Skip to main content

The Autonomic Nervous System: Peripheral and Central Integrative Aspects

  • Chapter
Comprehensive Human Physiology

Abstract

Regulation of the internal environment (milieu intérieur) of the body was recognized by Claude Bernard as the essential condition for “free and independent life.” The tendency for processes to maintain a steady state in the body led Cannon to coin the term “homeostasis” (see Chap. 2). Cannon further proposed that the autonomic nervous system (particularly the sympathetic division; see below) played an important role in the maintenance of homeostasis, through its action on tissues of the body [12]. The autonomic nervous system itself was described around the beginning of the twentieth century, principally by Gaskell and Langley and their co-workers. The term “autonomic nervous system” was first used by Langley in 1898, and writing in 1921 [49] he states that ‘the word “autonomic” does suggest a much greater degree of independence of the central nervous system than in fact exists.’ Indeed, it has long been realized that the autonomic nervous system is under the regulation of centers in the brain, notably the hypothalamus. As defined, the autonomic nervous system is a motor system.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 349.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 449.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

General References

  • Appenzeller O (1990) The autonomic nervous system, 4th edn. Elsevier, New York

    Google Scholar 

  • Bannister R (ed) (1988) Autonomic failure, 2nd edn. Oxford University Press, New York

    Google Scholar 

  • Berntson GG, Cacioppo JT, Quigley KS (1991) Autonomic determinism: the modes of autonomic control, the doctrine of autonomic space, and the laws of autonomic constraint. Psychol Rev 98:459–487

    Article  PubMed  CAS  Google Scholar 

  • Björklund A, Hökfelt T, Owman C (eds) (1988) The peripheral nervous system. Elsevier, Amsterdam (Handbook of chemical neuroanatomy, vol 6)

    Google Scholar 

  • Cannon WB (1932) The wisdom of the body. Norton, New York

    Google Scholar 

  • Cervero F, Morrison JFB (eds) (1986) Visceral sensation. Elsevier, Amsterdam (Progress in brain research, vol 67)

    Google Scholar 

  • Ciriello J, Calaresu FR, Renaud LP, Polosa C (eds) (1987) Organisation of the autonomic nervous system: central and peripheral mechanisms. Liss, New York

    Google Scholar 

  • Elfvin L-G (ed) (1983) Autonomic ganglia. Wiley, Chichester

    Google Scholar 

  • Ermisch R, Landgraf R, Ruhle HJ (eds) (1992) Circumventricular organs and brain fluid environment. Molecular and functional aspects. Elsevier, Amsterdam (Progress in brain research, vol 91)

    Google Scholar 

  • Furness JB, Costa M (1987) The enteric nervous system. Churchill Livingstone, Edinburgh

    Google Scholar 

  • Goetzl EJ, Spector NH (eds) (1989) Neuroimmune networks: physiology and disease. Liss, New York

    Google Scholar 

  • Hökfelt T, Fuxe K, Pernow B (eds) (1986) Coexistence of neuronal messengers: a new principle in chemical transmission. Elsevier, Amsterdam (Progress in brain research, vol 68)

    Google Scholar 

  • Jänig W, McLachlan EM (1992) Characteristics of function-specific pathways in the sympathetic nervous system. Trends Neurosci 15:475–481

    Article  PubMed  Google Scholar 

  • Langley JN (1921) The autonomic nervous system. Heffer, Cambridge

    Google Scholar 

  • Loewy AD, Spyer KM (eds) (1990) Central regulation of autonomic functions. Oxford University Press, New York

    Google Scholar 

  • Roth well NJ (1991) Autonomic and central control of thermogenesis. In: Rothwell NJ, Stock MJ (eds) Obesity and cachexia. Wiley, London, pp 13–34

    Google Scholar 

  • Singer MV, Goebell H (eds) (1989) Nerves and the gastrointestinal tract. MTP Press, Lancaster (Falk symposium, vol 50)

    Google Scholar 

Specific References

  1. Ader R, Felten D, Cohen N (1990) Interactions between the brain and the immune system. Annu Rev Pharmacol Toxicol 30:561–602

    Article  PubMed  CAS  Google Scholar 

  2. Altschuler SM, Rinaman L, Miselis RR (1992) Viscerotopic representation of the alimentary tract in the dorsal and ventral vagal complexes in the rat. In: Ritter S, Ritter RC, Barnes CD (eds) Neuroanatomy and physiology of abdominal vagal afferents. CRC Press, Boca Raton, pp 21–54

    Google Scholar 

  3. Barde Y-A (1989) Trophic factors and neuronal survival. Neuron 2:1525–1534

    Article  PubMed  CAS  Google Scholar 

  4. Barnes PJ (1990) Neurogenic inflammation in airways and its modulation. Arch Int Pharmacodyn 303:67–82

    PubMed  CAS  Google Scholar 

  5. Basbaum AI, Levine JD (1991) The contribution of the nervous system to inflammation and inflammatory disease. Can J Physiol Pharmacol 69:647–651

    Article  PubMed  CAS  Google Scholar 

  6. Bornstein JC, Furness JB (1988) Correlated electrophysiological and histochemical studies of submucous neurons and their contribution to understanding enteric neural circuits. J Auton Nerv Syst 25:1–13

    Article  PubMed  CAS  Google Scholar 

  7. Bornstein JC, Furness JB (1992) Enteric neurons and their chemical coding. In: Holle GE, Wood JD (eds) Advances in the innervation of the gastrointestinal tract. Excerpta Medica, Amsterdam, pp 101–114 (International congress series, vol 1008)

    Google Scholar 

  8. Burnett AL, Lowenstein CJ, Bredt DS, Chang TSK, Snyder SH (1992) Nitric oxide: a physiologic mediator of penile erection. Science 257:401–403

    Article  PubMed  CAS  Google Scholar 

  9. Burnstock G (1990) Co-transmission. Arch Int Pharmacodyn 304:7–33

    PubMed  CAS  Google Scholar 

  10. Cabot JB (1990) Sympathetic preganglionic neurons: cytoarchitecture, ultrastructure and biophysical properties. In: Loewy AD, Spyer KM (eds) Central regulation of autonomic functions. Oxford University Press, New York, pp 44–67

    Google Scholar 

  11. Calaresu FR, Yardley CP (1988) Medullary basal sympathetic tone. Annu Rev Physiol 50:511–542

    Article  PubMed  CAS  Google Scholar 

  12. Cannon WB (1932) The wisdom of the body. Norton, New York

    Google Scholar 

  13. Castro G (1989) Gut immunophysiology: regulatory pathways within a common mucosa immune system. News Physiol Sci 4:59–64

    Google Scholar 

  14. Cechetto DF, Saper CB (1990) Role of the cerebral cortex in autonomic function. In: Loewy AD, Spyer KM (eds) Central regulation of autonomic functions. Oxford University Press, New York, pp 208–223

    Google Scholar 

  15. Cervero F, Connell LA, Lawson SN (1984) Somatic and visceral primary afferents in the lower thoracic dorsal root ganglia of the cat. J Comp Neurol 228:422–431

    Article  PubMed  CAS  Google Scholar 

  16. Cervero F, Foreman RD (1990) Sensory innervation of viscera. In: Loewy AD, Spyer KM (eds) Central regulation of autonomic functions. Oxford University Press, New York, pp 104–125

    Google Scholar 

  17. Cervero F, Jänig W (1992) Visceral nociceptors: a new world order. Trends Neurosci 15:374–378.

    Article  PubMed  CAS  Google Scholar 

  18. Costa M, Brookes S, Waterman S, Mayo R (1992) Enteric neuronal circuitry and transmitters controlling intestinal motor function. In: Holle GE, Wood JD (eds) Advances in the innervation of the gastrointestinal tract. Excerpta Medica, Amsterdam, pp 115–145 (International congress series, vol 1008)

    Google Scholar 

  19. Dantzer R (1989) L’illusion psychomatic. Editions Odile Jacob, Paris

    Google Scholar 

  20. Dantzer R, Kelley KW (1989) Stress and immunity: an integrated view of the relationships between the brain and the immune system. Life Sci 44:1995–2008

    Article  PubMed  CAS  Google Scholar 

  21. Davison JS (1983) Innervation of the gastrointestinal tract. In: Christensen J, Wingate DL (eds) A guide to gastrointestinal motility. Wright, Bristol, pp 1–47

    Google Scholar 

  22. Davison JS (1992) Central organization of gastrointestinal vagal reflexes. In: Thomson ABR, Shaffer E (eds) Modern concepts in gastroenterology, vol 3. Plenum, New York, pp 129–144

    Chapter  Google Scholar 

  23. de Groat (1986) Spinal cord projections of visceral afferent neurons. In: Cervero F, Morrison JFB (eds) Visceral sensation. Elsevier, New York, pp 165–188 (Progress in brain research, vol 67)

    Chapter  Google Scholar 

  24. de Groat WC, Nadelhaft I, Milne RJ, Booth AM, Morgan C, Thor K (1981) Organisation of the parasympathetic reflex pathways to the urinary bladder and large intestine. J Auton Nerv Syst 3:135–160

    Article  PubMed  Google Scholar 

  25. Disturnal J, Veale WL, Pittman QJ (1986) The ventral septal area: electrophysiological evidence for putative arginine vasopressin projections onto thermoresponsive neurons. Neurosci 19: 795–802

    Article  CAS  Google Scholar 

  26. Dockray GJ, Sharkey KA (1986) Neurochemistry of visceral afferent neurons. In: Cervero F, Morrison JFB (eds) Visceral sensation. Elsevier, New York, pp 133–148 (Progress in brain research, vol 67)

    Chapter  Google Scholar 

  27. Dodd J, Role LW (1991) The autonomic nervous system. In: Kandel ER, Schwartz JH, Jessell TM (eds) Principles of neural science, 3rd edn. Elsevier, New York, pp 761–775

    Google Scholar 

  28. Dubner R, Ruda MA (1992) Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci 15:96–103

    Article  PubMed  CAS  Google Scholar 

  29. Felten DL, Felten SY, Bellinger DL, Carlson SL, Ackerman KD, Madden KS, Olschowski JA, Livnat S (1987) Noradrenergic sympathetic neural interactions with the immune system: structure and function. Immunol Rev 100:225–260

    Article  PubMed  CAS  Google Scholar 

  30. Ferguson AV (1992) Neurophysiological analysis of mechanisms for subfornical organ and area postrema involvement in autonomic control. Prog Brain Res 91:413–421

    Article  PubMed  CAS  Google Scholar 

  31. Furness JB, Costa M (1987) The enteric nervous system. Churchill Livingstone, Edinburgh

    Google Scholar 

  32. Furness JB, Bornstein JC, Murphy R, Pompolo S (1992) Roles of peptides in transmission in the enteric nervous system. Trends Neurosci 15:66–71

    Article  PubMed  CAS  Google Scholar 

  33. Furness JB, Morris JL, Gibbins IL, Costa M (1989) Chemical coding of neurons and plurichemical transmission. Annu Rev Pharmacol Toxicol 29:289–306

    Article  PubMed  CAS  Google Scholar 

  34. Gebber GL, Barman SM, Kocsis B (1990) Coherence of medullary unit activity and sympathetic nerve discharge. Am J Physiol 259:R561–R571

    PubMed  CAS  Google Scholar 

  35. Hayes K, Weaver LC (1990) Selective control of sympathetic pathways to the kidney, spleen and intestine by the ventrolateral medulla in rats. J Physiol (Lond) 486:371–385

    Google Scholar 

  36. Hirst GD, Bramich NJ, Edwards FR, Klemm M (1992) Transmission at autonomic neuroeffector junctions. Trends Neurosci 15:40–46

    Article  PubMed  CAS  Google Scholar 

  37. Hökfelt T (1991) Neuropeptides in perspective: the last ten years. Neuron 7:867–879

    Article  PubMed  Google Scholar 

  38. Holzer P (1988) Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides. Neuroscience 24:739–768

    Article  PubMed  CAS  Google Scholar 

  39. Jan YN, Jan LY (1983) A LHRH-like peptidergic neurotransmitter capable of “action at a distance” in autonomic ganglia. Trends Neurosci 6:320–325

    Article  Google Scholar 

  40. Jänig W (1990) The sympathetic nervous system in pain: physiology and pathophysiology. In: Stanton-Hicks M (ed) Pain and the sympathetic nervous system. Kluwer, Boston, pp 17–90

    Google Scholar 

  41. Jänig W, McLachlan EM (1987) Organization of lumbar spinal outflow to distal colon and pelvic organs. Physiol Rev 67:1332–1404

    PubMed  Google Scholar 

  42. Jänig W, McLachlan EM (1992) Characteristics of function-specific pathways in the sympathetic nervous system. Trends Neurosci 15:475–481

    Article  PubMed  Google Scholar 

  43. Jhamandas JH, Aippersbach SV, Harris KH (1992) Cardiovascular influences on rat parabrachial nucleus: an electrophysiological study. Am J Physiol 260:R225–R231

    Google Scholar 

  44. Koizumi K, Kollai M (1981) Control of reciprocal action of vagal and sympathetic efferents: study of centrally induced reactions. J Auton Nerv Syst 3:483–501

