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Drug Interactions and Drug-Metabolising Enzymes

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Mechanisms of Drug Interactions

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 122))

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Abstract

Induction and inhibition of cytochrome P450 enzymes are mechanisms that underly some of the more serious drug-drug interactions; it is therefore pertinent that the structure, distribution and essential roles of cytochromes P450 are reviewed.

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  1. P. F. D’Arcy
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Editors and Affiliations

  1. School of Pharmacy, The Queen’s University of Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, Belfast, N. Ireland

    Patrick F. D’Arcy OBE, Ph.D., D.Sc.

  2. School of Pharmacy, The Queen’s University of Belfast, Medical Biology Centre, 97 Lisburn Road, BT9 7BL, Belfast, N. Ireland

    James C. McElnay Ph.D. (Director) (Director)

  3. Pharmacokinetics and Drug Metabolism, Parke-Davis Pharmaceutical Research, 2800 Plymouth Road, MI 48105, Ann Arbor, USA

    Peter G. Welling Ph.D., D.Sc. (Vice President) (Vice President)

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D’Arcy, P.F. (1996). Drug Interactions and Drug-Metabolising Enzymes. In: D’Arcy, P.F., McElnay, J.C., Welling, P.G. (eds) Mechanisms of Drug Interactions. Handbook of Experimental Pharmacology, vol 122. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61015-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-61015-8_5

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