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Brain Metastasis: Role of Trophic, Autocrine, and Paracrine Factors in Tumor Invasion and Colonization of the Central Nervous System

  • G. L. Nicolson
  • D. G. Menter
  • J. L. Herrmann
  • Z. Yun
  • P. Cavanaugh
  • D. Marchetti
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 213/2)

Abstract

The brain is a unique target for tumor invasion and metastasis formation (Steck and Nicolson 1993; Nicolson 1993a; Menter et al. 1995a; Nicolson et al. 1994b. The central nervous system (CNS) is confined by the skull, and the brain is highly sensitive to the slightest change in the local microenvironment. The brain is also surrounded by a formidable blood-brain barrier (BBB), which does not allow penetration of most cell types. Because the brain lacks lymphatic drainage, cerebral edema is a major complication resulting from tumors in the CNS. When tumors form in the brain, either from endogenous brain cells or from metastases invading the BBB, they are very difficult to successfully treat. Therapy of brain tumors and metastases are often only palliative and are often accompanied by additional complications. A relatively small tumor in the brain cavity can cause severe symptoms, including impaired cognition, headaches, seizures, and eventually paralysis.

Keywords

Melanoma Cell Brain Metastasis Nerve Growth Factor Paracrine Factor Neurotrophin Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aaronson SA (1991) Growth factors and cancer. Science 254: 1146–1153PubMedGoogle Scholar
  2. Albino AP, Davis BM, Nanus DM (1991) Induction of growth factor RNA expression in human malignant melanoma: markers of transformation. Cancer Res 51: 4815–4820PubMedGoogle Scholar
  3. Alvarez JA, Baird A, Tatum A, Daucher J, Chorsky R, Gonzalez AM, Stopa EG (1992) Localization of basic fibroblast growth factor and vascular endothelial growth factor in human glial neoplasms. Mod Pathol 5: 303–307PubMedGoogle Scholar
  4. Avruch J, Zhang X, Kyriakis JM (1994) Raf meets Ras: completing the signal transduction pathway. Trends Biochem Sci 19: 279–283PubMedGoogle Scholar
  5. Banks WA, Kastin AJ (1992) Bidirectional passage of peptides across the blood brain barrier. Prog Brain Res 91: 139–148PubMedGoogle Scholar
  6. Barbacid M (1993) Nerve growth factor: a tale of two receptors. Oncogene 8: 2033–2042PubMedGoogle Scholar
  7. Barker PA, Shooter EM (1994) Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells. Neuron 13: 203–215PubMedGoogle Scholar
  8. Barrett GL, Bartlett PF (1994) The p75 nerve growth factor receptor mediates survival or death depending on stage of sensory neuron development. Proc Natl Acad Sci USA 91: 6501–6505PubMedGoogle Scholar
  9. Batistatou A, Volonte C, Greene LA (1992) Nerve growth factor employs multiple pathways to induce primary response genes in PC12 cells. Mol Biol Cell 3: 363–371PubMedGoogle Scholar
  10. Bennett DC, Holmes A, Devlin L, Hart IR (1994) Experimental metastasis and differentiation of murine melanoma cells: actions and interactions of factors affecting different intracellular signaling pathways. Clin Exp Metastasis 12: 385–397PubMedGoogle Scholar
  11. Berg MM, Sternberg DW, Hempstead BL, Chao MV (1991) The low-affinity p75 nerve growth factor (NGF) receptor mediates NGF-induced tyrosine phosphorylation. Proc Natl Acd Sci USA 88: 7106–7110Google Scholar
  12. Beutler B, van Huffel C (1994) Unraveling function in the TNF ligand and receptor families. Science 264: 667–668PubMedGoogle Scholar
  13. Birren SJ, Lo L, Anderson DJ (1993) Sympathetic neuroblasts undergo a developmental switch in trophic dependence. Development 119: 597–610PubMedGoogle Scholar
  14. Borrello MG, Pelicci G, Arighi E, De Philippis L, Greco A, Bongarzone I, Rizzetti M, Pelicci PG, Pierotti MA (1994) The oncogenic versions of the Ret and Trk tyrosine kinases bind She and Grb2 adaptor proteins. Oncogene 9: 1661–1668PubMedGoogle Scholar
  15. Bradshaw RA, Blundell TL, Lapatto R, McDonald NQ, Murray RJ (1993) Nerve growth factor revisited. Trends Biochem Sci 18: 48–52PubMedGoogle Scholar
  16. Bachman VL, Davies AM (1993) Different neurotrophins are expressed and act in a developmental sequence to promote the survival of embryonic sensory neurons. Development 118: 989–1001Google Scholar
  17. Buxser S, Puma P, Johnson GL (1985) Properties of the nerve growth factor receptor. Relationship between receptor structure and affinity. J Biol Chem 260: 1917–1926PubMedGoogle Scholar
  18. Cavanaugh PG, Nicolson GL (1989) Purification and some properties of lung-derived growth factor that differentially stimulates the growth of tumor cells metastatic to the lung. Cancer Res 89: 3928–3933Google Scholar
  19. Cavanaugh PG, Nicolson GL (1991) Lung-derived growth for lung-metastasizing tumor cells: identification as a transferrin. J Cell Biochem 47: 261–267PubMedGoogle Scholar
  20. Ceriani G, Macaluso A, Catania A, Lipton JM (1994) Central neurogenic anti-inflammatory action of alpha-MSH: modulation of peripheral inflammation induced by cytokines and other mediators of inflammation. Neuroendcrinology 59: 138–143Google Scholar
  21. Chao MV (1992) Neurotrophin receptors: a window into neuronal differentiation. Neuron 9: 583–593PubMedGoogle Scholar
  22. Connor JR, Menzies SL, St Martin SM, Mufson EJ (1990) Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains. J Neurosci Res 27: 595–611PubMedGoogle Scholar
  23. Constam DB, J.P, Maltipiero UV, ten Dijke P, Schachner M, Fontana A (1992) Differential expression of transforming growth factor-beta 1, -beta 2, and -beta 3 by glioblastoma cells, astrocytes, and microglia. J Immunol 148: 1404–1410PubMedGoogle Scholar
  24. Crowley C, Spencer SD, Nishimura MC, Chen KS, Pitts-Meek S, Armanini, MP, Ling LH, MacMahon SB, Shelton DL, Levinson AD, Phillips HS (1994) Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell 76: 1001–1011PubMedGoogle Scholar
  25. DiCicco BE, Friedman WJ, Black IB (1993) NT-3 stimulates sympathetic neuroblast proliferation by promoting precursor survival. Neuron 11: 1101–1111Google Scholar
  26. Dobrowsky RT, Werner MH, Castellino AM, Chao MV, Hannun YA (1994) Activation of the sphyngo-myelin cycle through the low-affinity neurotrophin receptor. Science 265: 1596–1599PubMedGoogle Scholar
  27. Eberle AN, Siegrist W, Bagutti C, Chluba-De Tapia J, Solca F, Wikberg JE, Chhajlani V (1993) Receptors for melanocyte stimulating hormone on melanoma cells. Ann NY Acad Sci 680: 320–341PubMedGoogle Scholar
  28. Ernfors P, Lee KF, Kucera J, Jaenisch R (1994a) Lack of neurotrophin-3 leads to deficiencies in the peripheral nervous system and loss of limb proprioceptive afferents. Cell 77: 503–512PubMedGoogle Scholar
  29. Ernfors P, Lee KF, Jaenisch R (1994b) Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature 368: 147–150PubMedGoogle Scholar
  30. Fabry Z, Fitzsimmons KM, Herlein JA (1993) Production of the cytokines interleukin 1 and 6 by murine brain microvessel endothelium and smooth muscle pericytes. J Neuroimmunol 4: 23–34Google Scholar
  31. Feinstein DL, Larhammar D (1990) Identification of a conserved protein motif in a group of growth factor receptors. FEBS Lett 272: 7–11PubMedGoogle Scholar
  32. Fischer HG, Nitzgen B, Germannt T (1993) Differentiation driven by granulocyte-macrophage colony-stimulating factor endows microglia with interferon-gamma-independent antigen presentation function. J Neuroimmunol 42: 87–95PubMedGoogle Scholar
  33. Frank E, Pulver M, DeTribolet N (1986) Expression of class II major histocompatability antigens on reactive astrocytes and endothelial cells within gliosis surrounding metastases and abscesses. J Neuroimmunol 12: 29–36PubMedGoogle Scholar
  34. Fressinaud C, Laeng P, Labourdette G, Durand J, Vallat JM (1993) The proliferation of mature oligodendrocytes in vitro is stimulated by basic fibroblast growth factor and inhibited by oligodendrocyte-type 2 astrocyte precursors. Dev Biol 158: 317–329PubMedGoogle Scholar
  35. Fujimaki T, Fan D, Staroselsky AH, G, ohji K, Bucana CD, Fidler IJ (1993) Critical factors regulating site-specific brain metastasis of murine melanomas. Int J Oncol 3: 789–799PubMedGoogle Scholar
  36. Hantzopoulos PA, Chitra S, Glass DJ, Goldfarb MP, Yancopoulos GD (1994) The low affinity NGF receptor, p75, can collaborate with each of the trks to potentiate functional responses to the neurotrophins. Neuron 13: 187–201PubMedGoogle Scholar
  37. Hempstead BL, Schleifer LS, Chao MV (1989) Expression of functional nerve growth factor receptorsafter gene transfer. Science 243: 373–375PubMedGoogle Scholar
  38. Hempstead BL, Patil N, Thiel B, Chao MV (1990) Deletion of cytoplasmic sequences of the nerve growth factor receptor leads to loss of high affinity ligand binding. J Biol Chem 265: 9595–9598PubMedGoogle Scholar
  39. Hempstead BL, Martin ZD, Kaplan DR, Parada LF, Chao MV (1991) High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature 350: 678–683PubMedGoogle Scholar
  40. Herlyn M, Thurin J, Balaban G, Bennicelli JL, Herlyn D, Elder DE, Bondi E, Guerry D, Nowell P, Clark WH, Koprowski H (1985) Characteristics of cultured human melanocytes isolated from different stages of tumor progression. Cancer Res 45: 5670–5676PubMedGoogle Scholar
  41. Herlyn M, Kath R, Williams N, Valyi-Nagy I, Rodeck U (1989) Growth regulatory factors for normal, premalignant and malignant human cells. Adv Cancer Res 54: 213–234Google Scholar
  42. Herrmann JL, Menter DG, Hamada J, Nakajima M, Nicolson GL (1993) Mediation of NGF-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: melanoma p75 functions independently of trkA. Mol Biol Cell 4: 1205–1216PubMedGoogle Scholar
  43. Hiltz ME, Catania A, Lipton JM (1992) Alpha-MSH peptides inhibit acute inflammation induced in mice by rlL-1 beta, rlL-6, rTNF-alpha and endogenous pyrogen but not that caused by LTB-4, PAF and rlL- 8. Cytokine 4: 320–328PubMedGoogle Scholar
  44. Hirano A, Kawanami T, Llena JF (1994) Electron microscopy of the blood brain barrier. Microsc Res Tech 27: 543–556PubMedGoogle Scholar
  45. Hunter KE, Sporn MB, Davies AM (1993) Transforming growth factor-betas inhibit mitogen-stimulated proliferation of astrocytes. Glia 7: 203–211PubMedGoogle Scholar
  46. Inoue T, Cavanaugh PG, Steck PA, Brunner N, Nicolson GL (1993) Differences in transferrin response and numbers of transferrin receptors in rat and human mammary carcinoma lines of different metastatic potentials. J Cell Physiol 156: 212–217PubMedGoogle Scholar
  47. Jegou S, Blasquez C, Delbende C, Bunel DT, Vaudry H (1993) Regulation of a-melanocyte-stimulating hormone release from hypothalmic neurons. Ann NY Acad Sci 680: 260–278PubMedGoogle Scholar
  48. Jia LB, Cavanaugh PG, Nicolson GL (1994) Paracrine growth factors for metastatic breast cancer cells: cloning of three new transferrin-like growth factor cDNAs that may be involved in the growth stimulation of breast cancer cells at secondary sites. Proc Am Assoc Cancer Res 35: 44Google Scholar
  49. Johnson D, Lanahan A, Buck CR, Chow M (1986) Expression and structure of the human NGF receptor. Cell 47: 545–554PubMedGoogle Scholar
  50. Jones KR, Farinas I, Backus C, Reichardt LF (1994) Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell 76: 989–999PubMedGoogle Scholar
  51. Kalcheim C, Carmeli C, Rosenthal A (1992) Neurotrophin 3 is a mitogen for cultured neural crest cells. Proc Natl Acad Sci USA 89: 1661–1665PubMedGoogle Scholar
  52. Kameyama K, Vieira WD, Tsukamoto K, Law LW, Hearing VJ (1990) Differentiation and the tumorigenic and metastatic phenotype of murine melanoma cells. Int J Cancer 45: 1151–1158PubMedGoogle Scholar
  53. Kannan Y, Usami K, Okada M, Shimizu S, Matsuda H (1992) Nerve growth factor suppresses apoptosis of murine neutrophils. Biochem Biophys Res Commun 186: 1050–1056Google Scholar
  54. Kettenmann H, Orkand RK, Schachner M (1983) Coupling among identified cells in mammalian nervous system cultures. J Neurosci 3: 506–516PubMedGoogle Scholar
  55. Kimelberg HK, Ransom BR (1986) Physiological aspects of astrocyte swelling. In: Fedoroff S, Verandakis A (eds) Astrocytes. Academic, Orlando, pp 129–166 Klatzo I, Chui E, Fujiwara K, Spatz M (1980) Resolution of vasogenic brain edema (VBE). Adv Neurol 28: 359–373Google Scholar
  56. Klein R, Smeyne RJ, Wurst W, Long LK, Auerbach BA, Joyner AL, Barbacid M (1993) Targeted disruption of the trkB neurotrophin receptor gene results in nervous system lesions and neonatal death. Cell 75: 113–122PubMedGoogle Scholar
  57. Klein R, Silos-Santiago I, Smeyne RJ, Lira SA, Brambilla R, Bryant S, Zhang L, Spider WD, Barbacid M (1994) Distruption of the neurotrophin-3 receptor gene trkC eliminates la muscle afferents and results in abnormal movements. Nature 368: 249–251PubMedGoogle Scholar
  58. Knipper M, Beck A, Rylett J, Breer H (1993) Neurotrophin induced cAMP and IP3 responses in PC12 cells. Different pathways. FEBS Lett 324: 147–52PubMedGoogle Scholar
  59. Kristt DA, Reedy E, Yarden Y (1993) Receptor tyrosine kinase expression in astrocytic lesions: similar features in gliosis and glioma. Neurosurgery 33: 106–115PubMedGoogle Scholar
  60. Lange-Carter CA, Johnson GL (1994) Ras-dependent growth factor regulation of MEK kinase in PC12 cells. Science 265: 1458–1461PubMedGoogle Scholar
  61. Lantos PL, Luthert PJ, Deane BR (1984) Vascular permeability and cerebral oedema in experimental brain tumors. In: Inaba Y, Klatzo I, Spatz M (eds) Brain edema. Springer, Berlin Heidelberg New York, pp 40–47Google Scholar
  62. Lee KF, Li E, Huber LJ, Landis SC, Sharpe AH, Chao MV, Jaenisch R (1992) Targeted mutation of the gene encoding the low affinity NGF receptor p75 leads to deficits in the peripheral sensory nervous system. Cell 69: 737–749PubMedGoogle Scholar
  63. Lee KF, Bachman K, Landis S, Jaenisch R (1994) Dependence on p75 for innervation of some sympathetic targets. Science 263: 1447–1449PubMedGoogle Scholar
  64. Leevers SJ, Paterson HF, Marshall CJ (1994) Requirement for Ras in Raf activation is overcome by targeting Raf to the plasma membrane. Nature 369: 411–414PubMedGoogle Scholar
  65. Lindholm D, Hengerer B, Zafra F, Theonin H (1990) Transforming growth factor-beta 1 stimulates expression of nerve growth factor in the rat CNS. Neuroreport 1: 9–12PubMedGoogle Scholar
  66. Lindholm D, Castren E, Kiefer R, Zafra F, Thoenen H (1992) transforming growth factor-beta 1 in the rat brain: increase after injury and inhibition of astrocyte poliferation. J Cell Biol 117: 395–400PubMedGoogle Scholar
  67. Lu C, Vickers MF, Kerbel R (1992) Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression. Proc Natl Acad Sci USA 89: 9215–9219PubMedGoogle Scholar
  68. Maher PA (1988) Nerve growth factor induces protein-tyrosine phosphorylation. Proc Natl Acad Sci USA 85: 6788–6791PubMedGoogle Scholar
  69. Marchetti D, Menter D, Jin L, Nakajima M, Nicolson GL (1993) Nerve growth factor effects on human and mouse melanoma cell invasion and heparanase production. Int J Cancer 55: 692–699PubMedGoogle Scholar
  70. Marchetti D, McCutcheon IE, Ross ML, Nicolson GL (1995) Inverse expression of neurotrophins and neurotrophin receptors at the invasion front of human melanoma brain metastases. Int J Oncol 7: 87–94PubMedGoogle Scholar
  71. Meakin SO, Shooter EM (1991) Molecular investigations on the high-affinity nerve growth factor receptor. Neuron 6: 153–163PubMedGoogle Scholar
  72. Meakin SO, Shooter EM (1992) The nerve growth factor family of receptors. Trends Neurosci 15: 323–331PubMedGoogle Scholar
  73. Menter DG, Herrmann JL, Nicolson GL (1995a) The role of trophic factors and autocrine/paracrine growth factors in brain metastasis. Clin Exp Metastasis 13: 67–88PubMedGoogle Scholar
  74. Menter DG, Herrmann JL, Marchetti D, Nicolson GL (1995b) Involvement of neurotrophins and growth factors in brain metastasis formation. Invasion Metastasis 14: 372–384Google Scholar
  75. Menter DG, Herrmann JL, Nicolson GL (1994) The metastatic melanoma neurotrophin receptor (p75) is a cell survival (menocytosis) receptor. Clin Exp Metastasis 12: 82aGoogle Scholar
  76. Merrill JE (1992) Tumor necrosis factor alpha, interleukin 1 and related cytokines in brain development: normal and pathological. Dev Neurosci 14: 1–10PubMedGoogle Scholar
  77. Mescher AL, Muniam SI (1988) Transferrin and the growth-promoting effect of nerves. Int Rev Cytol 110: 1–26PubMedGoogle Scholar
  78. Miyasaka T, Chao MV, Sherline P, Saltiel AR (1990) Nerve growth factor stimulates a protein kinase in PC-12 cells that phosphorylates microtubule-associated protein-2. J Biol Chem 265: 4730–4735PubMedGoogle Scholar
  79. Morris CM, Candy JM, Bloxham CA, Edwardson JA (1992) Immunocytochemical localisation of transferrin in the human brain. Acta Anat (Basel) 143: 14–18Google Scholar
  80. Morse HG, Gonzalez R, Moore GE, Robinson WA (1992) Preferential chromosome 11 q and or 17q aberrationsin short-term cultures of the metastatic melanoma resections from the brain. Cancer Genet Cytogenet 64: 118–126PubMedGoogle Scholar
  81. Mountjoy KG, Robbins LS, Mortrund MT, Cone RD (1992) The cloning of a family of genes that encode the melanocortin receptors. Science 257: 1248–1251PubMedGoogle Scholar
  82. Nicolson GL (1987) Tumor cell instability, diversification and progression to the metastatic phenotype: from oncogene to oncofetal expression. Cancer Res 47: 1473–1487PubMedGoogle Scholar
  83. Nicolson GL (1988) Cancer metastasis: Tumor cell and host organ properties important in colonization of specific secondary sites. Biochim Biophys Acta 948: 175–224PubMedGoogle Scholar
  84. Nicolson GL (1993a) Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis. Cancer Metastasis Rev 12: 325–343PubMedGoogle Scholar
  85. Nicolson GL (1993b) Cancer progression and growth: Relationship of paracrine and autocrine growth mechanisms to organ preference of metastasis. Exp Cell Res 204: 171–180PubMedGoogle Scholar
  86. Nicolson GL (1993c) Paracrine/autocrine growth mechanisms in tumor metastasis. Oncol Res 4: 389–399Google Scholar
  87. Nicolson GL, Inoue T, Van Pelt C; Cavanaugh PG (1990) Differential expression of a Mr 90,000 cell surface transferrin-related glycoprotein on murine B16 metastatic melanoma sublines selected for enhanced brain or ovary colonization. Cancer Res 50: 515–520PubMedGoogle Scholar
  88. Nicolson GL, Nakajima M, Herrmann JL, Menter DG, Cavanaugh PG, Park JS, Marchetti D (1994a) Malignant melanoma metastasis to brain: role of degradative enzymes and responses to paracrine growth factors. J Neurooncol 18: 139–149PubMedGoogle Scholar
  89. Nicolson GL, Menter D, Herrmann J, Cavanaugh P, Jia L-B, Hamada J, Yun Z, Marchetti D (1994b) Tumor metastasis to brain: role of endothelial cells, neutrophins and paracrine growth factors. Crit Rev Oncogenesis 15: 451–471Google Scholar
  90. Norenberg MD (1994) Astrocyte responses to CNS injury. J Neuropathol Exp Neurol 53: 213–220PubMedGoogle Scholar
  91. Nowell PC (1976) The clonal evolution of tumor cell. Science 194: 23–28PubMedGoogle Scholar
  92. Obermeier A, Lammers R, Wiesmuller KH, Jung G, Schlessinger J, Ullrich A (1993) Identification of Trk binding sites for SHC and phosphatidylinositol 3’-kinase and formation of a multimeric signaling complex. J Biol Chem 268: 22963–22966PubMedGoogle Scholar
  93. Obermeier A, Bradshaw RA, Seedorf K, Choidas A, Schlessinger J, Ullrich A (1993) Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC-gamma. EMBO J 13: 1585–1590Google Scholar
  94. Oh YJ, Markelonis GJ, Oh TH (1993) Effects of interleukin-1 beta and tumor necrosis factor-alpha on the expression of glial fibrillary acidic protein and transferrin in cultured astrocytes. Glia 8: 77–86PubMedGoogle Scholar
  95. Ohmichi M, Decker SJ, Pang L, Saltiel AR (1991) Phospholipase C-gamma 1 directly associates with the p70 trk oncogene product through its src homology domains J Biol Chem 266: 14858–14861PubMedGoogle Scholar
  96. Ohmichi M, Decker SJ, Saltiel AR (1992a) Nerve growth factor stimulates the tyrosine phosphorylation of a 38-kDa protein that specifically associates with the src homology domain of phospholipase C-gamma 1. J Biol Chem 267: 21601–21606PubMedGoogle Scholar
  97. Ohmichi M, Decker SJ, Saltiel AR (1992b) Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology-2 domains. Neuron 9: 769–777PubMedGoogle Scholar
  98. Ohmichi M, Pang L, Decker SJ, Saltiel AR (1992c) Nerve growth factor stimulates the activities of the raf-1 and the mitogen-activated protein kinases via the trk protooncogene. J Biol Chem 267: 14604–14610PubMedGoogle Scholar
  99. Ono T, Sato H, Kashimoto T, Okumoto T, Miyamoto K (1991) Stimulation of biosynthesis of nerve growth factor by acidic fibroblast growth factor in cultured mouse astrocytes. Neurosci Lett 126: 18–20PubMedGoogle Scholar
  100. Orita T, Akimura T, Nishizaki T, Kamiryo T, Ikeyama Y, Aoki H, Ito H (1990) Transferrin receptors in injured brain. Acta Neuropathol (Berl) 79: 686–688Google Scholar
  101. Peacocke M, Yaar M, Mansur CP, Chao MV, Gilchrest BA (1988) Induction of nerve growth factor receptors pn cultured human melanocytes. Proc Natl Acad Sci USA 85: 5282–5286PubMedGoogle Scholar
  102. Rabizadeh S, Oh J, Zhong LT, Yang J, Bitler CM, Butcher LL, Bredesen DE (1993) Induction of apoptosis by the low-affinity NGF receptor. Science 261: 345–348PubMedGoogle Scholar
  103. Raff CM (1992) Social controls on cell survival and cell death. Nature 356: 397–400PubMedGoogle Scholar
  104. Raff MC, Barres BA, Burne JF, Coles HS, Ishizaki Y, Jacobson MD (1993) Programmed cell death and the control of cell survival: lessons from the nervous system. Science 262: 695–700PubMedGoogle Scholar
  105. Rodeck U, Herlyn M (1991) Growth factors in melanoma. Cancer Met Rev 10: 89–101Google Scholar
  106. Ross AH, Grob P, Bothwell M, Elder DE, Ernst CS, Marano N, Ghrist BF, Slemp CC, Herlyn M, Atkinson B, Koprowski H (1984) Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies. Proc Natl Acad Sci USA 81: 6681–6685PubMedGoogle Scholar
  107. Rozakis-Adcock M, McGlade J, Mbamalu G, Pelicci G, Daly R, Li W, Batzer A, Thomas S, Brugge J, Pelicci PG, Schlessinger J, Pawson T (1992) Association of the She and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature 360: 689–692PubMedGoogle Scholar
  108. Salomon Y, Zohar M, Dejordy JO, Eshel Y, Shafir I, Leiba H, Garty NB, Schmidt-Sole J, Azrad A, Shai E, Degani H (1993) Signaling mechanisms controlled by melanocortins in melanoma, lacrimal and brain astroglial cells. In: Vaudry H, Eberle AN (eds) The melanotropic peptides. Ann NY Acad Sci 680: 364–379Google Scholar
  109. Sawada M, Suzumura A, Marunochi T (1992) TNF alpha induces IL-6 production by astrocytes but not by microglia. Brain Res 583: 296–299PubMedGoogle Scholar
  110. Schnell L, Schneider R, Kolbeck R, Barde YA, Schwab ME (1994) Neurotrophin-3 enhances sprouting of corticospinal tract during development and after adult spinal cord lesion. Nature 367: 170–173PubMedGoogle Scholar
  111. Sendtner M, Arakawa Y, Stockli KA, Kreutzberg GW, Thoenen H (1991) Effect of ciliary neurotrophic factor (CNTF) on motoneuron survival. J Cell Sci Suppl 15: 103–109Google Scholar
  112. Siegrist W, Stutz S, Eberle AN (1994) Homologous and heterologous regulation of a-melanocyte stimulating hormone receptors in human and mouse melanoma cell lines. Cancer Res 54: 2604–2610PubMedGoogle Scholar
  113. Smeyne RJ, Klein R, Schnapp A, Long LK, Bryant S, Lewin A, Lira SA, Barbacid M (1994) Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature 368: 246–249PubMedGoogle Scholar
  114. Smith CA, Farrah T, Goodwin RG (1994) The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 76: 959–962PubMedGoogle Scholar
  115. Snider WD (1994) Functions of the neurotrophins during nervous system development: what knockouts are teaching us. Cell 77: 627–638PubMedGoogle Scholar
  116. Steck PA, Nicolson GL (1993) Metastasis to the central nervous system. In: Levine A, Schmidek H (eds) Molecular genetics of nervous system tumors. Wiley, New York, pp 371–379Google Scholar
  117. Stehlin JS, Hills WJ, Rufino C (1967) Disseminated melanoma: biologic behavior and treatment. Arch Surg 94: 495–501PubMedGoogle Scholar
  118. Stephens RM, Loeb DM, Copeland TD, Pawson T, Greene LA, Kaplan DR (1994) Trk receptors use redundant signal transduction pathways involving SHC and PLC-gamma 1 to mediate NGF responses. Neuron 12: 691–705PubMedGoogle Scholar
  119. Stokoe D, Macdonald SG, Cadwallader K, Symons M, Hancock JF (1994) Activation of Raf as a result of recruitment to the plasma membrane. Science 264: 1463–1467PubMedGoogle Scholar
  120. Sugarbaker EV (1981) Patterns of metastases in human malignancies. Cancer Biol Rev 2: 235–278Google Scholar
  121. Taylor LK, Swanson KD, Kerigan J, Mobley W, Landreth GE (1994) Isolation and characterization of a nerve growth factor-regulated Fos kinase from PC12 cells. J Biol Chem 269: 308–318PubMedGoogle Scholar
  122. Verdi JM, Birren SJ, Ibanez CF, Persson H, Kaplan DR, Benedetti M, Chao MV, Anderson DJ (1994) p75LNGFR regulates Trk signal transduction and NGF-induced neuronal differentiation in MAH cells. Neuron 12: 733–745PubMedGoogle Scholar
  123. Volonte C, Greene LA (1990) Induction of ornithine decarboxylase by nerve growth factor in PC12 cells: dissection by purine analogues. J Biol Chem 265: 11050–11055PubMedGoogle Scholar
  124. Volonte C, Greene LA (1992) Nerve growth factor-activated protein kinase N. Characterization and rapid near homogeneity purification by nucleotide affinity-exchange chromatography. J Biol Chem 267: 21663–21670PubMedGoogle Scholar
  125. Volente C, Ross AH, Greene LA (1993a) Association of a purine-analogue-sensitive protein kinase activity with p75 nerve growth factor receptors. Mol Biol Cell 4: 71–78Google Scholar
  126. Volente C, Angelastro JM, Greene LA (1993b) Association of protein kinases ERK1 and ERK2 with p75 nerve growth factor receptors. J Biol Chem 268: 21410–21415PubMedGoogle Scholar
  127. von Bartheld CS, Kinoshita Y, Prevette D, Yin QW, Oppenheim RW, Bothwell M (1994) Positive and negative effects of neurotrophins on the isthmo-optic nucleus in chick embryos. Neuron 12: 639–654Google Scholar
  128. Weskamp G, Reichardt LF (1991) Evidence that biological activity NGF is mediated through a novel subclass of high affinity receptors. Neuron 6: 649–663PubMedGoogle Scholar
  129. Wilken GP, Marriot DR, Chlolewinski AJ (1990) Astrocyte heterogeneity. Trends Neurosci 13: 43–46Google Scholar
  130. Wolff RA, Dobrowsky RT, Bielawaska A, Obeid LM, Hannun YA (1994) Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction. J Biol Chem 269: 19605–19609PubMedGoogle Scholar
  131. Wright DC, Delaney TF (1989) Treatment of metastatic cancer to the brain. In: DeVita VT, Hellman S, Rosenburg SA (eds) Cancer: principals and practice of oncology. Lippincott, New York, pp 2245–2261Google Scholar
  132. Yaar M, Eller MS, DiBenedetto P, Reenstra WR, Zhai S, McQuaid T, Archambault M, Gilchrest BA (1994) The trk family of receptors mediates nerve growth factor and neurotrophin-3 effects in melanocytes. J Clin Invest 94: 1550–1562PubMedGoogle Scholar
  133. Yaar M, Gilchrest BA (1991) Human melanocyte growth and differentiation: a decade of new data. J Invest Dermatol 97: 611–617PubMedGoogle Scholar
  134. Yoshida K, Gage FH (1991) Fibroblast growth factors stimulate nerve growth factor synthesis and secretion by astrocytes. Brain Res 538: 118–126PubMedGoogle Scholar
  135. Yoshida K, Gage FH (1992) Cooperative regulation of nerve growth factor synthesis and secretion in fibroblasts and astrocytes by fibroblast growth factor and other cytokines. Brain Res 569: 14–25PubMedGoogle Scholar
  136. Yoshida K, Kakihana M, Chen LS, Ong M, Baird A, Gage FH (1992) Cytokine regulation of nerve growth factor-mediated cholinergic neurotrophic activity synthesized by astrocytes and fibroblasts. J Neurochem 59: 919–931PubMedGoogle Scholar
  137. Zafra F, Lindholm D, Castren J, Thoenen H (1992) Regulation of brain-derived neurotrophic factor and nerve growth factor mRNA in primary cultures of hippocampal neurons and astrocytes. J Neurosci 12: 4793–4799PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • G. L. Nicolson
    • 1
  • D. G. Menter
    • 1
  • J. L. Herrmann
    • 1
  • Z. Yun
    • 1
  • P. Cavanaugh
    • 1
  • D. Marchetti
    • 1
  1. 1.Department of Tumor BiologyUniversity of Texas, MD Anderson Cancer CenterHoustonUSA

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