    Article  PubMed  CAS  Google Scholar 

  45. Koizumi K, Kollai M (1992) Multiple modes of operation of cardiac autonomic control: development of the ideas from Cannon and Brooks to the present. J Auton Nerv Syst 41:19–30

    Article  PubMed  CAS  Google Scholar 

  46. Korsching S (1993) The neurotrophic factor concept: a reexamination. J Neurosci 13: 2739–2748

    PubMed  CAS  Google Scholar 

  47. Krukoff TL (1990) Neuropeptide regulation of autonomic outflow at the sympathetic preganglionic neuron. Ann NY Acad Sci 579:160–167

    Article  PubMed  CAS  Google Scholar 

  48. Langley JN (1903) The autonomic nervous system. Brain 26:1–26

    Article  Google Scholar 

  49. Langley JN (1921) The autonomic nervous system. Heffer and Sons, Cambridge

    Google Scholar 

  50. Lundberg JM (1990) Peptide and classical transmitter mechanisms in the autonomic nervous system. Arch Int Pharmacodyn 303:9–19

    PubMed  CAS  Google Scholar 

  51. Lundberg JM, Rudehill A, Sollevi A, Fried G, Wallin G (1989) Co-release of neuropeptide Y and noradrenaline from pig spleen in vivo: importance of subcellular storage nerve impulse frequency and pattern, feedback regulation and resupply by axonal transport. Neuroscience 28:475–486

    Article  PubMed  CAS  Google Scholar 

  52. Malliani A (1982) Cardiovascular sympathetic afferent fibers. Rev Physiol Biochem Pharmacol 94:11–74

    Article  Google Scholar 

  53. Mattews MR, Cuello AC (1984) The origin and possible significance of substance P immunoreactive networks in the prevertebral ganglia and related structures in the guineapig. Philos Trans R Soc Lond 306:247–276

    Article  Google Scholar 

  54. Matsuo R, Yamamoto T (1989) Gustatory-salivary reflex: neural activity of sympathetic and parasympathetic fibers innervating the submandibular gland of the hamster. J Auton Nerv Syst 26:187–197

    Article  PubMed  CAS  Google Scholar 

  55. McMahon SB (1991) Mechanisms of sympathetic pain. Br Med Bull 47:584–600

    PubMed  CAS  Google Scholar 

  56. Monda M, Pittman QJ (1993) Cortical spreading depression blocks prostaglandin El and endotoxin fever in rats. Am J Physiol 264:R456–R459

    PubMed  CAS  Google Scholar 

  57. Morgan JI, Curran T (1989) Stimulus-transcription coupling in neurons: role of cellular immediate-early genes. Trends Neurosci 12:459–462

    Article  PubMed  CAS  Google Scholar 

  58. Nichols K, Staines W, Krantis A (1994) Nitric oxide synthase distribution in the rat intestine: a histochemical analysis. Gastroenterology 105:1651–1661

    Google Scholar 

  59. North RA (1986) Mechanisms of autonomic integration. In: Mountcastle VB, Bloom FE (eds) The nervous system, Intrinsic regulatory systems of the brain. Oxford University Press, New York, pp 115–153 (Handbook of physiology, section 1, vol IV)

    Google Scholar 

  60. Parkinson D (1990) Adrenergic receptors in the autonomic nervous system. In: Loewy AD, Spyer KM (eds) Central regulation of autonomic functions. Oxford University Press, New York, pp 17–27

    Google Scholar 

  61. Parkinson D (1990) Cholinergic receptors. In: Loewy AD, Spyer KM (eds) Central regulation of autonomic functions. Oxford University Press, New York, pp 28–43

    Google Scholar 

  62. Parr EJ, Davison SN, Davison JS, Sharkey KA (1993) The origin of neurons with projections passing through the inferior mesenteric ganglion of the guinea pig. J Auton Nerv Syst 44:91–99

    Article  PubMed  CAS  Google Scholar 

  63. Pittman QJ (1991) Hypothalamus. In: Dulbecco R (ed) The encyclopedia of human biology, vol 4. Academic, New York, pp 303–313

    Google Scholar 

  64. Pittman QJ, Blume HW, Renaud LP (1981) Connections of the hypothalamic paraventricular nucleus with the neurohypophysis, median eminence, amygdala, lateral septum and midbrain periaqueductal gray: an electrophysiological study in the rat. Brain Res 215:15–28

