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Comprehensive Human Physiology pp 267–282Cite as

Ion Channels in Excitable Membranes

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Abstract

Excitability. Excitability of cell membranes is crucial for signaling in many types of cell. Excitation in the physiological sense means that the cell membrane potential undergoes characteristic changes which, in most cases, go in the depolarizing direction. Single depolarization from the resting potential to potentials near 0 mV has generally been called an action potential. A schematic representation of a neuronal action potential is given in Fig. 12.1 A. The action potential is triggered when the membrane potential, which was at the resting level, depolarizes and reaches the threshold of excitation. This depolarization, which triggers the action potential, is generated by depolarizing synaptic currents, or depolarizing current coming from a membrane region that is already excited (propagation of an action potential), or by pacemaker currents mediated by pacemaker channels, or by current injected externally by an electrode. The duration of different types of action potential varies from seconds to less than 1 ms.

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Authors
  1. J. P. Ruppersberg
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Editors and Affiliations

  1. Physiologisches Institut, Universität Freiburg, Hermann-Herder-Str. 7, 79104, Freiburg, Germany

    Rainer Greger

  2. Faculty of Medicine, Department of Clinical Neurosciences, University of Calgary, 3330 Hospital Drive N.W., T2N 4N1, Calgary, Alberta, Canada

    Uwe Windhorst

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© 1996 Springer-Verlag Berlin Heidelberg

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Ruppersberg, J.P. (1996). Ion Channels in Excitable Membranes. In: Greger, R., Windhorst, U. (eds) Comprehensive Human Physiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60946-6_13

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  • DOI: https://doi.org/10.1007/978-3-642-60946-6_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64619-5

  • Online ISBN: 978-3-642-60946-6

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