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Pediatric Hepatic Drug Reactions

  • Chapter
Drug-Induced Hepatotoxicity

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 121))

Abstract

Children are considered less susceptible to drug hepatotoxicity than adults. This is thought to be due to differences in their hepatic drug metabolism which protect against drug hepatotoxicity. However, most children take fewer medications than adults. Children are less likely to be obese; they generally do not smoke or drink. Drug hepatotoxicity does occur in children, and adolescents may be at equivalent risk for drug hepatotoxicity as adults. Difficulties in diagnosing drug hepatotoxicity in children. and consequent underreporting of these adverse drug reactions. may also contribute to the perceived rarity of pediatric hepatic drug reactions.

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  1. E. A. Roberts
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Editors and Affiliations

  1. Department of Pathology Division of Experimental Pathology, University of Toronto, Medical Sciences Building, 1 King’s College Circle, M5S 1A8, Toronto, Ontario, Canada

    Ross G. Cameron M.D., Ph.D.

  2. Department of Clinical Biochemistry Banting Institute, University of Toronto, Room 521, 100 College Street, M5G 1L5, Toronto, Ontario, Canada

    George Feuer Ph.D.

  3. Parke-Davis Pharmaceutical Research Division Department of Pathology and Experimental Toxicology, Warner Lambert Company, 2800 Plymouth Road, 48105, Ann Arbor, MI, USA

    Felix A. de la Iglesia M.D.

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Roberts, E.A. (1996). Pediatric Hepatic Drug Reactions. In: Cameron, R.G., Feuer, G., de la Iglesia, F.A. (eds) Drug-Induced Hepatotoxicity. Handbook of Experimental Pharmacology, vol 121. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61013-4_13

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