Skip to main content
SpringerLink
Log in

Naturally Occurring Pulmonary Tumors in Rodents

  • Chapter
Respiratory System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

The development of naturally occurring lung tumors is related to aging. In rats, mice, and hamsters younger than 12 months naturally occurring pulmonary tumors are exceedingly rare. The majority of them are found in animals older than 20 months. Even then the prevalence in rats and Syrian hamsters is very low whereas in certain strains of mice pulmonary tumors occur quite frequently. The interpretation of long-term animal studies resulting in primary neoplasms of the respiratory tract requires classification of tumors. Because most long-term studies are carried out in rats, the recent literature contains more reports on classification and description of lung tumors for this species.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adamson IYR, Bowden DH (1979) Bleomycin-induced injury and metaplasia of alveolar type 2 cells. Relationship of cellu¬lar responses to drug presence in the lung. Am J Pathol 96:531–544

    PubMed  CAS  Google Scholar 

  • Addis BJ (1988) Pathology of lung cancer. In: Hoogstraten B, Addis BJ, Hansen HH, Martini N, Spiro SG (eds) UICC series. Current treatment of cancer. Lung tumors: lung, mediastinum, pleura, and chest wall. Springer, Berlin Heidelberg New York, pp 17–36

    Google Scholar 

  • Anderson LM, Budinger JM (1981) Qualitative histological differences between transplacentally-induced lung tumors in young and aging mice. Cancer Lett 11:285–293

    Article  PubMed  CAS  Google Scholar 

  • Anver MR, Cohen BJ, Lattuada CP, Foster SJ (1982) Age-associated lesions in barrier-reared male Sprague-Dawley rats: a comparison between Hap: (SD) and Crl:COBS[R]CD[R](SD) stocks. Exp Aging Res 8:3–23

    PubMed  CAS  Google Scholar 

  • Becci PJ, McDowell EM, Trump BF (1978) The respiratory epithelium. IV. Histogenesis of epidermoid metaplasia and carcinoma in situ in the hamster. J Natl Cancer Inst 61:577–586

    PubMed  CAS  Google Scholar 

  • Beer DG, Malkinson AM (1985) Genetic influence on type 2 or Clara cell origin of pulmonary adenomas in urethane treated mice. J Natl Cancer Inst 75:963–969

    PubMed  CAS  Google Scholar 

  • Belinsky SA, Foley JF, White CM, Anderson MW, Maronpot RR (1990) Dose-response relationship between 06-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4(methylnitrosamino)-1-(3-pyridyl)-1-butanone. Cancer Res 50:3772–3780

    PubMed  CAS  Google Scholar 

  • Belinsky SA, Devereux TR, Foley JF, Maronpot RR, Anderson MW (1992) Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone in the A/J mouse. Cancer Res 52:3164–3173

    PubMed  CAS  Google Scholar 

  • Blair WH (1974) Chemical induction of lung carcinomas in rats. In: KarbeE,Park JF (eds) Experimental lung cancer: international symposium on experimental lung cancer carcinogenesis and bioassay. Springer, Berlin Heidelberg New York, pp 199–206

    Google Scholar 

  • Bomhard E (1992) Frequency of spontaneous tumors in Wistar rats in 30-months studies. Exp Toxicol Pathol 44:381–392

    PubMed  CAS  Google Scholar 

  • Bomhard E, Mohr U (1989) Spontaneous tumours in NMRI mice from carcinogenicity studies. Exp Pathol 36:129–145

    PubMed  CAS  Google Scholar 

  • Bomhard E, Rinke M (1994) Frequency of spontaneous tumours in Wistar rats in 2-year studies. Exp Toxicol Pathol 46:17–29

    PubMed  CAS  Google Scholar 

  • Bomhard E, Karbe E, Loeser E (1986) Spontaneous tumors of 2000 Wistar TNO/W.70 rats in two-year carcinogenicity studies. J Environ Pathol Toxicol Oncol 7:35–52

    PubMed  CAS  Google Scholar 

  • Boorman GA, Eustis SL (1990) Lung. In: BoormanGA, EustisSL,ElwellMR,MontgomeryCA,MacKenzieWF (eds) Pathology of the Fischer rat: reference and atlas. Academic, San Diego, pp 339–367

    Google Scholar 

  • Branstetter DG, Moseley PP (1991) Effect of lung development on the histological pattern of lung tumors induced by ethylnitrosourea in the C3HeB/FeJ mouse. Exp Lung Res 17:169–179

    Article  PubMed  CAS  Google Scholar 

  • Branstetter DG, Stoner GD, Budd C, Conran PB, Goldblatt PJ (1988) Effect of gestational development of lung tumor size and morphology in the mouse. Cancer Res 48:379–386

