Cytokine-Mediated Tumor-Endothelial Cell Interaction in Metastasis

  • R. Giavazzi
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 213/2)


A variety of adhesive interactions take place between tumor cells and host vasculature in tumor progression and metastasis (McCormick and Zetter 1992; Honn and Tang 1992; Belloni and Tressler 1990). Perhaps one of the most important adhesion events in the process of metastasis is the interaction of circulating tumor cells with the endothelium and subendothelial matrix (Liotta 1986; Kramer and Nicolson 1979). The arrest of tumor cells in the capillary bed of secondary organs, through the interaction with vascular or lymphatic endothelium and subendothelial basement membrane, precedes their migration into the tissue parenchyma; once extravasation has occurred, micrometastasis proliferation will start (Crissman et al. 1988). The adhesion to vascular endothelium is a necessary step preceding the extravasation of metastatic tumor cells. However, it is becoming increasingly clear that the preferential interaction between tumor cells and the microvascular endothelium and extracellular matrix of different areas contributes to the homing of metastases in specific organs (Pauli et al. 1990; Auerbach et al. 1987; Pauli and Lee 1988; Roos et al. 1984; Nicolson 1988). Attempts to identify endothelial cell surface components responsible for endothelial cell organ-specific interactions have been reported (Zhu et al. 1991; Belloni and Nicolson 1988).


Melanoma Cell Metastasis Formation Tumor Cell Adhesion Lung Coloni Mediate Tumor Cell Adhesion 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • R. Giavazzi
    • 1
  1. 1.Mario Negri Institute for Pharmacological ResearchBergamoItaly

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