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The CD44 Proteins in Embryonic Development and in Cancer

  • Chapter
Book cover Attempts to Understand Metastasis Formation I

Part of the book series: Current Topics in Microbiology 213/I and Immunology ((CT MICROBIOLOGY,volume 213/1))

Abstract

During the past decade, considerable advances have been made in our under­standing of the cellular and molecular biology of carcinogenesis. The analysis of the metastatic process, however, which is the chief contributor to cancer patient morbidity, has met with various obstacles due to its complexity. As a result, we still know very little about how cancer cells spread. It is generally assumed that cancer cells randomly diversify during tumor progression and that clones of such cells with metastatic properties are selected. The process by which these cells then metastasize is believed to occur via several steps, each of which can be linked to the aquisition of new cellular functions (see, e.g., reviews by Hart et al. 1989; Kerbel 1990). For example, a stationary epithelial cell must first be con­verted into a mobile, nonadherent cancer cell which can invade subepithelial tissue. The cell must then move towards lymphatic and blood vessels, enter these vessels, and survive during their transport within the fluid medium. It must also colonize draining lymphatic tissue and further disseminate through efferent lymphatics into the blood stream, extravasate from blood vessels and, finally, preferentially settle in various distant locations.

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Authors
  1. L. Sherman
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  2. J. Sleeman
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  3. P. Dall
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  4. A. Hekele
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  5. J. Moll
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  6. H. Ponta
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  7. P. Herrlich
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Editor information

Editors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstraße 487, CH-4005, Basel, Switzerland

    Ursula Günthert Ph.D., P.D.

  2. Max-βDelbrūck-Centrum für Molekulare Medizin, Robert-Rōssle-Straße 10, D-13122, Berlin, Germany

    Walter Birchmeier Ph.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Sherman, L. et al. (1996). The CD44 Proteins in Embryonic Development and in Cancer. In: Günthert, U., Birchmeier, W. (eds) Attempts to Understand Metastasis Formation I. Current Topics in Microbiology 213/I and Immunology, vol 213/1. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61107-0_15

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  • DOI: https://doi.org/10.1007/978-3-642-61107-0_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64697-3

  • Online ISBN: 978-3-642-61107-0

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