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Reye’s Syndrome

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Drug-Induced Hepatotoxicity

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 121))

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Abstract

REYE, MORGAN and BARAL in 1963 in their classic paper described a distinct disease entity in children with characteristic clinicopathologic features (encephalopathy and fatty degeneration of the viscera). Manifestations of the disease included viral prodrome usually characterized by upper respiratory infection followed by severe vomiting after which mental changes and coma eventually occurred. Clinically, biochemically and histologically there was evidence of fatty liver, hypoglycemia and cerebral edema which eventually resulted in the death of 17 of 21 children reported in the series. In 1958, KAPILLA et al. had reported neurologic and hepatic disorders associated with influenza in children who had died following complications of the infection in India. In 1963, JOHNSON et al. who was then working at the Center for Disease Control, United States Public Health Service, and North Carolina State Health Department also described similar cases. However. whereas the Australian patients had been seen over a decade, the cases from North Carolina were clustered within 4 months and had occurred in association with an epidemic of influenza B. The association of chemical toxins with fatty degeneration has been speculated upon since the initial descriptions of the entity. REYE commented on the resemblance of Jamaican vomiting sickness and speculated about the possible role of toxins (REYE et al. 1963: LINNEMAN et al. 1975).

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  1. R. R. Varma
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Editors and Affiliations

  1. Department of Pathology Division of Experimental Pathology, University of Toronto, Medical Sciences Building, 1 King’s College Circle, M5S 1A8, Toronto, Ontario, Canada

    Ross G. Cameron M.D., Ph.D.

  2. Department of Clinical Biochemistry Banting Institute, University of Toronto, Room 521, 100 College Street, M5G 1L5, Toronto, Ontario, Canada

    George Feuer Ph.D.

  3. Parke-Davis Pharmaceutical Research Division Department of Pathology and Experimental Toxicology, Warner Lambert Company, 2800 Plymouth Road, 48105, Ann Arbor, MI, USA

    Felix A. de la Iglesia M.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Varma, R.R. (1996). Reye’s Syndrome. In: Cameron, R.G., Feuer, G., de la Iglesia, F.A. (eds) Drug-Induced Hepatotoxicity. Handbook of Experimental Pharmacology, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61013-4_14

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  • DOI: https://doi.org/10.1007/978-3-642-61013-4_14

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