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Intrathekale Analgesie mit dem Somatostatinanalogon Octreotid

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Zusammenfassung

Mit der Entwicklung von Kathetersystemen und Pumpen zur kontinuierlichen Abgabe von Analgetika ist es möglich geworden, spinal wirksame Peptide zur Schmerzlinderung einzusetzen. Dieser Beitrag beschreibt erste Erfahrungen mit der Verwendung des Somatostatinanalogons Octreotid bei Krebspatienten.

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Literatur

  1. Chrubasik J (1985) Spinal infusion of opiates and somatostatin. Hygieneplan, Oberursel

    Google Scholar 

  2. Chrubasik J, Meynadier J, Blond S et al (1984) Somatostatin, a potent analgesic. Lancet II: 1208–1209

    Article  Google Scholar 

  3. Coombs DW, Tratkin JD, Meier FA (1985) neuropathologic lesions an CSF morphine concentrations during chronic continuous intraspinal morphine infusion. A clinical and post-mortem study. Pain 22: 337–351

    Article  PubMed  CAS  Google Scholar 

  4. Coombs DW, Sanders RL, Lachance D et al. (1985) Intrathecal morphine tolerance: use of intrathecal clonidine, DADLE, and intraventricular morphine. Anesthesiology 62: 358–363

    Article  PubMed  CAS  Google Scholar 

  5. Dahm LS, Beric A, Dimitrijevic MR et al. (1989) Direct spinal effect of a benzodiazepine (midazolam) on spasticity in man. Stereotact Funct Neurosurg 53: 85–94

    Article  PubMed  CAS  Google Scholar 

  6. Gaumann DM, Yaksh TL (1988) Intrathecal somatostatin in rats: antinociception only in the presence of toxic effects. Anesthesiology 68: 733–742

    Article  PubMed  CAS  Google Scholar 

  7. Griffiths EC, Jeffcoate SL, Holland DL (1977) Inactivation of somatostatin by peptidases in different areas of the rat brain. Acta Endocrinol (Copenh) 85: 1–10

    PubMed  CAS  Google Scholar 

  8. Kroin JS (1988) Which drugs, what space? Ann NY Acad Sci 531: 40–47

    Article  PubMed  CAS  Google Scholar 

  9. Krukoff TL, Ciriello J, Calaresu FR (1986) Somatostatin-like immunoreactivity in neurons, nerve terminals, and fibers of the cat spinal cord. J Comp Neurol 243: 13–22

    Article  PubMed  CAS  Google Scholar 

  10. Long JB (1988) Spinal subarachnoid injection of somatostatin causes neurological deficits and neuronal injury in rats. Eur J Pharmacol 149: 287–296

    Article  PubMed  CAS  Google Scholar 

  11. Mollenholt P, Rawal N, Gordh T, Olsson Y (1994) Intrathecal and epidural somatostatin for patients with cancer. Anesthesiology 81: 534–542

    Article  PubMed  CAS  Google Scholar 

  12. Penn RD (1992) Intrathecal baclofen for spasticity of spinal origin: seven years’ experience. J Neurosurg 77: 236–240

    Article  PubMed  CAS  Google Scholar 

  13. Penn RD, Paice JA, Gottshalk W et al. (1984) Cancer pain relief using chronic morphine infusion: early experience with a programmable implanted drug pump. J Neurosurg 61: 302–306

    Article  PubMed  CAS  Google Scholar 

  14. Penn RD, Paice JA, Kroin JS (1992) Octreotide: a potent new non-opiate analgesic for intrathecal infusion. Pain 49: 13–19

    Article  PubMed  CAS  Google Scholar 

  15. Pless J, Bauer W, Briner W et al (1986) Chemistry and pharmacology of SMS 201-995, a long-acting octapeptide analogue of somatostatin. Scand J Gastroenterol [Suppl] 21: 54–64

    Article  Google Scholar 

  16. Randic M, Miletic V (1987) Depressant actions of methionine-enkephalin and somatostatin in the cat dorsal horn neurones activated by noxious stimuli. Brain Res 152: 196–202

    Article  Google Scholar 

  17. Sandkühler J, Fu Q-G, Helmchen C (1990) Spinal somatostatin superfusion in vivo affects activity of cat nociceptive dorsal horn neurons: comparison with spinal morphine. Neuroscience 34: 565–576

    Article  PubMed  Google Scholar 

  18. Taura P, Planella V, Balust J, Beltran J, Anglada T, Carrero E, Burgues S (1994) Epidural somatostatin as an analgesic in upper abdominal surgery: a doubleblind study. Pain 59: 135–140

    Article  PubMed  CAS  Google Scholar 

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© 1996 Springer-Verlag Berlin Heidelberg

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Penn, R.D. (1996). Intrathekale Analgesie mit dem Somatostatinanalogon Octreotid. In: Chrubasik, S., Martin, E. (eds) Zur Behandlung akuter und chronischer Schmerzen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61066-0_14

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  • DOI: https://doi.org/10.1007/978-3-642-61066-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60496-9

  • Online ISBN: 978-3-642-61066-0

  • eBook Packages: Springer Book Archive

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