Skip to main content
SpringerLink
Log in

Prädiktion des Therapieerfolges bei psychiatrischen Erkrankungen: Ein Beitrag zu Konzept und Methodik psychiatrischer Prädiktorforschung

  • Conference paper
Therapie im Grenzgebiet von Psychiatrie und Neurologie

  • 27 Accesses

Zusammenfassung

Die Prognostik psychiatrischer Erkrankungen ist von vergleichbarer klinischer Bedeutung wie Diagnostik und Therapie: Nur in Kenntnis der spontanen Verlaufsprognose einer Erkrankung und deren zu erwartender Verbesserung durch ein geeignetes Therapieverfahren läßt sich die Indikation zu dessen Anwendung- und damit die Inkaufnahme etwaiger unerwünschter Begleitwirkungen - begründen. Verständlicherweise hat mit der Entwicklung hochwirksamer psychiatrischer Therapieverfahren das Interesse an der „Prädiktion“ des Behandlungserfolgs, also eines unter Nutzen/Risiko- wie Kostenaspekt begründeten Einsatzes eines Therapieverfahrens, zugenommen. Dennoch ist das gesicherte Wissen zur Prädiktion des Behandlungserfolgs in der Psychiatrie unbefriedigend. Dies liegt nicht zuletzt an unbewältigten konzeptuellen und methodischen Problemen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Alpert M (1985) The signs and symptoms of schizophrenia. Compr Psychiatry 26: 103–112

    Article  PubMed  CAS  Google Scholar 

  • American Psychiatric Association (APA) (1994) DSM-IV (Diagnostic and Statistical Manual of Mental Disorders), 4th edn. APA, Washington DC

    Google Scholar 

  • Awad AG (1989) Drug therapy in schizophrenia: variability of outcome and prediction response. Can J Psychiatry 34: 711–720

    PubMed  CAS  Google Scholar 

  • Awad A (1992) Quality of life of schizophrenic patients on medications and implications for new drug trials. Hosp Commun Psychiatry 43: 262–265

    CAS  Google Scholar 

  • Awad AG (1994) Prediction research of neuroleptic treatment outcome in schizophrenie-state of the art: 1978–1993. In: Gaebel W, Awad AG (eds) Prediction of neuroleptic treatment outcome in schizophrenia. Concepts and methods. Springer, Wien, pp 1–14

    Google Scholar 

  • Awad AG, Hogan TP (1985) Early treatment events and prediction of response to neuroleptics in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 9: 585–588

    Article  PubMed  CAS  Google Scholar 

  • Bartko G, Herczeg I, Bekesy M (1987) Predicting outcome of neuroleptic treatment on the basis of subjective response and early clinical improvement. J Clin Psychiatry 48: 363–365

    PubMed  CAS  Google Scholar 

  • Bielsky RJ, Friedel RO (1976) Prediction of tricyclic antidepressants response. A critical review. Arch Gen Psychiatry 33: 1479–1489

    Google Scholar 

  • Birnbaum K (1923) Der Aufbau der Psychose. Grundzüge der psychiatrischen Strukturanalyse. Springer, Berlin

    Google Scholar 

  • Carpenter WT, Heinrichs DW, Hanlon TE (1981) Methodologic standards for treatment outcome research in schizophrenia. Am J Psychiatry 138: 465–471

    PubMed  Google Scholar 

  • Clements K, Turpin G (1992) Vulnerability models and schizophrenia: the assessment and prediction of relapse. In: Birchwood M, Tarrier N (eds) Innovations in the psychological management of schizophrenia. Wiley, Chichester New York Brisbane Toronto Singapore, pp 21–47

    Google Scholar 

  • Dewey SL, Smith GS, Logan J et al. (1993) Striatal binding of PET ligand 11C-Raclopride is altered by drugs that modify synaptic dopamine levels. Synapse 13: 350–356

    Article  PubMed  CAS  Google Scholar 

  • Dilling H, Mombour W, Schmidt MH (Hrsg) (1991) Weltgesundheitsorganisation: Internationale Klassifikation psychischer Störungen. Huber, Bern Göttingen Toronto

    Google Scholar 

  • Engel GL (1980) The clinical application of the bio-psychosocial model. Am J Psychiatry 137: 535–544

    PubMed  CAS  Google Scholar 

  • Frank E, Prien RF, Jarrett RB et al. (1991) Conceptualization and rationale for consensus definitions of terms in major depressive disorder. Remission, recovery, relapse, and recurrence. Arch Gen Psychiatry 48: 851–855

    PubMed  CAS  Google Scholar 

  • Freed WJ (1988) The therapeutic latency of neuroleptic drugs and nonspecific postjunctional supersensitivity. Schizophr Bull 14: 269–277

    PubMed  CAS  Google Scholar 

  • Freyhan FA (1957) Psychomotilität, extrapyramidale Syndrome and Wirkungsweisen neuroleptischer Therapien (Chlorpromazin, Reserpin, Prochlorperazin). Der Nervenarzt 28: 504–509

    PubMed  CAS  Google Scholar 

  • Gaebel W (1993) The importance of non-biological factors in influencing the outcome of clinic trials. Br J Psychiatry 163 [Suppl 22]: 44–50

    Google Scholar 

  • Gaebel W, Renfordt E (eds) (1989) Objective methods for behavioral analysis in psychiatry and psychopharmacology-examples and concepts. Pharmacopsychiatry 22 [Suppl]: 1–50

    Google Scholar 

  • Gaebel W, Awad AG (1994) Prediction research in neuroleptic therapy-future directions. In: Gaebel W, Awad AG (eds) Prediction of neuroleptic treatment outcome in schizophrenia. Concepts and methods. Springer, Wien, pp 203–209

    Google Scholar 

  • Gaebel W, Wölwer W (1995) Affektstörungen Schizophrener. Kohlhammer, Stuttgart, in Vorbereitung

    Google Scholar 

  • Gaebel W, Pietzcker A, Baumgartner A (1986) 3-year follow-up of schizophrenic patients-outcome dimensions and neuroleptic treatment. Pharmacopsychiatry 19: 208–209

    Article  Google Scholar 

  • Gaebel W, Pietzcker A, Ulrich G et al. (1988) Predictors of neuroleptic treatment response in acute schizophrenia. Pharmacopsychiatry 21: 384–386

    Article  PubMed  CAS  Google Scholar 

  • Gaebel W, Müller-Oerlinghausen B, Schley J (1992) Early serum levels of neuroleptics do not predict therapeutic response in schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry 16: 891–900

    Article  PubMed  CAS  Google Scholar 

  • Gaebel W, Frick U, Köpcke W et al. (1993) Early neuroleptic intervention in schizophrenia-are prodromal symptoms valid predictors of relapse? Br J Psychiatry 163 [Suppl 21): 8–12

    Google Scholar 

  • Goodman A (1991) Organic unity theory: the mind-body problem revisited. Am J Psychiatry 148: 553–563

    PubMed  CAS  Google Scholar 

  • Heimchen H, Gaebel W (1987) Strategies of clinical research on neurobiological determinants of psychosis. Psychiatr Dev 5: 51–62

    Google Scholar 

  • Hogarty GE, Goldberg SC, Collaborative Study Group (1973) Drug and sociotherapy in the aftercare of schizophrenic patients. Arch Gen Psychiatry 28: 54–64

    PubMed  CAS  Google Scholar 

  • Hsiao JK, Bartko JJ, Potter WZ (1989) Diagnosing diagnoses. Receiver operating characteristic methods and psychiatry. Arch Gen Psychiatry 46: 664–667

    PubMed  CAS  Google Scholar 

  • Hyman SE, Nestler EJ (1993) The molecular foundations of psychiatry. American Psychiatric Press, Washington London

    Google Scholar 

  • Joyce PR, Paykel ES (1989) Predictors of drug response in depression. Arch Gen Psychiatry 46: 89–99

    PubMed  CAS  Google Scholar 

  • Kendell RE, Brockington IF, Leff JP (1979) Prognostic implications of six alternative definitions of schizophrenia. Arch Gen Psychiatry 36: 25–31

    PubMed  CAS  Google Scholar 

  • Köpcke W (1994) Design, methodological and statistical issues in prediction research of neuroleptic response. In: Gaebel W, Awad AG (eds) Prediction of neuroleptic treatment outcome in schizophrenia. Concepts and methods. Springer, Wien, pp 155–164

    Google Scholar 

  • Kuny S, Stassen HH (1993) Speaking behaviour and voice sound characteristics in depressive patients during recovery. J Psychiatr Res 27: 289–307

    Article  PubMed  CAS  Google Scholar 

  • Lieberman JA, Kane JM, Sarantakos S et al. (1987) Prediction of relapse in schizophrenia. Arch Gen Psychiatry 44: 597–603

    PubMed  CAS  Google Scholar 

  • May PRA, Van Putten T, Yale C et al. (1976) Predicting individual responses to drug treatment in schizophrenia: a test dose model. J Nerv Ment Dis 162: 177–183

    Article  PubMed  CAS  Google Scholar 

  • May PRA, Goldberg SC (1978) Prediction of schizophrenic patients’ response to pharmacotherapy. In: Lipton MA, Dimascio A, Killam KF (eds) Psychopharmacology: a generation of progress. Raven Press, New York, pp 1139–1153

    Google Scholar 

  • May PRA, Van Putten T, Yale C (1980) Predicting outcome of antipsychotic drug treatment from early response. Am J Psychiatry 137: 1088–1089

    PubMed  CAS  Google Scholar 

  • Möller HJ, Kissling W, Zerssen D von (1983) Die prognostische Bedeutung des frühen Ansprechens schizophrener Patienten auf Neuroleptika für den weiteren stationären Behandlungsverlauf. Pharmacopsychiatry 16: 46–49

    Article  Google Scholar 

  • Nedopil N, Rüther E (1981) Initial improvement as predictor of outcome of neuroleptic treatment. Pharmacopsychiatry 14: 205–207

    Article  CAS  Google Scholar 

  • Nuechterlein KH (1987) Vulnerability models for schizophrenia: state of the art. In: Häfner H, Gattaz WF, Janzarik W (eds) Search for the cause of schizophrenia. Springer, Berlin Heidelberg New York Tokyo, pp 297–316

    Google Scholar 

  • Pickar D (1988) Perspectives on a time-dependent model of neuroleptic action. Schizophr Bull 14: 255–268

    PubMed  CAS  Google Scholar 

  • Pietzcker A, Gaebel W, Köpcke W et al. (1993) Continuous vs intermittent neuroleptic longterm treatment in schizophrenia-results of a German multicenter study. J Psychiatr Res 27: 321–339

    Article  Google Scholar 

  • Ranelli CJ, Miller RE (1981) Behavioral predictors of amitriptyline response in depression. Am J Psychiatry 138: 30–34

    Article  PubMed  CAS  Google Scholar 

  • Selbach H (1961) Über die vegetative Dynamik in der psychiatrischen Pharmakotherapie. Dtsch Med J 16: 511–517

    Google Scholar 

  • Strauss JS, Carpenter WT (1974) The prediction of outcome in schizophrenia. II. Relationships between predictor and outcome variables. Arch Gen Psychiatry 31: 37–42

    PubMed  CAS  Google Scholar 

  • Troisi A, Pasini A, Bersani G et al. (1989) Ethological predictors of amitriptyline response in depressed outpatients. J Affect Disord 17: 129–136

    Article  PubMed  CAS  Google Scholar 

  • Van Praag HM, Kahn RS, Asnis GM et al. (1987) Denosologization of biological psychiatry or the specificity of 5-HT disturbances in psychiatric disorders. J Affect Disord 13: 1–8

    Article  PubMed  Google Scholar 

  • Van Putten R, May PRA (1978) Subjective response as a predictor of outcome in pharmacotherapy. Arch Gen Psychiatry 35: 477–480

    PubMed  Google Scholar 

  • Woggon B (1992) Prädiktoren für das Ansprechen auf Psychopharmaka. In: Riederer P, Laux G, Pöldinger W (Hrsg) Neuro-Psychopharmaka, Bd. 1. Springer, Wien, S 475–484

    Google Scholar 

  • Woggon B, Baumann U (1983) Multimethodological approach in psychiatric predictor research. Pharmacopsychiatry 16: 175–178

    Article  CAS  Google Scholar 

Download references

Authors
  1. W. Gaebel
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Psychiatrische Klinik, Ludwig-Maximilians-Universität, Nußbaumstraße 7, D-80336, München, Germany

    Hans-Jürgen Möller

  2. Neurologische Klinik der Ruhr-Universität Bochum im St. Josef-Hospital, Gudrunstraße 56, D-44791, Bochum, Germany

    Horst Przuntek  & Thomas Büttner  & 

  3. Psychiatrische Klinik und Poliklinik, Universität Bonn, Sigmund-Freud-Straße 25, D-53105, Bonn, Germany

    Gerd Laux

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Gaebel, W. (1996). Prädiktion des Therapieerfolges bei psychiatrischen Erkrankungen: Ein Beitrag zu Konzept und Methodik psychiatrischer Prädiktorforschung. In: Möller, HJ., Przuntek, H., Laux, G., Büttner, T. (eds) Therapie im Grenzgebiet von Psychiatrie und Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61017-2_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-61017-2_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-60206-4

  • Online ISBN: 978-3-642-61017-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation