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Molecular Genetics of the Renin Angiotensin Aldosterone System in Human Hypertension

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Genetic Approaches to Noncommunicable Diseases

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Abstract

Blood pressure is a quantitative trait that varies continuously throughout the whole population and whose regulation is controlled by a variety of mechanisms that involve several genetic loci and environmental factors. However, little is known about the genes actually involved in human hypertension, about their respective importance in determining blood pressure level, and their interaction with other genes and environmental components. A number of epidemiologic studies have shown that individual blood pressure levels result from both genetic predisposition and environmental factors. The heritable component of blood pressure has been documented in familial and twin studies. The evidence suggests that approximately 30% of the variance of blood pressure is attributable to genetic heritability and 50% to environmental influences (Ward 1990).

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Authors
  1. P. Corvol
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  2. F. Soubrier
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  3. X. Jeunemaitre
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Editors and Affiliations

  1. Institute of Medical Genetics, University of Oslo, P.O. Box 1036, Blindern, 0315, Oslo, Norway

    Kare Berg Prof., Dr.

  2. Human Genetics Programme, World Health Organization, 1211, Geneva 27, Switzerland

    Victor Boulyjenkov Dr.

  3. Fondation IPSEN, 24, rue Erlanger, 75781, Paris, France

    Yves Christen Dr.

  4. Department of Medical Genetics, Ulleval University Hospital, P.O. Box 1036, Blindern, 0315, Oslo, Norway

    Kare Berg Prof., Dr.

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© 1996 Springer-Verlag Berlin Heidelberg

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Corvol, P., Soubrier, F., Jeunemaitre, X. (1996). Molecular Genetics of the Renin Angiotensin Aldosterone System in Human Hypertension. In: Berg, K., Boulyjenkov, V., Christen, Y. (eds) Genetic Approaches to Noncommunicable Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61028-8_6

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  • DOI: https://doi.org/10.1007/978-3-642-61028-8_6

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