Regulation of Tumor Angiogenesis by Organ-Specific Cytokines
The outcome of cancer metastasis is dependent on a series of interactions between tumor cells and host factors (Fidler 1990). A crucial step in tumor progression and metastasis is vascularization of the tumor and its immediate surroundings (Folkman 1992). Without the ability to recruit new blood vessels, it is likely that most tumors would not grow beyond 1–2 mm and thus remain localized at the primary site. The induction of neovascularization is mediated by both tumor cells and host cells and the interaction of the two. In this article, we will discuss these interactions in the regulation of the angiogenic phenotype and how organ-derived cytokines modulate the expression of angiogenic factors.
KeywordsMelanoma Cell Tumor Angiogenesis Human Melanoma Cell Vascular Endothelial Cell Growth Factor Human Renal Cell Carcinoma
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