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Alterations in Cell Cycle Control During Tumor Progression: Effects on Apoptosis and the Response to Therapeutic Agents

  • Chapter
Attempts to Understand Metastasis Formation II

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 213/2))

Abstract

It has long been apparent that alterations in the control of the cell cycle accompany the development of tumorigenicity. The mere observation that cell growth continues in tumors whereas normal cells for the most part cease dividing and retain a diploid amount of DNA suggests that the controls regulating the normal cell cycle have failed to function in the tumor cell. In recent years the biochemical mechanisms underlying the transitions through the cell cycle have begun to be identified, and some of the gene products that are mutated in cancer cells have been shown to interact directly with these genes in control of the cell cycle. These mutated genes, as well as the cell cycle regulators, have been shown to affect whether cells undergo programmed cell death and to influence how cells respond to DNA-damaging agents that are frequently used therapeutically. Thus the genetic changes in the cell that affect cell cycle progression also have a bearing on the therapeutic outcome. While the description of the changes affecting the G0 to G1 to S phase transition is currently better understand as regards malignancy, the G2/M to phase transition also has important implications for therapy.

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Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, University of Pennsylvania, 19104-6082, Philadelphia, PA, USA

    R. J. Muschel

  2. Department of Radiation Oncology, University of Pennsylvania, 19104-6082, Philadelphia, PA, USA

    W. G. McKenna

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Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Ursula Günthert Ph.D., PD

  2. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Straße 10, D-13122, Berlin, Germany

    Walter Birchmeier Ph.D.

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Muschel, R.J., McKenna, W.G. (1996). Alterations in Cell Cycle Control During Tumor Progression: Effects on Apoptosis and the Response to Therapeutic Agents. In: Günthert, U., Birchmeier, W. (eds) Attempts to Understand Metastasis Formation II. Current Topics in Microbiology and Immunology, vol 213/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61109-4_9

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  • DOI: https://doi.org/10.1007/978-3-642-61109-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64698-0

  • Online ISBN: 978-3-642-61109-4

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