Angiogenesis-Regulating Cytokines: Activities and Interactions

  • M. S. Pepper
  • S. J. Mandriota
  • J.-D. Vassalli
  • L. Orci
  • R. Montesano
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 213/2)


The establishment of a vascular supply is an absolute requirement for the growth of normal and neoplastic tissues and, as might be expected, the cardiovascular system is the first organ system to develop and to become functional during embryogenesis. It has been known since the beginning of this century (Evans 1909) that, both during development and in postnatal life, all blood vessels begin as simple endothelial-lined capillaries. Although some remain as capillaries, many of these newly formed vessels develop into larger vessels, in part through the addition of a variable number of concentrically disposed smooth muscle cell layers. The heterogeneity and variable complexity of blood vessels thus generated serves to ensure structural and functional diversity in the vascular tree.


Endothelial Cell Vascular Endothelial Growth Factor Transform Growth Factor Basic Fibroblast Growth Factor Endothelial Cell Proliferation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • M. S. Pepper
    • 1
  • S. J. Mandriota
    • 1
  • J.-D. Vassalli
    • 1
  • L. Orci
    • 1
  • R. Montesano
    • 1
  1. 1.Department of MorphologyUniversity of Geneva Medical CenterGeneva 4Switzerland

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