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Multiple Myeloma Associated with Amyloidosis

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Gene Technology

Part of the book series: NATO ASI Series ((ASIH,volume 94))

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Abstract

Survival data on patients with multiple myeloma (MM) associated with amyloidosis AL (AL) are variable: median survival varies from 5 months (Kyle, 1983) to 29 months (Pruzanski, Katz, 1976). According to Kyle et al. (1976) systemic AL with typical symptoms of organ and system damage is not often revealed among patients with apparent myeloma. Fielder and Durie (1980) suggest that MM associated with AL is more frequent than reported. The pathogenetic relationship between AL and plasma cell malignancy has not been elucidated. Retrospective analysis and prospective observation of patients with different MM activity and AL were carried out in order to determine the prognostic significance of AL for the disease course and survival. Progression of malignancy is determined by the biology of malignant cells, host organism and tumor mass interactions (Ioshua, 1988). Hence, we studied some functional characteristics of peripheral blood mononuclear cells (PBM) in MM patients with or without AL.

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Author information

Authors and Affiliations

  1. Internal Medicine Department Nl, Pavlov Medical University, Leo Tolstoy str, 197089, St.Petersburg, Russia

    N. Podoltsev

  2. Bone Marrow Transplantation Department, St.Petersburg Cente for Advanced Medical Technologes, pr. Dinamo 3, 197042, St.Petersburg, Russia

    E. Podoltseva

  3. Bone Marrow Transplantation Department, Petrov Oncology Institute, Leningradskaya str. 68, 188646, Pesochny 2, Russia

    E. Morozova

Authors
  1. N. Podoltsev
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  2. E. Podoltseva
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  3. E. Morozova
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Editor information

Editors and Affiliations

  1. Universitätskrankenhaus Eppendorf, Martinistraße 52, D-20246, Hamburg, Germany

    Axel R. Zander

  2. Heinrich-Pette-lnstitut für Experimentelle Virologie und Immunologie, Universität Hamburg, Martinistraße 52, D-20246, Hamburg, Germany

    Wolfram Ostertag

  3. City Center for Advanced Medical Technologies, Bone Marrow Transplantation Center, Pr. Dynamo 3, 197042, St.Petersburg, Russia

    Boris V. Afanasiev

  4. Laboratory for Gene Structure Expression, Medical Research Council Institute, The Ridgeway, Mill Hill, London, NW71AA, UK

    Frank Grosveld

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© 1996 Springer-Verlag Berlin Heidelberg

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Podoltsev, N., Podoltseva, E., Morozova, E. (1996). Multiple Myeloma Associated with Amyloidosis. In: Zander, A.R., Ostertag, W., Afanasiev, B.V., Grosveld, F. (eds) Gene Technology. NATO ASI Series, vol 94. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61122-3_35

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  • DOI: https://doi.org/10.1007/978-3-642-61122-3_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64704-8

  • Online ISBN: 978-3-642-61122-3

  • eBook Packages: Springer Book Archive

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