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Antimicrobial Drugs

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Drug-Induced Hepatotoxicity

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 121))

Abstract

Among the large number of antimicrobial agents, there are some that lead to little or no injury (e.g., streptomycin, penicillin k), some that lead to idiosyncratic injury (e.g., erythromycin), and some that are intrinsic hepatotoxins (e.g., tetracycline). Some can lead to cytotoxic (hepatocellular) injury with either necrosis (Figs. 1,2) or steatosis (Fig. 3). Some lead to cholestasis (Fig. 4) or mixed injury (Fig. 5). The necrosis is usually nonzonal (Fig. 1) and uncommonly zonal (Fig. 2). Several drugs can lead to chronic hepatitis (Fig. 6) and some to chronic cholestasis (Fig. 7). In Table 1 are listed the various antimicrobial agents and the hepatic injury associated with their use.

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Authors
  1. H. J. Zimmerman
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  2. K. G. Ishak
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Editor information

Editors and Affiliations

  1. Department of Pathology Division of Experimental Pathology, University of Toronto, Medical Sciences Building, 1 King’s College Circle, M5S 1A8, Toronto, Ontario, Canada

    Ross G. Cameron M.D., Ph.D.

  2. Department of Clinical Biochemistry Banting Institute, University of Toronto, Room 521, 100 College Street, M5G 1L5, Toronto, Ontario, Canada

    George Feuer Ph.D.

  3. Parke-Davis Pharmaceutical Research Division Department of Pathology and Experimental Toxicology, Warner Lambert Company, 2800 Plymouth Road, 48105, Ann Arbor, MI, USA

    Felix A. de la Iglesia M.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Zimmerman, H.J., Ishak, K.G. (1996). Antimicrobial Drugs. In: Cameron, R.G., Feuer, G., de la Iglesia, F.A. (eds) Drug-Induced Hepatotoxicity. Handbook of Experimental Pharmacology, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61013-4_20

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  • DOI: https://doi.org/10.1007/978-3-642-61013-4_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64657-7

  • Online ISBN: 978-3-642-61013-4

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