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The various roles of invariant chain in the act of antigen Presentation

  • Conference paper
Book cover Molecular Dynamics of Biomembranes

Part of the book series: NATO ASI Series ((ASIH,volume 96))

Abstract

Foreign antigen are internalized by antigen presenting cells and processed to peptides presented in the context of major histocompatibility complex (MHC) class II molecules to CD4+ T cells at the plasma membrane. Hence, class II molecules have to be sorted to endosomal compartments where they can meet and bind the antigenic peptides. The class II associated invariant chain contains sorting signals required for efficient class II accumulation in endosomes. Invariant chain also has several other features contributing to the immune system’s specific combat of invaders.

* The two first authors, T.W.N and A.S. have contributed equally to this paper.

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  1. Div. Molecular Cell Biology, Department of Biology, University of Oslo, 0316, Oslo, Norway

    Tommy W. Nordeng, Anne Simonsen & Oddmund Bakke

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  1. Centre for Biomembranes and Lipid Enzymology, Institute of Biomembranes Utrecht University, Padualaan 8, 3584, CH Utrecht, The Netherlands

    Jos A. F. Op den Kamp

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Nordeng, T.W., Simonsen, A., Bakke, O. (1996). The various roles of invariant chain in the act of antigen Presentation. In: Op den Kamp, J.A.F. (eds) Molecular Dynamics of Biomembranes. NATO ASI Series, vol 96. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61126-1_3

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