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Antipsychotics pp 43–75Cite as

Interaction of Antipsychotic Drugs with Dopamine Receptor Subtypes

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 120))

Abstract

Until the mid-twentieth century, patients suffering from psychiatric diseases such as schizophrenia were subjected to barbiturates, insulin coma, electroconvulsive therapy, and brain surgery, all of which provided little or no therapeutic benefit. The first major breakthrough in the treatment of psychiatric diseases occurred in the early 1950s with the discovery and introduction of chlorpromazine as the first effective neuroleptic (Delay et al. 1952). Improved neuroleptic drugs were subsequently developed, and the search began for the common “site of action” of these drugs.

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Authors
  1. Deborah Hartman
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  2. Frederick Monsma
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  3. Olivier Civelli
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Editors and Affiliations

  1. Department of Psychiatry, Washington University, School of Medicine, 4940 Children’s Place, St. Louis, MO 63110-1093, USA

    John G. Csernansky (M.D.) (M.D.)

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© 1996 Springer-Verlag Berlin Heidelberg

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Hartman, D., Monsma, F., Civelli, O. (1996). Interaction of Antipsychotic Drugs with Dopamine Receptor Subtypes. In: Csernansky, J.G. (eds) Antipsychotics. Handbook of Experimental Pharmacology, vol 120. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-61007-3_3

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  • DOI: https://doi.org/10.1007/978-3-642-61007-3_3

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