Abstract
More than 85 years have elapsed since, in 1910, the German physician Carl Muller first described the potential for using hyperthermia (HT) as a new adjuvant to radiotherapy (RT) in the management of patients with advanced malignant neoplasms. In empiric studies of the first 100 patients with superficial tumors, Muller used high-frequency electromagnetic fields generated by a medical diathermy apparatus (Muller 1912). Despite poor control of his HT parameters during these early clinical trials, a significant improvement of the expected radiation effect in HT-treated patients was noted.
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Szmigielski, S. et al. (1996). Hyperthermia for Carcinoma of the Prostate. In: Petrovich, Z., Baert, L., Brady, L.W. (eds) Carcinoma of the Prostate. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60956-5_23
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DOI: https://doi.org/10.1007/978-3-642-60956-5_23
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