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Regulation of Autocrine Motility Factor Receptor Expression in Tumor Cell Locomotion and Metastasis

  • S. Silletti
  • A. Raz
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 213/2)

Abstract

Active locomotion by invading tumor cells is thought to be a prerequisite step in the establishment of secondary neoplasms. Successful metastasis requires the invasion of surrounding normal tissue and crossing of vascular and/or lymphatic boundaries (Nicolson 1988; Fidler 1990) and it has been suggested that motility of individual cells or groups of cells at the leading edge of a tumor protrusion might be responsible for such invasive movement (Strauli and Weiss 1977). Analysis of previously characterized high- and low-metastatic variant melanoma subpopulations has demonstrated that low-metastatic cells are largely immobile, while their high-metastatic counterparts exhibit profoundly greater locomotory activity (Raz and Geiger 1982; Volk et al. 1984; Geiger et al. 1985; Zvibel and Raz 1985; Raz and Ben-Zeev 1987). Similar findings were obtained using the Lewis lung carcinoma (Young et al. 1985) and a rat mammary adenocarcinoma model (Badenoch-Jones and Ramshaw 1984), while more recent work in the Dunning R-3327 rat prostatic adenocarcinoma model has further corroborated the relationship between motility and metastatic potential (Mohler et al. 1987, 1988; Partin et al. 1989).

Keywords

Melanoma Cell Pertussis Toxin Metastatic Melanoma Cell Gp78 Expression Autocrine Motility Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • S. Silletti
    • 3
  • A. Raz
    • 1
    • 2
  1. 1.Tumor Progression and MetastasisKarmanos Cancer InstituteDetroitUSA
  2. 2.Departments of Pathology and Radiation OncologyWayne State University School of MedicineDetroitUSA
  3. 3.Departments of immunology and Vascular BiologyScripps Clinic and Research FoundationLA JollaUSA

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