NM23/Nucleoside Diphosphate Kinase as a Transcriptional Activator of c-myc

  • E. H. Postel
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 213/2)


Expression of the nm23 gene has been correlated with a variety of cellular mechanisms including tumor metastasis (Steeg et al. 1988; Nakayama et al. 1992, 1993), neoplastic development (Zynick et al. 1993), normal development and differentiation (Dearolf et al. 1988; Biggs et al. 1988, Wallet et al. 1990; Yamashiro et al. 1994), proliferation (Keim et al. 1992; Ohneda et al. 1994), and cell motility (Kantor et al. 1993). All nm 23 genes encode the metabolic enzyme nucleoside diphosphate kinase (NDPK), whose principal known function is to provide nucleoside triphosphate precursors for DNA and RNA synthesis. It has been proposed that NM23/NDPK proteins contain additional biochemical activities, for neither the developmental function of the Drosophila NM23/Awd protein (Biggs et al. 1988; Lascu et al. 1992), or the metastasis suppression effect of human NM23 (Sastre Garau et al. 1992; Steeg et al. 1993) correlates directly with NDPK levels or its activity.


Nucleoside Diphosphate Kinase NM23 Protein Gene Nm23 Nm23 Expression NDPK Activity 
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© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • E. H. Postel
    • 1
  1. 1.Department of Molecular BiologyPrinceton UniversityPrincetonUSA

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