    PubMed  CAS  Google Scholar 

  • Carlton WW, Ernst H, Faccini JM, GreavesP,KrinkeGJ,LongPH,MaekawaA,NewsholmeSJ, WeisseG (1992) Soft tissue and musculoskeletal system. In: MohrU,CapenCC,DungworthDL,GriesemerRA,ItoN,TurusovVS (eds) International classification of rodent tumors, part 1: the rat. IARC Sci Pubi 122:1–62

    Google Scholar 

  • Chandra M, Frith CH (1992a) Spontaneous neoplasms in aged CD-I mice. Toxicol Lett 61:67–74

    Article  CAS  Google Scholar 

  • Chandra M, Frith CH (1992b) Spontaneous neoplasms in aged control Fischer 344 rats. Cancer Lett 62:49–56

    Article  CAS  Google Scholar 

  • Chandra M, Frith CH (1992c) Spontaneous neoplasms in B6C3F1 mice. Toxicol Lett 60:91–98

    Article  CAS  Google Scholar 

  • Chandra M, Riley MGI, Johnson DE (1992) Spontaneous neoplasms in aged Sprague-Dawley rats. Arch Toxicol 66:496–502

    Article  PubMed  CAS  Google Scholar 

  • Deerberg F, Rapp K, Pittermann W, Rehm S (1980) Zum Tumorspektrum der HamWIST Ratte. Z Versuchstierkd 22:267–280

    PubMed  CAS  Google Scholar 

  • Dixon D, Maronpot RR (1991) Histomorphologic features of spontaneous and chemically-induced pulmonary neoplasms in B6C3FX mice and Fischer 344 rats. Toxicol Pathol 19:540–556

    Article  PubMed  CAS  Google Scholar 

  • Dixon D, Horton J, Haseman JK, Talley F, Greenwell A, Nettesheim P, Hook GE, Maronpot RR (1991) Histomorphology and ultrastructure of spontaneous pulmonary neoplasms in strain A mice. Exp Lung Res 17:131–155

    Article  PubMed  CAS  Google Scholar 

  • Dungworth DL (1985) The respiratory system. In: JubbKVF,KennedyPC,PalmerN (eds) Pathology of domestic animals, 3rd edn. Academic, Orlando, pp 413–556

    Google Scholar 

  • Dungworth DL, Hahn FF, Hayashi Y, Keenan K, Mohr U, Rittinghausen S, Schwartz L (1992) Respiratory system. In: MohrU,CapenCC, DungworthDL,Griesemer RA,ItoN,TurusovVS (eds) International classification of rodent tumours, part I: the rat. IARC Sci Pubi 122:1–57

    Google Scholar 

  • Dungworth DL, Mohr U, Heinrich U, Ernst H, KittelB (1994) Pathologie effects of inhaled particles in rat lungs: associations between inflammatory and neoplastic processes. In: MohrU,DungworthDL,MauderlyJL,OberdörsterG (eds) Toxic and carcinogenic effects of solid particles in the respiratory tract. International Life Sciences Institute, Washington DC, pp 75–98

    Google Scholar 

  • Dungworth DL, Harkema J, Hayashi Y, Kittel B, Lewis D, Miller R, Mohr U, Morgan K, Rehm S, Rittinghausen S, Schwartz L, Slayter M. Respiratory system and mesothelium. In: Mohr U, Capen CC, Dungworth DL, Griesemer RA, Hardisty J, Ito N, Long P, Turusov VS (eds) International classification of rodent tumours, part II: the mouse. IARC Sci Pubi (in preparation)

    Google Scholar 

  • Emura M, DaCosta C (1993) In vitro investigation on proliferative cystic keratinizing squamous lesions in the rat lung. Exp Toxicol Pathol 45:189–195

    PubMed  CAS  Google Scholar 

  • Faccini JM, Abbott DP, Paulus GJJ (1990) Respiratory tract. Mouse histopathology. Elsevier, Amsterdam New York, pp 48–63

    Google Scholar 

  • Frith CH (1987) Incidence of neoplastic and nonneoplastic lesions in several strains of mice. Toxicology Pathology Associates, Little Rock, pp 1–57

    Google Scholar 

  • Frith CH, Littlefield NA, Umholtz R (1981) Incidence of pulmonary metastases for various neoplasms in BALB/ cStCr1fC3H/Nctr female mice fed N-2-fìuorenylacetamide. J Natl Cancer Inst 66:703–712

    PubMed  CAS  Google Scholar 

  • Frith CH, Highman B, Burger GT, Sheldon WD (1983) Spontaneous lesions in virgin and retired breeder BALB/c and C57BL/6 mice. Lab Anim Sci 33:273–286

    PubMed  CAS  Google Scholar 

  • Goodman DG, Ward JM, Squire RA, Chu KC, Linhart MS (1979) Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol Appi Pharmacol 48: 237–248

    Article  CAS  Google Scholar 

  • Goodman DG, Ward JM, Squire RA, Paxton MB, Reichardt WD, Chu KC, Linhart MS (1980) Neoplastic and nonneoplastic lesions in aging Osborne-Mendel rats. Toxicol Appi Pharmacol 55:433–447

    Article  CAS  Google Scholar 

  • Gunning WT, Castonguay A, Goldblatt PJ, Stoner GD (1991) Strain A/J mouse lung adenoma growth patterns vary when induced by different carcinogens. Toxicol Pathol 19:168–175

    Article  PubMed  CAS  Google Scholar 

  • Gunning WT, Goldblatt PJ, Stoner GD (1992) Keratin expression in chemically induced mouse lung adenomas. Am J Pathol 140:109–118

    PubMed  CAS  Google Scholar 

  • Hahn FF (1985) Radiation-induced squamous cell carcinoma, lung of rodents. In: JonesTC,MohrU,HuntRD (eds) Monographs on pathology of laboratory animals. Respiratory system. Springer, Berlin Heidelberg New York, pp 127–133

    Google Scholar 

  • Hahn FF, Lundgren DL (1992) Pulmonary neoplasms in rats that inhaled cerium-144 dioxide. Toxicol Pathol 20:169–178

    Article  PubMed  CAS  Google Scholar 

  • Haseman JK, Huff J, Boorman GA (1984) Use of historical control data in carcinogenicity studies in rodents. Toxicol Pathol 12:126–135

    Article  PubMed  CAS  Google Scholar 

  • Haseman JK, Huff JE, Rao GN, ArnoldJE,BoormanGA,McConnellEE (1985) Neoplasms observed in untreated and corn oil gavage control groups of F344/N rats and (C57BL/ 6N X C3H/HeN)F1 (B6C3F1) mice. J Natl Cancer Inst 75:975–984

    PubMed  CAS  Google Scholar 

  • Haseman JK, Arnold J, Eustis SL (1990) Tumor incidences in Fischer 344 rats: NTP historical data. In: BoormanGA,EustisSL,ElwellMR,MontgomeryCA, MacKenzieWF (eds) Pathology of the Fischer rat. Academic, San Diego, pp 555–564

    Google Scholar 

  • Heath JE, Frith CH, Wang PM (1982) A morphologic classification and incidence of alveolar-bronchiolar neoplasms in BALB/c female mice. Lab Anim Sci 32:638–647

    PubMed  CAS  Google Scholar 

  • Herbert RA, Gillett NA, Rebar AH, Lundgren DL, Hoover MD, Chang IY, CarltonWW,HahnFF (1993) Sequential analysis of the pathogenesis of plutonium-induced pulmonary neoplasms in the rat: morphology, morphometry, and cytokinetics. Radiai Res 134:29–42

    Article  CAS  Google Scholar 

  • Homburger F, Russfield AB, Weisburger JH, Lim S, Chak SP, Weisburger EK (1975) Aging changes in CD-I HaM/ICR mice reared under standard laboratory conditions. J Natl Cancer Inst 55:37–45

    PubMed  CAS  Google Scholar 

  • Ito T (1985) An ultrastructural study of the acute effects of 4-nitroquinoline 1-oxide on the hamster lung. Exp Mol Pathol 42:220–233

    Article  PubMed  CAS  Google Scholar 

  • Ito T, Kitamura H, Inayama Y, Kanisawa M (1988) Pulmonary adenoma and endocrine cell hyperplasia in Syrian golden hamster treated with 4-nitroquinoline 1-oxide. Acta Pathol Jpn 38:1097–1104

    PubMed  CAS  Google Scholar 

  • Ito T, Ikemi Y, Kitamura H, OgawaT,KanisawaM (1989) Production of bronchial papilloma with calcitonin-like immunoreactivity in rats exposed to urban ambient air. Exp Pathol 36:89–96

    PubMed  CAS  Google Scholar 

  • Kamino K, Mohr U (1993) Frequency of metastasis depending on histologic type of primary lung carcinoma in rats. J Exp Anim Sci 35:161–165

    PubMed  CAS  Google Scholar 

  • Kaspareit-Rittinghausen J, DeerbergF (1988) High frequency of spontaneous histiocytic sarcomas in BDII/Han rats. J Comp Pathol 99:299–307

    Article  PubMed  CAS  Google Scholar 

  • Kauffman SL (1981) Histogenesis of the papillary Clara cell adenoma. Am J Pathol 103:174–180

    PubMed  CAS  Google Scholar 

  • Kauffman SL, Sato T (1985) Bronchiolar adenoma, lung, mouse. In: JonesTC,MohrU,HuntRD (eds) Monographs on pathology of laboratory animals. Respiratory system. Springer, Berlin Heidelberg New York, pp 107–111

    Google Scholar 

  • Kauffman SL, Alexander L, Sass L (1979) Histologic and ultrastructural features of the Clara cell adenoma of the mouse lung. Lab Invest 40:708–716

    PubMed  CAS  Google Scholar 

  • Kennedy AR, McGandy RB, Little JB (1977) Histochemical, light and electron microscopic study of polonium-210 induced peripheral tumors in hamster lungs: evidence implicating the Clara cell as the cell of origin. Eur J Cancer 13:1325–1340

    PubMed  CAS  Google Scholar 

  • Kittel B, Ernst H, Dungworth DL, RittinghausenS,NolteT,KaminoK,StuartB,LakeSG,CardesaA,MorawietzG,MohrU (1993) Morphological comparison between benign keratinizing cystic squamous cell tumours of the lung and squamous lesions of the skin in rats. Exp Toxicol Pathol 45:257–267

    PubMed  CAS  Google Scholar 

  • Kittel B, Dungworth DL, Mohr U (1994) Goblet cell metaplasia in the peripheral lung tissue of rats after chronic exposure to particles. In: MohrU,DungworthDL,MauderlyJL,OberdörsterG (eds) Toxic and carcinogenic effects of solid particles in the respiratory tract.International Life Sciences Institute, Washington DC, pp 545–548

    Google Scholar 

  • Kroes R, Garbis-Berkvens JM, de Vries T, van Nesselrooy HJ (1981) Histopathological profile of a Wistar rat stock including a survey of the literature. J Gerontol 36:259–279

    PubMed  CAS  Google Scholar 

  • Lang PL (1987a) Spontaneous neoplastic lesions in the Crl:CD BR rat.Technical publication. Charles River Laboratories, Wilmington, pp 1–13

    Google Scholar 

  • Lang PL (1987b) Spontaneous neoplastic lesions in the Crl:CD-l (ICR)BR mouse. Technical publication. Charles River Laboratories,Wilmington, pp 1–13

    Google Scholar 

  • Lijinsky W, Reuber MD (1988) Neoplasms of the skin and other organs observed in Swiss mice treated with nitrosoalkylureas. J Cancer Res Clin Oncol 114:245–249

    Article  PubMed  CAS  Google Scholar 

  • Löhrke H, Hesse B, Goerttler K (1982) Spontaneous tumours in male and female specified pathogen-free Sprague-Dawley rats (outbred stock SutSDT). Z Versuchstierkd 24:225–230

    PubMed  Google Scholar 

  • Maeda T, Izumi K, Otsuka H, ManabeY,KinouchiT,OhnishiY (1986) Induction of squamous cell carcinoma in the rat lung by 1,6-dinitropyrene. J Natl Cancer Inst 76:693–701

    PubMed  CAS  Google Scholar 

  • Maekawa A, Kurokawa Y, Takahashi M, Kokubo T, Ogiu T, Onodera H, Tanigawa H, Ohno Y, Furukawa F, Hayashi Y (1983a) Spontaneous tumors in F-344/DuCrj rats. Gann 74:365–372

    CAS  Google Scholar 

  • Maekawa A, Onodera H, Tanigawa H, Furuta K, Kodama T, Horiuchi S, HayashiY (1983b) Neoplastic and non-neoplastic lesions in aging Sic:Wistar rats. J Toxicol Sci 8:279–290

    CAS  Google Scholar 

  • Maita K, Hirano M, Harada T, Mitsumori K, Yoshida A, Takahashi K, NakashimaN,KitazawaT,EnomotoA,IniuK,ShirasuY (1988) Mortality, major cause of moribundity, and spontaneous tumors in CD-I mice. Toxicol Pathol 16:340–349

    Article  PubMed  CAS  Google Scholar 

  • McDowell EM (1987) Bronchogenic carcinomas. In: McDowellEM (ed) Lung carcinomas. Churchill Livingstone, Edinburgh, pp 255–285

    Google Scholar 

  • McDowell EM, Trump BF (1983) Histogenesis of preneoplastic and neoplastic lesions in tracheobronchial epi¬thelium. Surv Synth Path Res 2:235–279

    Google Scholar 

  • McDowell EM, Keenan KP, Huang M (1984) Effects of vitamin A-deprivation on hamster tracheal epithelium. A quantitative morphologic study. Virchows Arch B Cell Pathol 45:197–219U (1982) Tumours of the respiratory tract. In: Turusov VS, Delia Porta G, Hollander CF, Mohr U, Shabad LM, Sobin LH, Stanton MF (eds) Pathology of tumours in laboratory animals, vol III: tumours of the hamster. IARC Sci Pubi 34:115–130

    Article  CAS  Google Scholar 

  • Mohr U, Ketkar M (1980) Animal model of human disease: Bronchogenic spontaneous carcinoma of the lung. Am J Pathol 99:521–524

    PubMed  CAS  Google Scholar 

  • Mohr U, Dungworth DL (1988) Relevance to humans of experimentally induced pulmonary tumors in rats and hamsters. In: MohrU, DungworthDL,KimmerleG,LewkowskyJ,McClellanR,StöberW (eds) Inhalation toxicology: the design and interpretation of inhalation studies and their use in risk assessment. Springer, Berlin Heidelberg New York, pp 209–232

    Google Scholar 

  • Mohr U, Bader R, Ernst H, EttlinRA,GembardtC,HarlemanJH,HartigF,JahnW, KalinerG,KarbeE,KaufmannW,KriegK,KrinkeG, KuttlerK,LandesC,MettlerF,MorawietzG,NotmanJ,PuschnerH,QureshiS,ReznikG,RittinghausenS,TuchK,UrwylerH,WeisseG,Weisse I,ZehnderJ (1990a) Tumor Registry Data Base: suggestions for a systematized nomenclature of pre-neoplastic and neoplastic lesions in rats.Exp Pathol 38:1–18

    CAS  Google Scholar 

  • Mohr U, Rittinghausen S, Takenaka S, Ernst H, Dungworth DL, Pylev LN (1990b) Pathology of tumours in laboratory animals. Tumours of the lower respiratory tract and pleura in the rat. In: TurusovVS,MohrU(eds) Pathology of tumours in laborat ory animals, vol I: tumours of the rat, 2nd edn. IARC Sci Pubi 99:275–299

    Google Scholar 

  • Mohr U, Emura M, Dungworth DL, Ernst H (1995) Tumours of the lower respiratory tract. In: MohrU (ed) Pathology of tumours in laboratory animals. III. Tumours of the hamster. IARC Sci Pubi (in press)

    Google Scholar 

  • Morawietz G, Rittinghausen S, Mohr U (1990) Tumor registry data base: advantages using a systematized nomenclature. Schweiz Arch Tierheilkd 132:448–449

    Google Scholar 

  • Morawietz G, Rittinghausen S, Mohr U (1992) RITA-Registry of Industrial Toxicology Animal-Data progress of the working group. Exp Toxicol Pathol 44:301–309

    PubMed  CAS  Google Scholar 

  • Morii S, Fujii T (1973) Spontaneous tumors in Sprague-Dawley JCL rats (authors’ translation). Jikken Dobutsu (Jpn) 22:127–138

    CAS  Google Scholar 

  • Moulton JE (1978) Tumors of the respiratory system. In: MoultonJE (ed) Tumors in domestic animals, 2nd edn. University of California Press,Berkeley, Los Angeles, pp 205–239

    Google Scholar 

  • Muraoka Y, Itoh M, Yamashita F, HayashiY (1977) Spontaneous tumors in aged SD-JCL rats. Jikken Dobutsu (Jpn) 26:13–22

    CAS  Google Scholar 

  • Nolte T (1991) Histogenese und Validierung von Plattenepitheltumoren der Lunge nach Partikel- und Karzinogenexposition bei der Ratte. Medical veterinary dissertation, Tierärztliche Hochschule Hannover

    Google Scholar 

  • Nolte T, Thiedemann KU, Dungworth DL, Ernst H, Paulini I, Heinrich U, DasenbrockC,PetersL,ÃœberschärS,MohrU (1993) Morphology and histogenesis of squamous cell metaplasia of the rat lung after chronic exposure to a pyrolized pitch condensate and/or carbon black, or to combinations of pyrolized pitch condensate, carbon black and irritant gases. Exp Toxicol Pathol 45:135–144

    PubMed  CAS  Google Scholar 

  • Nolte T, Thiedemann KU, Dungworth DL, Ernst H, Paulini I, Heinrich U, DasenbrockC,PetersL,ÃœberschärS,MohrU (1993) Morphology and histogenesis of squamous cell metaplasia of the rat lung after chronic exposure to a pyrolized pitch condensate and/or carbon black, or to combinations of pyrolized pitch condensate, carbon black and irritant gases. Exp Toxicol Pathol 45:135–144

    PubMed  CAS  Google Scholar 

  • Ohshima M, Ward JM, Singh G, KatyalSL (1985) Immunocytochemical and morphological evidence for the origin of N-nitrosomethylurea-induced and naturally occurring primary lung tumors in F344/NCr rats. Cancer Res 45:2785–2792

    PubMed  CAS  Google Scholar 

  • Palmer KC (1985) Clara cell adenomas of the mouse lung. Interaction with alveolar type 2 cells. Am J Pathol 120:455–463

    PubMed  CAS  Google Scholar 

  • Pour PM (1983) Spontaneous respiratory tract tumors in Syrian hamsters. In: Reznik-SchüllerHM (ed) Comparative respiratory tract carcinogenesis, vol I: spontaneous respiratory tract carcinogenesis. CRC, Boca Raton, pp 131–170

    Google Scholar 

  • Pour PM, Reznik-Schüller HM (1985) Squamous cell carcinoma, lung, Syrian hamster. In: JonesTC,MohrU,HuntRD (eds) Monographs on pathology of laboratory animals. Respiratory system. Springer, Berlin Heidelberg New York, pp 117–123

    Google Scholar 

  • Pour PM, Mohr U, Cardesa A, AlthoffJ,KmochN (1976) Spontaneous tumors and common diseases in two colonies of Syrian hamsters. II. Respiratory tract and digestive system. J Natl Cancer Inst 56:937–948

    PubMed  CAS  Google Scholar 

  • Pour PM, Althoff J, Salmasi SZ, StepanK (1979) Spontaneous tumors and common diseases in three types of hamsters. J Natl Cancer Inst 63:797–811

    PubMed  CAS  Google Scholar 

  • Prejean JD, Peckham JC, Casey AE, Griswold DP, Weisburger EK, Weisburger JH (1973) Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Cancer Res 33:2768–2773

    PubMed  CAS  Google Scholar 

  • Rao GN, Birnbaum LS, Collins JJ, Tennant RW, Skow LC (1988) Mouse strains for chemical carcinogenicity studies: overview of a workshop. Fund Appi Toxicol 10:385–394

    Article  CAS  Google Scholar 

  • Rehm S, Rapp KG, Deerberg F (1985) Influence of food restriction and body fat on life span and tumour incidence in female outbred Han.NMRI mice and two sublines. Z Versuchstierkd 27:249–283

    Google Scholar 

  • Rehm S, Ward JM, ten Have-Opbroek AAW, Anderson LM, Singh G, Katyal SL, Rice JM (1988) Mouse papillary lung tumors transplacentally induced by N-nitrosoethylurea: evidence for alveolar type II cell origin by comparative light microscopic, ultrastructural, and immunohistochemical studies. Cancer Res 48:148–160

    PubMed  CAS  Google Scholar 

  • Rehm S, Takahashi M, Ward JM, Singh G, Katyal SL, Henneman JR (1989) Immunohistochemical demonstration of Clara cell antigen in lung tumors of bronchiolar origin induced by N-nitrosodiethylamine in Syrian golden hamsters. Am J Pathol 134:79–87

    PubMed  CAS  Google Scholar 

  • Rehm S, Devor DE, Henneman JR, WardJM (1991a) Origin of spontaneous and transplacentally induced mouse lung tumors from alveolar type II cells. Exp Lung Res 17:181–195

    Article  CAS  Google Scholar 

  • Rehm S, Lijinsky W, Singh G, KatyalSL (1991b) Mouse bronchiolar cell carcinogenesis. Histologic characterization and expression of Clara cell antigen in lesions induced by N-nitrosobis-(2-chloroethyl) ureas. Am J Pathol 139:413–422

    CAS  Google Scholar 

  • Rehm S, Lijinsky W, Thomas RG, Kasprzak BH (1993) Clara cell antigen in normal and migratory dysplastic Clara cells, and bronchioloalveolar carcinoma of Syrian hamsters induced by N-nitrosomethyl-n-heptylamine. Virchows Arch B Cell Pathol 64:181–190

    Article  CAS  Google Scholar 

  • Rehm S, Ward JM, Sass B (1994) Tumours of the lungs. In: MohrU,TurusovVS (eds) Pathology of tumours in laboratory animals, vol II: tumours of the mouse, 2nd edn. IARC Sci Pubi 111:325–355

    Google Scholar 

  • Reznik G (1981) Unusual sites of lung tumor metastases in B6C3FX mice and F344 rats. Anticancer Res 1:159–162

    PubMed  CAS  Google Scholar 

  • Reznik G (1983) Spontaneous primary and secondary lung tumors in the rat. In: Reznik-SchüllerHM (ed) Comparative respiratory tract carcinogenesis, vol 1: spontaneous respiratory tract carcinogenesis. CRC, Boca Raton, pp 95–116

    Google Scholar 

  • Reznik-Schüller HM (1976) Ultrastructural alterations of nonciliated cells after nitrosamine treatment and their significance for pulmonary carcinogenesis. Am J Pathol 85:549–554

    PubMed  Google Scholar 

  • Reznik-Schüller HM (1977a) Sequential morphologic alterations in the bronchial epithelium of Syrian golden hams¬ters during N-nitrosomorpholine-induced pulmonary tumorigenesis. Am J Pathol 89: 59–66

    Google Scholar 

  • Reznik-Schüller HM (1977b) Ultrastructural alterations of APUD cells during nitrosamine-induced lung carcinogenesis. J Pathol 121:79–82

    Article  Google Scholar 

  • Reznik-Schüller HM, GreggM (1981) Pathogenesis of lung tumors induced by N-nitrosoheptamethylene-imine in F344 rats. Virchows Arch A Pathol Anat Histopathol 393:333–343

    Article  Google Scholar 

  • Reznik-Schüller HM, ReznikG (1982) Morphology of spontaneous and induced tumors in the bronchioloalveolar region of F344 rats. Anticancer Res 2:53–57

    PubMed  Google Scholar 

  • Reznik-Schüller HM, HaguePH,CreasiaDA (1981) Ultrastructure of pulmonary tumors induced in rats by N-nitrosomethylurethane. J Toxicol Environ Health 8:501–506

    Article  PubMed  Google Scholar 

  • Rittinghausen S, Dungworth DL, Ernst H, Mohr U (1992) Primary pulmonary tumors. In: MohrU,DungworthDL,CapenCC (eds) Pathobiology of the aging rat, vol 1. International Life Sciences Institute, Washington DC, pp 161–172

    Google Scholar 

  • Sass B, Liebelt AG (1985) Metastatic tumors, lung, mouse. In: JonesTC,MohrU,HuntRD (eds) Monographs on pathology of laboratory animals. Respiratory system. Springer, Berlin Heidelberg New York, pp 138–159

    Google Scholar 

  • Sato T, Kauffman SL (1980) A scanning electron microscopic study of the Type II and Clara cell adenoma of the mouse lung. Lab Invest 43:28–36

    PubMed  CAS  Google Scholar 

  • Schüller HM (1987) Experimental carcinogenesis in the peripheral lung. In: McDowellEM (ed) Lung carcinomas. Churchill Livingstone, Edinburgh, pp 243–254

    Google Scholar 

  • Schüller HM, McMahon JB (1985) Inhibition of N-nitrosodiethylamine-induced respiratory tract carcinogenesis by piperonylbutoxide in hamsters. Cancer Res 45:2807–2812

    PubMed  Google Scholar 

  • Schüller HM, Becker KL, Witschi HP (1988) An animal model for neuroendocrine lung cancer. Carcinogenesis 9:293–296

    Article  PubMed  Google Scholar 

  • Schüller HM, Witschi HP, Nylen E, Joshi PA, Correa E, Becker KL (1990) Pathobiology of lung tumors induced in hamsters by 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone and the modulating effect of hyperoxia. Cancer Res 50:1960–1965

    PubMed  Google Scholar 

  • Schwartz LW, Hahn FF, Keenan KP, Keenan CM, Brown HR, Mann PC (1991) Proliferative lesions of the rat respiratory tract, R-l. Guides for toxicologic pathology. STP/ARP/ AFIP, Washington DC, pp 1–26

    Google Scholar 

  • Sheldon WG, Greenman DL (1979) Spontaneous lesions in control BALB/c female mice. J Exp Pathol Toxicol 3:155–167

    Google Scholar 

  • Sher SP, Jensen RD, Bokelman DL (1982) Spontaneous tumors in control F344 and Charles River-CD rats and Charles River CD-I and B6C3HF1 mice. Toxicol Lett 11:103–110

    Article  PubMed  CAS  Google Scholar 

  • Smith GS, Walford RL, Mickey MR (1973) Lifespan and incidence of cancer and other diseases in selected long-lived inbred mice and their F1 hybrids. J Natl Cancer Inst 50:1195–1213

    PubMed  CAS  Google Scholar 

  • Solleveld HA, Haseman JK, McConnell EE (1984) Natural history of body weight gain, survival, and neoplasia in the F344 rat. J Natl Cancer Inst 72:929–940

    PubMed  CAS  Google Scholar 

  • Stewart HL, Dunn TB, Snell KC, DeringerMK (1979) Tumours of the respiratory tract. In: TurusovVS,Della PortaG, HollanderCF,MohrU,ShabadLM,SobinLH,StantonMF (eds) Pathology of tumors in laboratory animals, vol II: tumors of the mouse. IARC Sci Pubi 23:251–287

    Google Scholar 

  • Stoner GD, Shimkin MB (1982) Strain A mouse lung tumor bioassay. J Am Coll Toxicol 1:145–169

    CAS  Google Scholar 

  • Stula EF (1975)Naturally occurring pulmonary tumors of epithelial origin in Charles River-CD rats. Bull Soc Pharmacol Environ Pathol 3:3–11

    Google Scholar 

  • Takaki Y, Kitamura S, Uekusa T, Honma S, Aze Y, Wakabayashi K, Kuwabara N, Fukuda Y (1989) Spontaneous tumors in F-344/Jcl rats. J Toxicol Sci 14:181–195

    PubMed  CAS  Google Scholar 

  • Tamaño S, Hagiwara A, Shibata MA, Kurata Y, Fukushima S, Ito N (1988) Spontaneous tumors in aging (C57BL/6N X C3H/HeN)F1 (B6C3F1) mice. Toxicol Pathol 16:321–326

    Article  PubMed  Google Scholar 

  • Thaete LG, Malkinson AM (1990) Differential staining of normal and neoplastic mouse lung epithelia by succinate dehydrogenase histochemistry. Cancer Lett 52:219–227

    Google Scholar 

  • Thaete LG, Malkinson AM (1991) Cells of origin of primary pulmonary neoplasms in mice: morphologic and histochemical studies. Exp Lung Res 17:219–228

    Article  PubMed  CAS  Google Scholar 

  • Thaete LG, Gunning WT, Stoner GD, Malkinson AM (1987) Cellular derivation of lung tumors in sensitive and resistant strains of mice: results at 28 and 56 weeks after urethan treatment. J Natl Cancer Inst 78:743–749

    PubMed  CAS  Google Scholar 

  • Thaete LG, Nesbitt MN, Malkinson AM (1991) Lung adenoma structure among inbred strains of mice: the pulmonary adenoma histologic type (Pah) genes. Cancer Lett 61:15–20

    Article  PubMed  CAS  Google Scholar 

  • Toth B, Shimizu H (1974) 1-Carbamyl- 2-phenylhydrazine tumorigenesis in Swiss mice. Morphology of lung adenomas. J Natl Cancer Inst 52:241–251

    PubMed  CAS  Google Scholar 

  • Turusov VS, Breslow NE, Tomatis L (1974) Frequency and organ distribution of lung tumor metastases in CF-1 mice. J Natl Cancer Inst 52:225–232

    PubMed  CAS  Google Scholar 

  • Ueberberg H, Lützen L (1979) The spontaneous rate of tumours in the laboratory rat: strain Chbb:THOM(SPF). Arzneimittelforschung 29:1876–1879

    PubMed  CAS  Google Scholar 

  • Ward JM, Rehm S (1990) Applications of immunohistochemistry in rodent tumor pathology. Exp Pathol 40:301–31

    PubMed  CAS  Google Scholar 

  • Ward JM, Goodman DG, Squire RA, Chu KC, Linhart MS (1979) Neoplastic and nonneoplastic lesions in aging (C57BL/6N X C3H/HeN)F1(B6C3F1) mice. J Natl Cancer Inst 63: 849–854

    PubMed  CAS  Google Scholar 

  • Ward JM, Hamlin MH II, Ackerman LJ, Lattuada CP, Longfellow DG, Cameron TP (1983) Age-related neoplastic and degenerative lesions in aging male virgin and ex-breeder ACI/segHapBR rats. J Gerontol 38:538–548

    PubMed  CAS  Google Scholar 

  • Ward JM, Singh G, Katyal SL, AndersonLM,KovatchRM (1985) Immunocytochemical localization of the surfactant apoprotein and Clara cell antigen in chemically induced and naturally occuring pulmonary neoplasms of mice. Am J Pathol118:493–499

    PubMed  CAS  Google Scholar 

  • Witschi H, Schüller HM (1991) Diffuse and continuous cell proliferation enhances radiation-induced tumorigenesis in hamster lung. Cancer Lett 60:193–197

    Article  PubMed  CAS  Google Scholar 

  • Yang YH, Grice HC (1965) Mucinous bronchiolar carcinoma of the rat lung - a case report. J Comp Med Vet Sci 29:15–17

    CAS  Google Scholar 

Download references

Authors
  1. S. Rittinghausen
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Donald L. Dungworth
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Heinrich Ernst
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ulrich Mohr
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. ILSI Research Foundation, Harvard Medical School, 1126 Sixteenth Street,N.W., Washington, DC, 20036, USA

    Thomas Caryle Jones D.V.M., D.Sc. (Professor of Comparative Pathology Emeritus) (Professor of Comparative Pathology Emeritus)

  2. University of California, Davis, 6260 Cape George Road, Port Townsend, WA, 98368, USA

    Donald L. Dungworth B.V.Sc, Ph.D., M.R.C.V.S. (Professor of Veterinary Pathology, Emeritus) (Professor of Veterinary Pathology, Emeritus)

  3. Medizinische Hochschule Hannover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, 30625, Hannover, Germany

    Ulrich Mohr MD (Professor of Experimental Pathology) (Professor of Experimental Pathology)

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Rittinghausen, S., Dungworth, D.L., Ernst, H., Mohr, U. (1996). Naturally Occurring Pulmonary Tumors in Rodents. In: Jones, T.C., Dungworth, D.L., Mohr, U. (eds) Respiratory System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61042-4_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-61042-4_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64667-6

  • Online ISBN: 978-3-642-61042-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation