Skip to main content
SpringerLink
Log in

Medikamentöse Therapie der Colitis ulcerosa

  • Chapter
Morbus Crohn - Colitis ulcerosa

  • 116 Accesses

Zusammenfassung

Die Colitis ulcerosa ist durch keine konservative Maßnahme zu heilen. Die medikamentöse Therapie hat das Ziel, durch Verringerung der Entzündungsaktivität die Symptomatik zu verbessern, die Lebensqualität des Patienten zu steigern und das Auftreten von Rezidiven zu verhindern. Die Wahl der Therapie muß sich dabei an der Krankheitsaktivität und dem Vorhandensein von Komplikationen orientieren. Darüber hinaus wird die therapeutische Strategie von der Lokalisation und der Ausdehnung der Entzündung beeinflußt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 64.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

Therapie der akuten Colitis ulcerosa mit Glukokortikoiden

  • Bianchi Porro G, Prantera C, Campieri M et al. (1994) Comparative trial of methylprednisolone and budesonide enemas in active distal ulcerative systemic effects for the treatment of distal ulcerative Colitis or proctitis. Scand J Gastroenterol 27: 9–12

    Google Scholar 

  • The Danish Budesonide Study group (1991) Budesonide enema in distal ulcerative Colitis. A randomized dose-response trial with Prednisolon enema as positive control. Scand J Colitis. Eur J Gastroenterol Hepatol 6: 125–130

    Article  Google Scholar 

  • Danielsson A, Löfberg R, Persson T et al. (1992) A Steroid enema, budesonide, lacking Gastroenterol 26: 1225–1230

    Google Scholar 

  • Järnerot G, Rolny P, Sandberg-Gertzén H (1985) Intensive intravenous treatment of ulcerative Colitis. Gastreoenterology 89: 1005–1013

    Google Scholar 

  • Nyman-Pantelidis M, Nilsson A, G-Wagner Z et al. (1994) Pharmacokinetics and retrograde colonic spread of budesonide enemas in patients with distal ulcerative Colitis. Aliment Pharmacol Ther 8: 617–622

    Article  PubMed  CAS  Google Scholar 

  • Truelove SC, Witts LJ (1955) Cortisone in ulcerative Colitis. Final report on a therapeutic trial. Br Med J 2: 1041–1048

    CAS  Google Scholar 

Sulfasalazin zur Behandlung der akuten Colitis ulcerosa

  • Baron JH, Connell PM, Lennard-Jones JE et al. (1962) Sulphasalazine and salicylazosulphadimidine in ulcerative Colitis. Lancet 1: 1094–1096

    Article  PubMed  CAS  Google Scholar 

  • Dick AP, Grayson MJ, Carpenter RG et al. (1964) Controlled trial of sulphasalazine in the treatment of ulcerative colititis. Gut 5: 437–442

    Article  PubMed  CAS  Google Scholar 

  • Margolin ML, Krumholz MP, Fochios SE et al. (1988) Clinical trials in ulcerative Colitis. II. Historical review. Am J Gastroenterol 83: 227–243

    PubMed  CAS  Google Scholar 

Aminosalizylate zur Behandlung der akuten Colitis ulcerosa

  • Campieri M, Franchis R de, Bianchi Porro G et al. (1990) Mesalazine (5-aminosalicylic acid) suppositories in the treatment of ulcerative procitis or distal proctosigmoiditis. Scand J Gastroenterol 25: 663–668

    Article  PubMed  CAS  Google Scholar 

  • Campieri M, Gionchetti P, Belluzzi A et al. (1991) Optimum dosage of 5-aminosalicylic acid as rectal enemas in patients with active ulcerative Colitis. Gut 31: 929–931

    Article  Google Scholar 

  • Campieri M, Paoluzi P, D’Albasio G et al. (1993) Better quality of therapy with 5-ASA colonic foam in active ulcerative Colitis. Dig Dis Sei 38: 1843–1850

    Article  CAS  Google Scholar 

  • Danish 5-ASA Group (1987) Topical 5-aminosalicylic acid versus prednisolone in ulcerative proctosigmoiditis. Dig Dis Sei 32: 598–602

    Article  Google Scholar 

  • Hanauer S, Schwartz J, Robinson M et al. (1993) Mesalamine capsules for treatment of active ulcerative Colitis: results of a controlled trial. Am J Gastroenterol 88: 1188–1197

    PubMed  CAS  Google Scholar 

  • Marshall JK, Irvine EJ (1995) Rectal aminosalicylate therapy for distal ulcerative Colitis: a meta-analysis. Aliment Pharmacal Ther 9: 293–300

    Article  CAS  Google Scholar 

  • O’Donnell LJD, Arvind AS, Hoang P et al. (1992) Double blind, controlled trial of 4-aminosalicylic acid and prednisolone enemas in distal ulcerative Colitis. Gut 33: 947–949

    Article  PubMed  Google Scholar 

  • Porro G, Ardizzone S, Petrillo M et al. (1995) Low dosage versus hydrocortisone in the topical treatment of active ulcerative Colitis: a randomized, double-blind study. Am J Gastroenterol 90: 736–739

    Google Scholar 

  • Rachmilewitz D (1989) Coated mesalazine (5-aminosalicylic acid) versus sulphasalazine in the treatment of active ulcerative Colitis: a randomised trial. Br Med J 298: 82–86

    Article  CAS  Google Scholar 

  • Robinson M, Hanauer S, Hoop R et al. (1994) Mesalamine capsules enhance the quality of life for patients with ulcerative Colitis. Aliment Pharmacol Ther 8: 27–34

    Article  PubMed  CAS  Google Scholar 

  • Sninsky CA, Cort DH, Shanahan F (1991) Oral mesalamine (Asacol) for mildly to moderately active ulcerative Colitis. Ann Intern Med 115: 350–355

    PubMed  CAS  Google Scholar 

  • Sutherland LR, Martin F, Greer S et al. (1987) 5-aminosalicylic acid enema in the treatment of distal ulcerative Colitis, proctosigmoiditis, and proctitis. Gastroenterology 92: 1894–1898

    PubMed  CAS  Google Scholar 

  • Sutherland LR, May GR, Shaffer EA (1993) Sulfasalazine revisited: a meta-analysis of 5-aminosalicylic acid in the treatment of ulcerative Colitis. Ann Intern Med 118: 540–549

    PubMed  CAS  Google Scholar 

Enterale und parenterale Ernährung

  • Järnerot G, Rolny P, Sandberg-Gertzén H (1985) Intensive intravenous treatment of ulcerative Colitis. Gastroenterology 89: 1005–1013

    PubMed  Google Scholar 

Nichtsteroidale Immunsuppressiva zur Behandlung der akuten Colitis ulcerosa

  • Adler D, Korelitz BI (1990) The therapeutic efficacy of 6-mercaptopurine in refractory ulcerative Colitis. Am J Gastroenterol 85: 717–722

    PubMed  CAS  Google Scholar 

  • Lobo AJ, Foster PN, Burke DA et al. (1990) The role of azathioprine in the management of ulcerative Colitis. Dis Colon Rectum 33: 374–377

    Article  PubMed  CAS  Google Scholar 

Antibiotika

  • Chapman RW, Selby WS, Jewell DP (1986) Controlled trial of intravenous metronidazole as an adjunct to corticosteroids in severe ulcerative Colitis. Gut 27: 1210–1212

    Article  PubMed  CAS  Google Scholar 

Cyclosporin

  • Lichtiger S, Present DH, Kornbluth A et al. (1994) Cyclosporine in severe ulcerative Colitis refractory to Steroid therapy. N Engl J Med 330: 1841–1845

    Article  PubMed  CAS  Google Scholar 

  • Sandborn WJ, Tremaine WJ, Schroeder KW et al. (1994) A placebo-controlled trial of cyclosporine enemas for mildly to moderately active left-sided ulcerative Colitis. Gastroenterology 106: 1429–1435

    PubMed  CAS  Google Scholar 

Neue Therapieansätze

  • Aslan A, Triadafilopoulos G (1992) Fish oil fatty acid supplementation in active ulcerative Colitis: a double-blind, placebo-controlled, crossover study. Am J Gastroenterol 87:432–437

    PubMed  CAS  Google Scholar 

  • Collawn C, Rubin P, Perez N et al. (1992) Phase II study of the safety and efficacy of a 5- lipoxygenase inhibitor in patients with ulcerative Colitis. Am J Gastroenterol 87: 342–346

    PubMed  CAS  Google Scholar 

  • Gaffney PR, Doyle CT, Gaffney A et al. (1995) Paradoxical response to heparin in 10 patients with ulcerative Colitis. Am J Gastroenterol 90: 220–223

    PubMed  CAS  Google Scholar 

  • Hawthorne AB, Daneshmend TK, Hawkey CJ et al. (1992) Treatment of ulcerative Colitis with fish oil supplementation: a prospective 12 month randomised controlled trial. Gut 33: 922–928

    Article  PubMed  CAS  Google Scholar 

  • Jarlov AE, Munkholm P, Nordblad-Schmidt P et al. (1993) Treatment of active distal ulcerative Colitis with immunoglobulin G enemas. Aliment Pharmacol Ther 7: 561–565

    Article  PubMed  CAS  Google Scholar 

  • Laursen LS, Lauritsen K, Bukhave K et al. (1994) Selective 5-lipoxygenase inhibition by zileuton in the treatment of relapsing ulcerative Colitis: a randomized double-blind placebocontrolled multicentre trial. Eur J Gastroenterol Hepatol 6: 209–215

    Article  Google Scholar 

  • Lorenz R, Heinmüller M, Classen M et al. (1991) Substitution of Factor XIII: a therapeutic approach to ulcerative Colitis. Haemostasis 21: 5–9

