Abstract
The prostate is the largest accessory reproductive gland in the male, and exhibits a marked propensity for pathologic behavior. However, little is known about its specific function. The importance of the prostate gland to pathologists is constantly increasing. Prostate surgery is the most common surgical procedure performed on American males, most often because of prostatic hyperplasia. Radical prostatectomy is now widely used in the attempt to cure clinically localized prostate cancer. Many efforts of urologists, oncologists, and pathologists are concentrated on the diagnosis of premalignant lesions and early prostate cancer and the search for reliable prognostic parameters (Chiarodo 1991; Bostwick et al. 1992b; Ware 1994).
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References
Abrahamsson P-A, di Sant’Agnese PA (1993) Neuroendocrine cells in the human prostate gland. J Androl 14: 307–309
Abrahamsson P-A, Wadström LB, Alumets J, Falkmer S, Grimelius L (1986) Peptide-hormone-and serotonin-immunoreactive cells in normal and hyperplastic prostate glands. Pathol Res Pract 181: 675–683
Abrahamsson P-A, Wadström LB, Alumets J, Falkmer S, Grimelius L (1987) Peptide-hormone-and serotonin-immunoreactive tumour cells in carcinoma of the prostate. Pathol Res Pract 182: 298–307
Abrahamsson P-A, Falkmer S, Fäit K, Grimelius L (1989) The course of neuroendocrine differentiation in prostatic carcinomas. An immunohistochemical study testing chromogranin A as an “endocrine marker”. Pathol Res Pract 185: 373–380
Adlakha H, Bostwick DG (1994) Paneth cell-like change in prostatic adenocarcinoma represents neuroendocrine differentiation: report of 30 cases. Hum Pathol 25: 135–139
Allsbrook WC, Simms WW (1992) Histochemistry of the prostate. Hum Pathol 23: 297–305
Aprikian AG, Cordon-Cardo C, Fair WR, Reuter VE (1993) Characterization of neuroendocrine differentiation in human benign prostate and prostatic adenocarcinoma. Cancer 71: 3952–3965
Aprikian AG, Cordon-Cardo C, Fair WR, Zhang Z-F, Bazinet M, Hamdy SM, Reuter VE (1994a) Neuroendocrine differentiation in metastatic prostate adenocarcinoma. J Urol 151: 914–919
Aprikian AG, Sarkis AS, Fair WR, Zhang Z-F, Fuks Z, CordonCardo C (1994b) Immunohistochemical determination of p53 protein nuclear accumulation in prostatic adenocarcinoma. J Urol 151: 1276–1280
Armas OA, Aprikian AG, Melamed J et al. (1994) Clinical and pathobiological effects of neoadjuvant total androgen ablation therapy on clinically localized prostatic adenocarcinoma. Am J Surg Pathol 18: 979–991
Aumüller H (1983) Morphologic and endocrine aspects of prostatic function. Prostate 4: 195–214
Ayala AG, Ro JY, Babaian R, Troncosa P, Grignon DJ (1989) The prostatic capsule: does it exist? Its importance in the staging and treatment of prostatic carcinoma. Am J Surg Pathol 13: 21–27
Benoit G, Jardin A, Gillot C (1993) Reflections and suggestions on the nomenclature of the prostate. Surg Radiol Anat 15: 325–332
Berner A, Nesland JM, Waehre H, Silke J, Fossa SD (1993) Hormone resistant prostatic adenocarcinoma. An evaluation of prognostic factors in pre-and post-treatment specimens. Br J Cancer 68: 380–384
Bonkhoff H, Remberger K (1993) Widespread distribution of nuclear androgen receptors in the basal cell layer of the normal and hyperplastic human prostate. Virchows Arch [A] 422: 35–38
Bonkhoff H, Stein U, Remberger K (1993) Androgen receptor status in endocrine-paracrine cell types of the normal, hyperplastic, and neoplastic human prostate. Virchows Arch [A] 423: 291–294
Bonkhoff H, Stein U, Remberger K (1994a) Multidirectional differentiation in the normal, hyperplastic, and neoplastic human prostate: simultaneous demonstration of cell-specific epithelial markers. Hum Pathol 25: 42–46
Bonkhoff H, Stein U, Remberger K (1994b) The proliferative function of basal cells in the normal and hyperplastic human prostate. Prostate 24: 114–118
Bookstein R, Allred D (1993) Recessive oncogenes. Cancer 71: 1179–1186
Bookstein R, MacGrogan D, Hilsenbeck SG, Sharkey F, Allred DC (1993) p53 is mutated in a subset of advanced stage prostate cancers. Cancer Res 53:3369–3373
Bostwick DG (1994a) Prostate-specific antigen. Current role in diagnostic pathology of prostate cancer. Am J Clin Pathol 102 (Suppl 1): S31 - S37
Bostwick DG (1994b) Grading prostate cancer. Am J Clin Pathol 102 (Suppl 1): S38 - S56
Bostwick DG (1994c) Gleason grading of prostatic needle biopsies. Correlation with grade in 316 matched prostatectomies. Am J Surg Pathol 18: 796–803
Bostwick DG, Egbert BM, Fajardo LF (1982) Radiation injury of the normal and neoplastic prostate. Am J Surg Pathol 6: 541–551
Bostwick DG, Cooner WH, Denis L, Jones GW, Scardino PT, Murphy GP (1992a) The association of benign prostatic hyperplasia and cancer of the prostate. Cancer 70 (Suppl): 291–301
Bostwick DG, Montironi R, Wagle R et al. (1992b) Current and proposed biologic markers in prostate cancer, J Cell Biochem Suppl 16H: 65–67
Bostwick DG, Amin MB, Dundore P, Marsh W, Schultz DS (1993a) Architectural patterns of high-grade prostatic intraepithelial neoplasia. Hum Pathol 24: 298–310
Bostwick DG, Graham SD, Napalkov P et al. (1993b) Staging of early prostate cancer: a proposed tumor volume-based prognostic index. Urology 41: 403–411
Bostwick DG, Srigley J, Grignon D et al. (1993c) Atypical adenomatous hyperplasia of the prostate: morphologic criteria for its distinction from well-differentiated carcinoma. Hum Pathol 24: 819–832
Bostwick DG, Dousa MK, Crawford BG, Wollan PC (1994) Neuroendocrine differentiation in prostatic intraepithelial neoplasia and adenocarcinoma. Am J Surg Pathol 18: 1240–1246
Brinkman AO, Jenster G, Kuiper GGJM et al. (1992) The human androgen receptor: structure/function relationship in normal and pathological situations. J Steroid Biochem Mol Biol 41: 361–368
Byar DP, Mostofi FK, Vacurg (1972) Carcinoma of the prostate: prognostic evaluation of certain pathologic features in 208 radical prostatectomies examined by the step section technique. Cancer 30: 5–13
Capella C, Usellini L, Buffa R, Frigerio B, Solcia E (1981) The endocrine component of prostatic carcinomas, mixed adenocarcinoma-carcinoid tumours and non-tumour prostate. Histochemical and ultrastructural identification of the endocrine cells. Histopathology 5: 175–192
Casamento J, Abrahamsson P-A, Nakada SY, di Sant’Agnese PA, de Mesy Jensen KL, Cockett ATK (1992) Prognostic significance of neuroendocrine differentiation in prostatic carcinoma. J Urol 147: 332A
Cher ML, Chew K, Rosenau W, Carroll PR (1995) Cellular proliferation in prostatic adenocarcinoma as assessed by bromodeoxyuridine uptake and Ki-67 and PCNA expression. Prostate 26: 87–93
Chiarodo A (ed) (1991) National Cancer Institute roundtable on prostate cancer: future research directions. Meeting Report. Cancer Res 51: 2498–2505
Chodak GW, Kranc DM, Puy LA, Tihada H, Johnson K, Chang C (1992) Nuclear localization of androgen receptor in heterogeneous samples of normal, hyperplastic and neoplastic human prostate. J Urol 147: 798–803
Christensen WN, Partin AW, Walsh PC, Epstein JI (1990) Pathologic findings in clinical stage A2 prostate cancer. Relation of tumor volume, grade, and location to pathologic stage. Cancer 65: 1021–1027
Christensen WN, Steinberg G, Walsh PC, Epstein JI (1991) Prostatic duct adenocarcinoma. Findings at radical prostatectomy. Cancer 67: 2118–2124
Christopher ME, Seftel AD, Sorensen K, Resnick MI (1991) Small cell carcinoma of the genitourinary tract: an immunohistochemical, electron microscopic and clinicopathological study. J Urol 146: 382–388
Cohen MK, Arber DA, Coffield KS, Keegan GT, McClintock J, Speights VO (1994) Neuroendocrine differentiation in pro-static adenocarcinoma and its relationship to tumor progression. Cancer 74: 1899–1903
Cohen RJ, Glezerson G, Haffejee Z, Afrika D (1990) Prostatic carcinoma: histological and immunohistological factors affecting prognosis. Br J Urol 66: 405–410
Cunha GR, Chung LWK, Shannon JM et al. (1980) Stromalepithelial interactions in sex differentiation. Biol Reprod 22: 19–42
Currin SM, Lee SE, Walther PJ (1988) Flow cytometric analysis of comedocarcinoma of the prostate: an uncommon histopathological variant of prostatic adenocarcinoma. J Urol 140: 96–100
Dauge MC, Delmas V (1987) APUD type endocrine tumour of the prostate. Incidence and prognosis in association with adenocarcinoma. Prog Clin Biol Res 243: 529–531
de la Torre M, Haggman M, Brandstedt S, Busch C (1993) Prostatic intraepithelial neoplasia and invasive carcinoma in total prostatectomy specimens: distribution, volume and DNA ploidy. Br J Urol 72: 207–213
di Sant’Agnese PA (1992) Neuroendocrine differentiation in carcinoma of the prostate. Diagnostic, prognostic, and therapeutic implications. Cancer 70 (Suppl): 254–268
di Sant’Agnese PA, Cockett ATK (1994) The prostatic endocrine-paracrine (neuroendocrine) regulatory system and neuroendocrine differentiation in prostatic carcinoma: a review and future directions in basic research. J Urol 152: 1927–1931
di Sant’Agnese PA, de Mesy Jensen KL (1984) Endocrineparacrine cells of the prostate and prostatic urethra: an ultrastructural study. Hum Pathol 15: 1034–1041
di Sant’Agnese PA, de Mesy Jensen KL (1987) Neuroendocrine differentiation in prostatic adenocarcinoma. Hum Pathol 18: 849–856
di Sant’Agnese PA, de Mesy Jensen KL, Churukian CJ, Agarwal MM (1985) Human prostatic endocrine-paracrine (APUD) cells. Distributional analysis with a comparison of serotonin and neuron-specific enolase immunoreactivity and silver stains. Arch Pathol Lab Med 109: 607–612
Eggleston JC, Walsh PC (1985) Radical prostatectomy with preservation of sexual function: pathologic findings in the first 100 cases. J Urol 134: 1146–1148
Elgamal AA, Van de Voorde W, Van Poppel H, Lauweryns J, Baert L (1994a) Immunohistochemical localization of prostate-specific markers within accessory male sex glands of Cowper, Littré and Morgagni. Urology 44: 84–90
Elgamal AA, Van de Voorde W, Van Poppel H, Vandeursen H, Baert L, Lauweryns J (1994b) Exophytic papillary prostatic duct adenocarcinoma with endometrioid features, occurring in prostatic urethra after TURP. Urology 43: 737–742
Epstein JI (1990) Evaluation of radical prostatectomy capsular margins of resection: the significance of margins designated as negative, closely approaching, and positive. Am J Surg Pathol 14: 626–632
Epstein JI (1991) The evaluation of radical prostatectomy specimens. Therapeutic and prognostic implications. Pathol Annu 26: 159–210
Epstein JI (1992) Differential diagnosis in pathology. Urologic disorders. Igaku-Shoin, New York, pp 108–109
Epstein JI (1993) Discrepancies between findings suspicious for prostate cancer at rectal examination and benign biopsy findings. Radiology 189: 657–658
Epstein JI (1995) Diagnostic criteria of limited adenocarcinoma of the prostate on needle biopsy. Hum Pathol 26: 223–229
Epstein JI, Lieberman PH (1985) Mucinous adenocarcinoma of the prostate gland. Am J Surg Pathol 9: 299–308
Epstein JI, Carmichael M, Partin AW, Walsh PC (1993a) Is tumor volume an independent predictor of progression following radical prostatectomy? A multivariate analysis of 185 clinical stage B adenocarcinomas of the prostate with five years follow-up. J Urol 149: 1478–1481
Epstein JI, Carmichael M, Pizov G et al. (1993b) Influence of capsular penetration on progression following radical prostatectomy: a study of 196 cases with long-term follow-up. J Urol 150: 135–141
Epstein JI, Pizov G, Walsh PC (1993c) Correlation of pathologic findings with progression after radical retropubic prostatectomy. Cancer 71: 3582–3593
Fair WR, Aprikian A, Sogani P, Reuter V, Whitmore WF (1993) The role of neoadjuvant hormonal manipulation in localized prostate cancer. Cancer 71 (Suppl): 1031–1038
Gaudin PB, Epstein JI (1994) Adenosis of the prostate. Histologic features in transurethral resection specimens. Am J Surg Pathol 18: 863–870
Gleason DF (1990) Histologic grading of prostatic carcinoma. In: Bostwick DG (ed) Pathology of the prostate. Churchill Livingstone, New York, pp 83–93
Gleason DF, Mellinger GT, Vacurg (1974) Prediction of prognosis for prostatic carcinoma by combined histological grading and clinical staging. J Urol 111: 58–64
Greene DR, Wheeler TM, Egawa S, Dunn JK, Scardino PT (1991) A comparison of the morphological features of cancer arising in the transition zone and in the peripheral zone of the prostate. J Urol 146: 1069–1076
Greene DR, Fitzpatrick JM, Scardino PT (1995) Anatomy of the prostate and distribution of early prostate cancer. Semin Surg Oncol 11: 9–22
Guerin D, Hasan N, Keen CE (1993) Signet ring cell differentiation in adenocarcinoma of the prostate: a study of five cases. Histopathology 22: 367–371
Hall GS, Kramer CE, Epstein JI (1992) Evaluation of radical prostatectomy specimens. A comparative analysis of sampling methods. Am J Surg Pathol 16: 315–324
Harper ME, Glynne-Jones E, Goddard L et al. (1992) Relationship of proliferating cell nuclear antigen (PCNA) in prostatic carcinomas to various clinical parameters. Prostate 20: 243–253
Hedrick L, Epstein JI (1989) Use of keratin 903 as an adjunct in the diagnosis of prostate carcinoma. Am J Surg Pathol 13: 389–396
Helpap B (1985) Treated prostatic carcinoma. Histological, immunohistochemical and cell kinetic studies. Appl Pathol 3: 230–241
Hollstein M, Sidransky D, Vogelstein B, Harris C (1991) p53 mutations in human cancer. Science 253:49–53
Huggins C, Hodges CV (1941) Studies on prostatic cancer. The effect of castration, of estrogen and of androgen injection on serum phosphatases in metastatic carcinoma of the prostate. Cancer Res 1: 293–297
Humphrey PA, Frazier HA, Vollmer RT, Paulson DF (1993) Stratification of pathologic features in radical prostatectomy specimens that are predictive of elevated initial postoperative serum prostate-specific antigen levels. Cancer 71: 1821–1827
Isaacs JT, Coffey DS (1984) Adaptation versus selection as the mechanism responsible for relapse of prostate cancer to androgen ablation therapy as studied in the Dunning R-3327-H adenocarcinoma. Cancer Res 41: 5070–5075
Ittmann M, Wieczorek R, Heller P, Dave A, Provet J, Krolewski J (1994) Alterations in the p53 and MDM-2 genes are infrequent in clinically localized, stage B prostate adenocarcinomas. Am J Pathol 145: 287–293
Jones EC, Young RH (1994) The differential diagnosis of pro-static carcinoma. Its distinction from premalignant and pseudocarcinomatous lesions of the prostate gland. Am J Clin Pathol 101: 48–64
Kadmon D, Thompson TC, Lynch GR, Scardino PT (1991) Elevated plasma chromogranin-A concentrations in prostatic carcinoma. J Urol 146: 358–361
Kallakury BVS, Frigge J, Ross JS, Fisher HAG, Figge HL, Jennings TA (1994) Association of p53 immunoreactivity with high Gleason tumor grade in prostatic adenocarcinoma. Hum Pathol 25: 92–97
Kellokumpu-Lehtinen P, Santti R, Pelliriemi LJ (1980) Correlation of early cytodifferentiation of the human prostate and Leydig cells. Anat Res 196: 262–273
Klocker H, Culig Z, Hobisch A, Cato ACB, Bartsch G (1994) Androgen receptor alterations in prostatic carcinoma. Prostate 25: 266–273
Lane DP (1994) The regulation of p53 function: Steiner Award Lecture. Int J Cancer 57: 623–627
Larsen WJ (1993) Development of the urogenital system. In: Larsen WJ (ed) Human embryology. Churchill Livingstone, New York, pp 235–279
Lepor H, Gregerman M, Crosby R, Mostofi FK, Walsh PC (1985) Precise localization of the autonomic nerves from the pelvic plexus to the corpora cavernosa: a detailed anatomical study of the adult male pelvis. J Urol 133: 207–212
Loda M, Fogt F, French FS, Posner M, Cukor B, Aretz HT, Alsaigh N (1994) Androgen receptor immunohistochemistry on paraffin-embedded tissue. Mod Pathol 7: 388–391
Masai M, Sumiya H, Akimoto S, Yatani R, Chang C, Liao S, Shimazaki J (1990) Immunohistochemical study of androgen receptor in benign hyperplastic and cancerous human prostates. Prostate 17: 293–300
Matzkin H, Soloway MS, Hardeman S (1991) Transitional cell carcinoma of the prostate. J Urol 146: 1207–1212
McNeal JE (1980) Anatomy of the prostate: an historical survey of divergent views. Prostate 1: 3–13
McNeal JE (1983) The prostate gland. Morphology and pathobiology. Monogr Urol 4: 3–33
McNeal JE (1988a) Normal histology of the prostate. Am J Surg Pathol 12: 619–633
McNeal JE (1988b) Significance of duct-acinar dysplasia in prostatic carcinogenesis. Prostate 13: 91–102
McNeal JE (1992) Cancer volume and site of origin of adenocarcinoma in the prostate: relationship to local and distant spread. Hum Pathol 23: 258–266
McNeal JE, Bostwick DG (1986) Intraductal dysplasia: a premalignant lesion of the prostate. Hum Pathol 17: 64–71
McNeal JE, Bostwick DG, Kindrachuk RA, Redwine EA, Freiha ES, Stamey TA (1986) Patterns of progression in prostate cancer. Lancet 1: 60–63
McNeal JE, Price HM, Redwine EA, Freiha FS, Stamey TA (1988a) Stage A versus stage B adenocarcinoma of the prostate: morphological comparison and histological significance. J Urol 139: 61–65
McNeal JE, Redwine EA, Freiha FS, Stamey TA (1988b) Zonal distribution of prostatic adenocarcinoma. Correlation with histologic pattern and direction of spread. Am J Surg Pathol 12: 897–906
McNeal JE, Villers AA, Redwine EA, Freiha FS, Stamey TA (1990) Capsular penetration in prostate cancer. Significance for natural history and treatment Am J Surg Pathol 14: 240–247
McNeal JE, Alroy J, Villers A, Redwine EA, Freiha FS, Stamey TA (1991) Mucinous differentiation in prostatic adenocarcinoma. Hum Pathol 22: 979–988
Montie JE, Wood DP Jr, Vanderburg Medendorp S, Levin HS, Pontes JE (1990) The significance and management of transitional cell carcinoma of the prostate. Semin Urol 8: 262–268
Montironi R, Magi-Galluzzi C, Muzzonigro G, Prete E, Polito M, Fabris G (1994) Effects of combination endocrine treatment on normal prostate, prostatic intraepithelial neoplasia, and prostatic adenocarcinoma. J Clin Pathol 47: 906–913
Mostofi FK, Price EB Jr (1973) Tumors of male genital system (Fascicle 8). Atlas of tumor pathology, 2nd series. Armed Forces Institute of Pathology, Washington DC, pp 236–338
Mostofi FK, Sesterhenn I, Sobin LH (1980) Histologic typing of prostate tumours. (International histological classification of tumours, no. 22). WHO, Geneva
Murphy GP, Busch C, Abrahamsson P-A et al. (1994) Histopathology of localized prostate cancer. Scand J Urol Nephrol Suppl 162: 7–42
Myers RP (1991a) Anatomical variation of the superficial preprostatic veins with respect to radical retropublic prostatectomy. J Urol 145: 992–993
Myers RP (1991b) Male urethral sphincteric anatomy and radical prostatectomy. Urol Clin North Am 18: 211–227
Myers RP, Goellner JR, Cahill DR (1987) Prostate shape, external striated urethral sphincter and radical prostatectomy: the apical dissection. J Urol 138: 543–550
Myers RB, Oelschlager D, Srivastave S, Grizzle WE (1994) Accumulation of the p53 protein occurs more frequently in metastatic than in localized prostatic adenocarcinomas. Prostate 25: 243–248
Navone NM, Troncoso P, Pisters LL et al. (1993) p53 protein accumulation and gene mutation in the progression of human prostate carcinoma. J Natl Cancer Inst 85:1657–1669
Oesterling JE, Hauzeur CG, Farrow GM (1992) Small cell ana-plastic carcinoma of the prostate: a clinical, pathological and immunohistological study of 27 patients. J Urol 147: 804–807
Ohori M, Scardino PT, Lapin SL, Seale-Hawkins C, Link J, Wheeler TM (1993) The mechanisms and prognostic significance of seminal vesicle involvement by prostate cancer. Am J Surg Pathol 17: 1252–1261
Pearse AGE (1969) The cytochemistry and ultrastructure of polypeptide hormone-producing cells of the APUD series and the embryologic, physiologic and pathologic implications of the concept. J Histochem Cytochem 17: 303–313
Reese JH, Freiha FS, Gelb AB, Lum BL, Torti FM (1992) Transitional cell carcinoma of the prostate in patients undergoing radical cystoprostatectomy. J Urol 147: 92–95
Reichlin S (1993) Neuroendocrine-immune interactions. N Engl J Med 329: 1246–1253
Ro JY, Tetu B, Ayala AG, Ordonez NG (1987) Small cell carcinoma of the prostate. II. Immunohistochemical and electron microscopic studies of 18 cases. Cancer 59: 977–982
Ro JY, Ayala AG, Wishnow KI, Ordonez NG (1988a) Prostatic duct adenocarcinoma with endometrioid features: immunohistochemical and electron microscopic study. Semin Diagn Pathol 5: 301–311
Ro JY, Grignon DJ, Troncoso P, Ayala AG (1988b) Mucin in prostatic adenocarcinoma. Semin Diagn Pathol 5: 273–283
Ro JY, Grignon DJ, Ayala AG, Fernandez PL, Ordonez NG, Wishnow KI (1990) Mucinous adenocarcinoma of the prostate: histochemical and immunohistochemical studies. Hum Pathol 21: 593–600
Ruizeveld de Winter JA, Trapman J, Brinkmann AO et al. (1990) Androgen receptor heterogeneity in human prostatic carcinomas visualized by immunohistochemistry. J Pathol 161: 329–332
Sadi MV, Barrack ER (1993) Image analysis of androgen receptor immunostaining in metastatic prostate cancer-heterogeneity as a predictor of response to hormonal therapy. Cancer 71: 2574–2580
Sadi MV, Walsh PC, Barrack ER (1991) Immunohistochemical study of androgen receptors in metastatic prostate cancer. Comparison of receptor content and response to hormonal therapy. Cancer 67: 3057–3064
Schmid H-P, McNeal JE (1992) An abbreviated standard procedure for accurate tumor volume estimation in prostate cancer. Am J Surg Pathol 16: 184–191
Schröder FH, Hermanek P, Denis L et al. (1992) The TNM classification of prostate cancer. Prostate 4 (Suppl): 129–138
Schröder F, Tribukait B, Böcking A et al. (1994) Clinical utility of cellular DNA measurements in prostate carcinoma. Scand J Urol Nephrol Suppl 162: 51–64
Scott WW, Menon M, Walsh PC (1980) Hormonal therapy of prostatic cancer. Cancer 45 (Suppl): 1929–1936
Siiteri PK, Wilson JD (1974) Testosterone formation and metabolism during male sexual differentiation in the human embryo. J Clin Endocrinol Metab 38: 113–125
Smith DM, Murphy WM (1994) Histologic changes in prostate carcinomas treated with leuprolide (Iuteinizing hormone-releasing hormone effect). Distinction from poor tumor differentiation. Cancer 73: 1472–1477
Sogani P, Israel A, Lieberman P et al. (1985) Gleason grading of prostatic cancer: a predictor of survival. Urology 25: 223–227
Spires SE, Banks ER, Davey DD, Jennings CD, Wood DP, Cibull ML (1994) Proliferating cell nuclear antigen in prostatic adenocarcinoma: correlation with established prognostic indicators. Urology 43: 660–666
Stamey TA, Vang H, Hay AR, McNeal JE, Freiha FS, Redwine EA (1987) Prostate-specific antigen as a serum marker for adenocarcinoma of the prostate. N Engl J Med 317: 909–916
Tarie M, Frkovic-Grazio S, Kraljic I, Kovacic K (1994) A more objective staging of advanced prostate cancer–routine recognition of malignant endocrine structures: the assessment of serum TPS, PSA, and NSE values. Prostate 24: 143–148
Thomas DJ, Robinson M, King P et al. (1993) p53 expression and clinical outcome in prostate cancer. Br J Urol 72:778–781
Thompson SJ, Mellen K, Charlton RG, Marsh C, Robinson M, Neal DE (1992) p53 and Ki-67 immunoreactivity in human prostate cancer and benign hyperplasia. Br J Urol 69:609–613
Ullrich SJ, Anderson CW, Mercer WE et al. (1992) The p53 tumor suppressor protein, a modulator of cell proliferation. J Biol Chem 267: 15259–15262
Van der Kwast TH, Schaller J, Ruizenveld de Winter JA, Van Vroonhoven CCJ, Mulder E, Boersma W, Trapman J (1991) Androgen receptors in endocrine therapy-resistant human prostate cancer. Int J Cancer 48: 189–193
Van de Voorde WM, Baldewijns M, Lauweryns JM (1994a) Florid basal cell hyperplasia of the prostate. Histopathology 24: 341–348
Van de Voorde WM, Elgamal AA, Van Poppel HP, Verbeken EK, Baert LV, Lauweryns JM (1994b) Morphologic and immunohistochemical changes in prostate cancer after preoperative hormonal therapy. A comparative study of radical prostatectomies. Cancer 74: 3164–3175
Van de Voorde WM, Van Poppel HP, Haustermans K, Baert LV, Lauweryns JM (1994c) Mucin-secreting adenocarcinoma of the prostate with neuroendocrine differentiation and Paneth-like cells. Am J Surg Pathol 18: 200–207
Van de Voorde WM, Oyen RH, Van Poppel HP, Wouters K, Baert LV, Lauweryns JM (1995a) Peripherally localized benign hyperplastic nodules of the prostate. Mod Pathol 8: 46–50
Van de Voorde WM, Van Poppel HP, Verbeken EK, Oyen RH, Baert LV, Lauweryns JM (1995b) Morphologic and neuroendocrine features of adenocarcinoma arising in the transition zone and in the peripheral zone of the prostate. Mod Pathol 8: 595–598
Van Poppel HP, Ameye F, Oyen R, Van de Voorde WM, Baert LV (1992) Radical prostatectomy for localized prostate cancer. Eur J Surg Oncol 18: 456–462
Van Poppel HP, Ameye F, Oyen RH, Van de Voorde WM, Baert LV (1994) Accuracy of combined computerized tomography and fine needle aspiration cytology in lymph node staging of localized prostatic carcinoma. J Urol 151: 1310–1314
Vesalainen S, Lipponen P, Talja M, Syrjänen K (1995) Mitotic activity and prognosis in prostatic adenocarcinoma. Prostate 26: 80–86
Villers A, McNeal JE, Redwine EA, Freiha FS, Stamey TA (1989) The role of perineural space invasion in the local spread of prostatic adenocarcinoma. J Urol 142: 763–768
Vogelstein B, Kinzler KW (1992) p53 function and dysfunction. Cell 70:523–526
Voges GE, McNeal JE, Redwine EA, Freiha FS, Stamey TA (1992) Morphological analysis of surgical margins with positive findings in prostatectomy for adenocarcinoma of the prostate. Cancer 65: 520–526
Walsh PC, Lepor H, Eggleston JC (1983) Radical prostatectomy with preservation of sexual function: anatomical and pathological considerations. Prostate 4: 473–485
Ware JL (1994) Prostate cancer progression. Implications of histopathology. Am J Pathol 145: 983–993
Weinstein MH, Epstein JI (1993) Significance of high-grade prostatic intraepithelial neoplasia on needle biopsy. Hum Pathol 24: 624–629
Wojno KJ, Epstein JI (1995) The utility of basal cell-specific anti-cytokeratin antibody (34ßE12) in the diagnosis of prostate cancer. A review of 228 cases. Am J Surg Pathol 19: 251–260
Wood DP Jr, Montie JE, Pontes JE, Vanderburg Medendorp S, Levin HS (1989) Transitional cell carcinoma of the prostate in cystoprostatectomy specimens removed for bladder cancer. J Urol 141: 346–349
Xia T, Blackburn WR, Gardner WA (1990) Fetal prostate growth and development. Pediatr Pathol 10: 527–537
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Van De Voorde, W.M. (1996). Pathology of Prostatic Carcinoma. In: Petrovich, Z., Baert, L., Brady, L.W. (eds) Carcinoma of the Prostate. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60956-5_4
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