    Article  PubMed  CAS  Google Scholar 

  65. Powley TL, Berthoud HR, Fox EA, Laughton W (1992) The dorsal vagal complex forms a sensory-motor lattice: the circuitry of gastrointestinal reflexes. In: Ritter S, Ritter RC, Barnes CD (eds) Neuroanatomy and physiology of abdominal vagal afferents. CRC Press, Boca Raton, pp 55–80

    Google Scholar 

  66. Prechtl JC, Powley TL (1990) B-afferents: a fundamental division of the nervous system mediating homeostasis? Behav Brain Sci 13:289–331

    Article  Google Scholar 

  67. Purves D, Snider WD, Voyvodic T (1988) Trophic regulation of nerve cell morphology and innervation in the autonomic nervous system. Nature 336:123–128

    Article  PubMed  CAS  Google Scholar 

  68. Renaud LP, Tang M, McCann MJ, Strieker EM, Verbalis JG (1987) Cholecystokinin and gastric distention activate oxytocinergic cells in rat hypothalamus. Am J Physiol 253:R661–R665

    PubMed  CAS  Google Scholar 

  69. Saito M, Akiyoshi M, Shimizu Y (1991) Possible role of the sympathetic nervous system in response to interleukin-1. Brain Res Bull 27:305–308

    Article  PubMed  CAS  Google Scholar 

  70. Sanders KM, Ward SM (1992) Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am J Physiol 262:G379–G392

    PubMed  CAS  Google Scholar 

  71. Saper CB, Loewy AD, Swanson LW, Cowan WM (1976) Direct hypothalamo-autonomic connections. Brain Res 117:305–312

    Article  PubMed  CAS  Google Scholar 

  72. Sharkey KA (1992) Substance P and calcitonin gene-related peptide (CGRP) in gastrointestinal inflammation. Ann NY Acad Sci 664:425–442

    Article  PubMed  CAS  Google Scholar 

  73. Shiraishi T (1987) Gastric related properties of rat paraventricular neurons. Brain Res Bull 18:315–323

    Article  PubMed  CAS  Google Scholar 

  74. Smith OA, DeVito JL (1984) Central neural integration for the control of autonomic responses associated with emotion. Annu Rev Neurosci 7:43–65

    Article  PubMed  CAS  Google Scholar 

  75. Spyer KM (1989) Neural mechanisms involved in cardiovascular control during affective behavior. Trends Neurosci 12:506–513

    Article  PubMed  CAS  Google Scholar 

  76. Stead RH, Perdue MH, Blennerhassett MG, Kakuta Y, Sestini P, Bienenstock J (1990) The innervation of mast cells. In: Freier S (ed) Neuroendocrine-immune network. CRC Press, Boca Raton, pp 19–37

    Google Scholar 

  77. Szurszewski JH, King BF (1989) Physiology of prevertebral ganglia in mammals with special reference to inferior mesenteric ganglion. In: Schultz SG, Wood JD (eds) The gastrointestinal system, Motility and Circulation. Oxford University Press, New York, pp 519–592 (Handbook of physiology, section 6, vol I)

    Google Scholar 

  78. Torres G, Bitran M, Huidobro-Toro JP (1992) Co-release of neuropeptide Y (NPY) and noradrenaline from the sympathetic nerve terminals supplying the rat vas deferens; influence of calcium and stimulation intensity. Neurosci Lett 148:39–42

    Article  PubMed  CAS  Google Scholar 

  79. Weiner N, Taylor P (1985) Neurohumoral transmission: the autonomic and somatic motor nervous systems. In: Goodman Gilman A, Goodman LS, Rail TW, Murad F (eds) The pharmacological basis of therapeutics, 7th edn. Macmillan, New York, pp 66–99

    Google Scholar 

  80. Wood JD (1987) Physiology of the enteric nervous system. In: Johnson LR (ed) Physiology of the gastrointestinal tract, 2nd edn. Raven, New York, pp 67–109

    Google Scholar 

  81. Wood JD (1992) Gastrointestinal neuroimmune interactions. In: Holle GE, Wood JD (eds) Advances in the innervation of the gastrointestinal tract. Excerpta Medica, Amsterdam, pp 607–618 (International congress series, vol 1008)

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Sharkey, K.A., Pittman, Q.J. (1996). The Autonomic Nervous System: Peripheral and Central Integrative Aspects. In: Greger, R., Windhorst, U. (eds) Comprehensive Human Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60946-6_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60946-6_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64619-5

  • Online ISBN: 978-3-642-60946-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics