagon reverses the hypotension and bradycardia of verapamil overdose in rats (abstract). Crit Care Med 13:273
Zaloga GP, Delacey W, Holmboe E, Chernow B (1986) Glucagon reversal of hypotension in a case of anaphylactoid shock. Ann Intern Med 105:65
Zaloga GP, Malcolm DS, Holaday JW, Chernow B (1988) Glucagon. In: Chernow B (ed) The pharmacologic approach to the critically ill patient, 2nd edn. Williams and Wilkins, Baltimore, p 659
Zaritsky AL, Horowitz M, Chernow B (1988) Glucagon antagonism of calcium channel blocker-induced myocardial dysfunction. Crit Care Med 16:246
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Johnson, M.M., Zaloga, G.P. (1996). The Place of Glucagon in Emergency Medicine. In: Lefèbvre, P.J. (eds) Glucagon III. Handbook of Experimental Pharmacology, vol 123. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61150-6_11
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