    PubMed  CAS  Google Scholar 

  • Pullan RD, Thodes J, Ganesh S et al. (1994) Transdermal nicotine for active ulcerative Colitis. N Engl J Med 330: 811–815

    Article  PubMed  CAS  Google Scholar 

  • Scheppach W, Sommer H, Kirchner T et al. (1992) Effect of butyrate enemas on the colonic mucosa in distal ulcerative Colitis. Gastroenterology 103: 51–56

    PubMed  CAS  Google Scholar 

  • Staerk Laursen L, Naesdal J, Bukhave K et al. (1990) Selective 5-lipoxygenase inhibition in ulcerative Colitis. Lancet 335: 683–685

    Article  Google Scholar 

  • Steinhart AH, Brzezinski A, Baker JP (1994) Treatment of refractory ulcerative proctosigmoiditis with butyrate enemas. Am J Gastroenterol 89: 179–183

    PubMed  CAS  Google Scholar 

  • Stenson WF, Cort D, Rodgers J et al. (1992) Dietary supplementation with fish oil in ulcerative Colitis. Ann Intern Med 116: 609–614

    PubMed  CAS  Google Scholar 

  • Thomas GAO, Rhodes J, Mani V et al. (1995) Transdermal nicotine as maintenance therapy for ulcerative Colitis. N Engl J Med 332: 988–992

    Article  PubMed  CAS  Google Scholar 

  • Vernia P, Cittadini M, Caprilli R et al. (1995) Topical treatment of refractory distal ulcerative Colitis with 5-ASA and sodium butyrate. Dig Dis Sei 40: 305–307

    Article  CAS  Google Scholar 

Therapie zur Remissionserhaltung der Colitis ulcerosa

  • Courtney MG, Nunes DP, Bergin CF et al. (1992) Randomised comparison of olsalazine and mesalazine in prevention of relapses in ulcerative Colitis. Lancet 339: 1279–1281

    Article  PubMed  CAS  Google Scholar 

  • Franchis R de, Vecchi M, Carpinelli L et al. (1993) Comparison of the efficacy and safety of sulphasalazine and mesalazines in the maintenance treatment of ulcerative Colitis; a metaanalysis. Eur J Gastroenterol Hepatol 5: 505–510

    Google Scholar 

  • Kruis W, Judmaier G, Kayasseh L et al. (1995) Double-blind dose-finding study of olsalazine versus sulphalazine as maintenance therapy for ulcerative Colitis. Eur J Gastroenterol Hepatol 7: 391–396

    PubMed  CAS  Google Scholar 

  • Miner PB, Biddle WL (1990) Maintaining remission in distal ulcerative Colitis and ulcerative Colitis. Can J Gastroenterol 4: 476

    Google Scholar 

  • Miner P, Hanauer S, Robinson M et al. (1995) Safety and efficacy of controlled-release mesalamine for maintenance of remission in ulcerative Colitis. Dig Dis Sei 40: 296–304

    Article  CAS  Google Scholar 

  • Sachar DB (1995) Maintenance therapy in ulcerative Colitis and Crohn’s disease. J Clin Gastroenterol 20: 117–122

    Article  PubMed  CAS  Google Scholar 

  • Wright JP, O’Keefe EA, Cuming L et al. (1993) Olsalazine in maintenance of clinical remission in patients with ulcerative Colitis. Dig Dis Sei 38: 1837–1842

    Article  CAS  Google Scholar 

Therapieempfehlungen

  • Bitton A, Peppercorn MA (1995) Medical therapy of ulcerative proctitis and proctosigmoiditis, including refractory disease. Inflamm Bow Dis 1: 207–219

    Article  Google Scholar 

  • Ferzoco SJ, Becker JM (1994) Does aggressive medical therapy for acute ulcerative Colitis result in a higher incidence of staged colectomy? Arch Surg 129: 420–424

    PubMed  CAS  Google Scholar 

  • Hanauer SB, Baert FJ (1995) The management of ulcerative Colitis. Annu Rev Med 46: 497–505

    Article  PubMed  CAS  Google Scholar 

  • Järnerot G, Rolny P, Sandberg-Gertzen H (1985) intensive intravenous treatment of ulcerative Colitis. Gastroenterology 89: 1005–1013

    PubMed  Google Scholar 

  • Kornbluth AA, Salomon P, Sacks HS et al. (1993) Meta-analysis of the effectiveness of current drug therapy of ulcerative Colitis. J Clin Gastroenterol 16: 215–218

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Medizinische Klinik und Poliklinik, Universität Ulm, Robert-Koch-Str. 8, 89081, Ulm, Germany

    Prof. Dr. Guido Adler

Authors
  1. Prof. Dr. Guido Adler
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Adler, G. (1996). Medikamentöse Therapie der Colitis ulcerosa. In: Morbus Crohn - Colitis ulcerosa. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61023-3_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-61023-3_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64661-4

  • Online ISBN: 978-3-642-61023-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation