Zusammenfassung
Klagen über subjektiv empfundene Einbußen kognitiver Funktionen gehören zu den häufigen in der neuropsychiatrischen Praxis vorgetragenen Beschwerden. In einer Feldstudie waren nur etwa 60% dieser Symptome tatsächlich auf eine Demenz zurückzuführen (Kurz et al. 1991). Erster Schritt der ärztlichen Diagnose ist daher die diagnostische Abgrenzung der Demenz gegenüber anderen psychischen Störungen. Nach Diagnose des Syndroms „Demenz“ ist das Ziel der differentialdiagnostischen Abklärung die Identifikation der Krankheitsursache, um gegebenenfalls eine kausale Behandlung einzuleiten. Die klinische Demenzdiagnostik muß sich eines umfassenden klinischen, psychometrischen und apparativen Instrumentariums bedienen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Adams RD, Fisher CM, Hakim S et al. (1965) Symptomatik occult hydrocephalus with normal CSF pressure. N Engl J Med 273: 117–126
American Psychiatric Association (1987) Diagnostic and statistical manual of mental disorders, 3rd edn, revised. APA, Washington
Appleyard ME, Smith AD, Bergman P et al. (1987) Cholinesterase activities in cerebrospinal fluid of patients with senile dementia of Alzheimer type. Brain 110: 1309–1322
Babikian V, Ropper AH (1987) Binswanger’s disease: a review. Stroke 18: 2–12
Bamford KA, Caine ED (1988) Does “benign senescent forgetfulness” exist. Clin Geriatr Med 4: 897–916
Beal MF, Growdon JH, Mazurek MF, Martin JB (1986) CSF somatostatin-like immunoreactivity in dementia. Neurology 36: 294–297
Benson DF, Lamay M, Patten D et al. (1970) Diagnosis of normal pressure hydrocephalus. N Engl J Med 283: 609–615
Benton AL (1986) Der Benton-Test. Huber, Bern Stuttgart Toronto
Binswanger 0 (1894) Die Abgrenzung der allgemeinen progressiven Paralyse. Berl Klin Wochenschr 31: 1103–1105
Blass JP, Gibson GE (1993) Nonneural markers in Alzheimer disease. Alzheimer Dis Assoc Dis 6: 205–224
Bleuler E (1966) Lehrbuch der Psychiatrie. Springer, Berlin, Heidelberg, New York
Brun A (1993) The 2nd international conference on frontal lobe degeneration of non-Alzheimer type. Dementia 4: 123–236
Büttner Th, Dorndorf W (1988) Virale Enzephalitiden. Erfahrungen mit 53 Patienten aus Mittelhessen. Fortschr Neurol Psychiatr 56: 315–325
Büttner Th, Berlit P, Kaiser N, Dorndorf W (1989) Prognose viraler Enzephalitiden. In: Fischer PA, Baas H, Enzensberger W (Hrsg) Verhandlungen der Deutschen Gesellschaft für Neurologie, Bd. 5. Springer, Heidelberg Berlin New York, S. 714–717
Büttner Th, Schilling G, Hornig CR, Dorndorf W (1991) Thalamusinfarkte-Klinik, neuropsychologische Befunde, Prognose. Fortschr Neurol Psychiatr 59: 479–487
Büttner Th, Traupe M, Langkafel M, Schaffstein J, Przuntek H (1992) Transitorische Thalamusischämie als Ursache rezidivierender Verwirrtheitszustände. In: Huffmann G, Braune J, Griewing B (Hrsg) Durchblutungsstörungen im Bereich des Nervensystems. Einhorn, Reinbeck, S. 326–331
Carney MWP, Chary TKN, Robotis P, Childs A (1987) Ganser syndrome and its management. Br J Psychiatry 151: 697–700
Cramon DV, Kühnlein J, Wolfram A (1981) Die thalamische Demenz. Fortschr Neurol Psychiatr 49: 129–135
Crook TH, Bartus RT, Ferris SH et al. (1986) Age-associated memory impairment. Proposed diagnostic criteria and measures of clinical change: report of a National Institute of Mental Health work group. Dev Neuropsychol 2: 261–276
Cutler NR (1988) Utility of biologic markers in the evaluation and diagnosis of Alzheimer’s disease. Brain Dysfunction 1: 12–31
Dick JPR, Guiloff RJ, Stewart A et al. (1984) Mini-mental state examination in neurological patients. J Neurol Neurosurg Psychiatry 47: 496–499
Diener HC, Hacke W, Hennerici M, Lehrl S (1992) Zerebrale Mikroangiopathie (subcortikale arteriosklerotische Enzephalopathie)-eine operationale Definiton. In: Häfner H, Hennerici M (Hrsg) Psychische Krankheiten und Hirnfunktion im Alter. Fischer, Stuttgart, S. 41–43
Dierks T, Maurer K (1990) Refernce-fre evaluation of auditory evoked potentials-P300 in aging and dementia. In: Dostert P, Riederer P, Strolin Benedetti M, Roncucci R (eds) Early markers in Parkinson’s and Alzheimer’s disease. Springer, Wien New York, pp 197–208
Dierks T, Perisic I, Frölich L et al. (1991) Topography of the quantitative electroencephalogram in dementia of the Alzheimer type: relation to severity of dementia. Psychiatry Res Neuroimaging 40: 181–194
Erzigkeit H (1989) The SKT-a short cognitive performance test as an instrument for the assessment of clinical efficiacy of cognition enhancers. In: Bergener M, Reisner B (eds) Diagnosis and treatment of senile dementia. Springer, Berlin Heidelberg New York Tokyo, pp 164–174
Eslinger PJ, Damasio AR, Benton AL, van-Allen M (1985) Neuropsychological detection of abnormal mental decline in older persons. JAMA 253: 670–674
Etcheberrigaray R, Ito E, Oka K et al. (1993) Potassium channel dysfunction in fibroblasts identifies patients with Alzheimer’s disease. Proc Natl Acad Sci USA 90: 8209–8213
Felgenhauer K (1990) Psychiatric disorders in the encephalitic form of multiple sclerosis. J Neurol 237: 11–18
Fischer P, Jellinger K, Gatterer G, Danielczyk W (1991) Prospektive neuropathological validation of Hachinski’s Ischaemic Score in dementias. J Neurol Neurosurg Psychiatr 54: 580–583
Folstein MF, Folstein SE, McHugh PR (1975) “Mini-mental state”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12: 189–198
Foltz EL, Ward AA (1956) Communicating hydrocephalus from subarachnoidal bleeding. J Neurosurg 13: 546–566
Forette F, Henry JF, Orgogozo JM et al. (1989) Reliability of clinical criteria for the diagnosis of dementia. A longitudinal study. Arch Neurol 46: 646–648
Friedland RP, Koss E, Haxby JV et al. (1988) Alzheimer’s disease: clinical and biological heterogeneity. Ann Intern Med 109: 298–311
Gilleard CJ, Kellett JM, Coles JA et al. (1992) The St. George’s dementia bed investigation study-a comparison of clinical and pathological diagnosis. Acta Psychiatr Scand 55: 264–269
Gilman S, Adams K, Koeppe RA et al. (1990) Cerebellar and frontal hypometabolism in alcoholic cerebellar degeneration studied with positron emission tomography. Ann Neurol 28: 750–757
Glenner GG (1980) Amyloid deposits and amyloidosis. N Engl J Med 302: 1283–1292
Goate AM, Haynes AR, Owen MJ et al. (1989) Predisposing locus for Alzheimer’s disease on chromosome 21. Lancet 1: 352–355
Graff-Radford NR, Damasio H, Yamada T et al. (1985) Nonhaemorrhagic thalamic infarction. Clinical, neuropsychological and electrophysiological findings in four anatomical groups defined by computerized tomography. Brain 108: 485–516
Gräßel E (1994) Psychometrische Testverfahren beim Parkinson-Syndrom and anderen degenerativen Hirnerkrankungen. In: Huffmann G, Braune HJ, Henn KH (Hrsg) Extrapyramidal-motorische Erkrankungen. Einhorn, Reinbeck, S. 247–256
Gustafson L (1992) Clinical classification of dementia conditions. Acta Neurol Scand (Suppl) 139: 16–20
Hachinski VC, Iliff LD, Zihlka E et al. (1975) Cerebral blood flow in dementia. Arch Neurol 32: 632–637
Hachinski VC (1991) Multi-infarct dementia: a reappraisal. Alzheimer Dis Assoc Dis 5: 64–68
Halligan FR, Reznikoff M, Friedman HP, LaRocca NG (1988) Cognitive dysfunction and change in multiple sclerosis. J Clin Psychol 44: 540 – 548
Hansen LA, Salmon D, Galasko D et al. (1990) The Lewy body variant of Alzheimer’s disease: a clinical and pathological entity. Neurology 40: 1–8
Heiss WD, Szelies B, Adams R et al. (1990) PET scanning for the detection of Alzheimer’s disease. In: Dostert P, Riederer P, Strolin Benedetti M, Roncucci R (eds) Early markers in Parkinson’s and Alzheimer’s disease. Springer, Wien New York, pp 181–196
Heron EA, Kritchevsky M, Delis DC (1991) Neuropsychological presentation of Ganser symptoms. J Clin Exp Neuropsychol 13: 652–666
Jack CRJ, Petersen RC, O’Brien PC, Tangalos EG (1992) MR-based hippocampal volumetry in the diagnosis of Alzheimer’s disease. Neurology 42: 183–188
Joachim CL, Morris JH, Selkoe DJ (1988) Clinically diagnosed Alzheimer’s disease: autopsy results in 150 cases. Ann Neurol 24: 50–56
Knopman DS, Ryberg S (1989) A verbal memory test with high predictive accuracy for dementia of the Alzheimer type. Arch Neurol 46: 141–145
Koller WC (1992) Handbook of Parkinson’s disease. Dekker, New York
Kosaka K (1990) Diffuse Lewy body disease in Japan. J Neurol 237: 197–204
Kozachuk WE, DeCarli C, Shapiro MB et al. (1990) White matter hyperintensities in dementia of Alzheimer’s type and in healthy subjects with cerebrovascular risk. Arch Neurol 47: 1306–1310
Kral VA (1972) Senile dementia and normal aging. Can Psychiatr Assoc J: 25–30
Kuhl DE, Small GW, Riege WH et al. (1987) Abnormal PET-FDG scans in early Alzheimer’s disease. J Nucl Med 28: 645
Kuskowski MA, Morley GK, Malone SM, Okaya AJ (1991) Longitudinal measurement of brainstem auditory evoked potentials in patients with dementia of the Alzheimer type. Int J Neurosci 60: 79–84
Kurz A, Haupt M, Müllers-Stein M et al. (1991) Alzheimer-Sprechstunde-Erfahrungen in der Diagnostik and Therapie von organisch bedingten psychischen Störungen. Psychiatr Prax 18: 109–114
Ladurner G, Pieringer W, Sager WD (1981) Depressive syndromes in middle age and organic brain disease. Psychiatria Clin 14: 97–105
Lehrl S (1989) Mehrfach-Wortschatz-Intelligenztest MWT-B. Perimed, Erlangen
Lehrl S, Fischer B (1992) c. 1. Test zur raschen Objektivierung cerebraler Insuffizienzen. Vless Verlag, Ebersberg
Lennox G (1992) Lewy body dementia. In: Rossor MN (ed) Baillier’s clinical neurology, vol 1. Bailliere Tindall, London
Lishman WA (1981) Cerebral disorder in alcoholism. Syndromes of impairment. Brain 104: 1–20
McKhann D, Drachman D, Folstein M et al. (1984) Clinical diagnosis of Alzheimer’s disease. Neurology 34: 939–944
McRae A, Blennow K, Wallin A et al. (1991) The presence of antibrain antibodies in the CSF of some Alzheimer disease patients: correlation with CSF parameters. In: Dostert P, Riederer P, Strolin Benedetti M, Roncucci R (eds) Early markers in Paekinson’s and Alzheimer’s disease. Springer, Wien New York, pp 257–265
Mendez MF, Mastri AR, Sung HJ, Frey WH (1992) Clinically diagnosed Alzheimer disease: Neuropathologic findings in 650 cases. Alzheimer Dis Assoc Dis 6: 35–43
Miller WR (1975) Psychological deficit in depression. Psychol Bull 82: 238–260
Miller NE (1980) Mood measurements in senile brain disease. In: Cole JO, Barret JEE (eds) Psychopathology of the aged. Raven, New York
Mirra SS, Heyman A, McKeel D et al. (1991) The consortium to establish a registry for Alzheimer’s disease (CERAD). Part II. Standardization of the neuropathologie assessment of Alzheimer’s disease. Neurology 41: 479–486
Morris JC, Mohs RC, Rogers H et al. (1988) Consortium to establish a registry for Alzheimer’s disease (CERAD). Clinical and neuropsychological assessment of Alzheimer’s disease. Psychopharmacol Bull 24: 641–652
Morris JC, Heyman A, Mohs RC et al. (1989) The consortium to establish a registry for Alzheimer’s disease (CERAD). Part I. Clinical and neuropsychological assessment of Alzheimer’s disease. Neurology 39: 1159–1165
Morris JC, McKeel DW, Storandt EH et al. (1991) Very mild Alzheimer’s disease: Informant-based clinical, psychometric, and pathologic distinction from normal aging. Neurology 1991; 41: 469–478
Navia BA, Cho ES, Petito CK, Price RW (1986) The AIDS-dementia complex. II. Neuropathology. Ann Neurol 19: 525–535
Neary D, Snowden JS, Mann DMA (1993) The clinical pathological correlates of lobar atrophy. Dementia 4: 154–159
Paulson GW (1976) The neurological examination in dementia. Contemp Neurol Ser 15: 169–188
Polich J, Ladish C, Bloom FE (1990) P 300 assessment of early Alzheimer’s disease. Electroencephalogr Clin Neurophysiol 77: 179–189
Rafal RD, Posner MI, Walker SA, Friedrich FJ (1984) Cognition and the basal ganglia. Separating mental and motor components of performance in Parkinson’s disease. Brain 107: 1083–1094
Regli F (1989) Cerebral amyloid angiopathy. In: Toole JF (ed) Handbook of clinical neurology: Vascular diseases, part II, vol. 54. Elsevier, Amsterdam New York, pp 333–344
Rogers D (1986) Bradyphrenia in parkinsonism: a historical review. Psychol Med 16: 257–265
Roman GC, Tatemichi TK, Erkinjuntti T et al. (1993) Vascular dementia: Diagnostik criteria for research studies. Report of the NINDS-AIREN International Workshop. Neurology 43: 250–260
Rosen WG, Mohs RC, Davis KL (1984) A new rating scale for Alzheimer’s disease. Am J Psychiatry 141: 1356–1364
Scheltens P, Barkhof F, Valk J et al. (1992) White matter lesions on magnetic resonance imaging in clinically diagnosed Alzheimer’s disease. Evidence for heterogeneity. Brain 115: 735–748
Sheridan PH, Sato S, Foster N et al. (1988) Relation of EEG alpha background to parietal lobe function in Alzheimer’s disease as measured by positron emission tomography and psychometry. Neurology 38: 747–750
Sternberg DE, Jarvik ME (1976) Memory functions in depression. Arch Gen Psychiatry 33: 219–224
St. George-Hyslop PH, Tanzi RE, Polinsky RJ (1987) The genetic defect causing familial Alzheimer’s disease maps on chromosome 21. Science 135: 885–890
Strittmatter WJ, Saunders AM, Schmechel D et al. (1993) Apolipoprotein E: high avidity binding to 13-Amyloid and increased frequency of type 4 allele in late onset familial Alzheimer disease. Proc Natl Acad Sci USA 90: 1977–1981
Sunderland T, Rubinow DR, Tariot PN et al. (1987) CSF somatostatin in patients with Alzheimer’s disease, older depressed patients, and age-matched control subjects. Am J Psychiatr 144: 1313–1316
Swanson RA, Schmidley JW (1985) Amnestic syndrome and vertical gaze palsy: Early detection of bilateral thalamic infarction by CT and NMR. Stroke 16: 823–827
Thienhaus OJ, Hartford JT, Skelly MF, Bosmann HB (1985) Biologic markers in Alzheimer’s disease. J Am Geriatr Soc 33: 715–726
Tierney MC, Fisher RH, Lewis A) et al. (1988) The NINCDS-ADRDA work group criteria for the clinical diagnosis of probable Alzheimer’s disease: a clinicopathological study of 57 cases. Neurology 38: 359–364
Tuokko H, Gallie KA, Crokket DJ (1990) Patterns of memory deterioration in normal and memory impaired elderly. Dev Neuropsychol 6: 291–300
Visser SL (1985) EEG and evoked potentials in the diagnosis of dementias. In: Traber J, Gispen WH (eds) Senile dementia of the Alzheimer type. Early diagnosis, neuropathology and animal models. Springer, Berlin Heidelberg New York, pp 102–116
Waldemar G, Walovitch RC, Andersen AR et al. (1994) 99m-Tc-bicisate (Neurolite) SPECT brain imaging and cognitive impairment in dementia of the Alzheimer’s type: A blinded read of image sets from a multicenter SPECT trial. J Cereb Blood Flow Metab 14 (Suppl 1 ): S99–S105
Weinberger DR, Gibson RE, Coppola R et al. (1989) 123IodoQNB SPECT in Alzheimer’s and Pick’s disease. American Psychiatric Association, San Francisco (Kongreßband )
Weinstein HC, Scheltens P, Hijdra A, van Royen EA (1993) Neuroimaging in the diagnosis of Alzheimer’s disease. II. Positron and single photon emission tomography. Clin Neurol Neurosurg 95: 81–91
Welsh KA, Butters N, Hughes J et al. (1991) Detection of abnormal memory decline in mild cases of Alzheimer’s disease using CERAD neuropsychological measures. Arch Neurol 48: 278–281
Wiley CA, Achim C (1994) Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome. Ann Neurol 36: 673–676
Wolozin B, Davies P (1987) Alzheimer-related neuronal protein A 68: specifity and distribution. Ann Neurol 22: 521–526
Yoshimura M, Yamanouchi H, Kuzuhara S et al. (1992) Dementia in cerebral amyloid angiopathy: a clinicopathological study. J Neurol 239: 441–450
Zaudig M, Mittelhammer J, Hiller Wet al. (1991) SIDAM-a structured interview for the diagnosis of dementia of the Alzheimer type, multi-infarct dementia and dementias of other aetiology according to ICD-10 and DSM-III-R. Psychol Med 21: 225–236
Zweig RM, Cardillo JE, Cohen M et al. (1993) The locus ceruleus and dementia in Parkinson’s disease. Neurology 43: 986–991
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Büttner, T. (1996). Diagnose und Differentialdiagnose der Demenz. In: Möller, HJ., Przuntek, H., Laux, G., Büttner, T. (eds) Therapie im Grenzgebiet von Psychiatrie und Neurologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61017-2_13
Download citation
DOI: https://doi.org/10.1007/978-3-642-61017-2_13
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-60206-4
Online ISBN: 978-3-642-61017-2
eBook Packages: Springer Book Archive