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Phencyclidine: A Drug of Abuse and a Tool for Neuroscience Research

  • Chapter
Pharmacological Aspects of Drug Dependence

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 118))

Abstract

Phencyclidine (PCP; 1-(1-phenylcyclohexyl)piperidine hydrochloride) was launched as an intravenous anesthetic under the trade name Sernyl by Parke, Davis and Company in the late 1950s. Unlike other general anesthetics, phencyclidine prodecud unconsciousness, absence of pain perception and amnesia without suppressing vital reflexes; the so-called dissociative anesthetic state induced by phencyclidine differed qualitatively from anesthesia induced by depressant drugs and volatile anesthetics (DOMINO 1964). However, unwanted psychotomimetic effects, often resembling acute schizophrenic anesthesia and the drug was withdrawn from clinical development (GREIFENSTEIN et al. 1958; DOMINO 1964).

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Authors
  1. R. L. Balster
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  2. J. Willetts
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Editors and Affiliations

  1. University Psychiatric Center, Wayne State University School of Medicine, 2751 E. Jefferson Avenue, 48207, Detroit, MI, USA

    Charles R. Schuster Ph.D.

  2. Director, The National Institute on Drug Abuse, Addiction Research Center, P.O. Box 5180, 21224, Baltimore, MD, USA

    Michael J. Kuhar Ph.D.

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© 1996 Springer-Verlag Berlin Heidelberg

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Balster, R.L., Willetts, J. (1996). Phencyclidine: A Drug of Abuse and a Tool for Neuroscience Research. In: Schuster, C.R., Kuhar, M.J. (eds) Pharmacological Aspects of Drug Dependence. Handbook of Experimental Pharmacology, vol 118. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60963-3_6

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  • DOI: https://doi.org/10.1007/978-3-642-60963-3_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64631-7

  • Online ISBN: 978-3-642-60963-3

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