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Attempts to Understand Metastasis Formation II pp 137–169Cite as

Regulation of Autocrine Motility Factor Receptor Expression in Tumor Cell Locomotion and Metastasis

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Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 213/2))

Abstract

Active locomotion by invading tumor cells is thought to be a prerequisite step in the establishment of secondary neoplasms. Successful metastasis requires the invasion of surrounding normal tissue and crossing of vascular and/or lymphatic boundaries (Nicolson 1988; Fidler 1990) and it has been suggested that motility of individual cells or groups of cells at the leading edge of a tumor protrusion might be responsible for such invasive movement (Strauli and Weiss 1977). Analysis of previously characterized high- and low-metastatic variant melanoma subpopulations has demonstrated that low-metastatic cells are largely immobile, while their high-metastatic counterparts exhibit profoundly greater locomotory activity (Raz and Geiger 1982; Volk et al. 1984; Geiger et al. 1985; Zvibel and Raz 1985; Raz and Ben-Ze’ev 1987). Similar findings were obtained using the Lewis lung carcinoma (Young et al. 1985) and a rat mammary adenocarcinoma model (Badenoch-Jones and Ramshaw 1984), while more recent work in the Dunning R-3327 rat prostatic adenocarcinoma model has further corroborated the relationship between motility and metastatic potential (Mohler et al. 1987, 1988; Partin et al. 1989).

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Authors and Affiliations

  1. Tumor Progression and Metastasis, Karmanos Cancer Institute, 48201, Detroit, MI, USA

    A. Raz

  2. Departments of Pathology and Radiation Oncology, Wayne State University School of Medicine, 48202, Detroit, MI, USA

    A. Raz

  3. Departments of immunology and Vascular Biology, Scripps Clinic and Research Foundation, 92037-1092, LA Jolla, CA, USA

    S. Silletti

Authors
  1. S. Silletti
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  2. A. Raz
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Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Ursula Günthert Ph.D., PD

  2. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Straße 10, D-13122, Berlin, Germany

    Walter Birchmeier Ph.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Silletti, S., Raz, A. (1996). Regulation of Autocrine Motility Factor Receptor Expression in Tumor Cell Locomotion and Metastasis. In: Günthert, U., Birchmeier, W. (eds) Attempts to Understand Metastasis Formation II. Current Topics in Microbiology and Immunology, vol 213/2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61109-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-61109-4_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64698-0

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