Skip to main content
SpringerLink
Log in
Book cover

Thermoradiotherapy and Thermochemotherapy pp 349–360Cite as

Prognostic Factors in Thermoradiotherapy Clinical Trials

  • Chapter

  • 50 Accesses

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

Abstract

Despite the extensive clinical experience accumulated over the past decade and the large amount of data available in the current literature, the optimal regimen of combined hyperthermia and radiotherapy is not yet known (Meyer et al. 1989; Overgaard 1989; Sugahara and Saito 1989). Because of easier heat delivery and temperature monitoring, superficial hyperthermia has been more popular than interstitial or deep hyperthermia and has allowed a number of treatment combinations with radiotherapy, depending on a series of factors that may vary in different clinical situations.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arcangeli G, Yabumoto E (1989) Prognostic factors in the combined treatment of tumors. In:Sugahara T, Saito M (eds) Hyperthermic Oncology 1988, vol 2. Taylor & Francis, London, p 609

    Google Scholar 

  • Arcangeli G, Nervi C, Cividalli A, Lovisolo G (1984) Problem of sequence and fractionation in the clinical application of combined heat and radiation. Cancer Res 44:4857s–4863s

    PubMed  CAS  Google Scholar 

  • Arcangeli G, Arcangeli GC, Guerra A, Lovisolo G, Cividalli A, Marino C, Mauro F (1985) Tumour response to heat and radiation:prognostic variables in the treatment of neck node metastases from head and neck cancer. Int J Hyperthermia 3:207–217

    Article  Google Scholar 

  • Arcangeli G, Benassi M (1987) Factors and variables affecting tumor response to combined heat and radiation in head and neck. Strahlen Therapie und Onkologie 163(7):425–427

    CAS  Google Scholar 

  • Arcangeli G, Benassi M, Cividalli A, Lovisolo G, Mauro F (1987) Radiotherapy and hyperthermia:analysis of clinical results and identification of prognostic variables. Cancer 60:950–956

    Article  PubMed  CAS  Google Scholar 

  • Arcangeli G, Casale C, Colistro F, Benassi M, Lovisolo G, Begnozzi L (1991) One versus four heat treatments in combination with radiotherapy in metastatic mammary carcinoma. Int J Radiat Oncol Biol Phys 21:1569–1574

    Article  PubMed  CAS  Google Scholar 

  • Dewhirst MW, Sim DA (1984) The utility of thermal dose as a predictor of tumor and normal tissue response to combined radiation and hyperthermia. Cancer Res 44:4772s–4780s

    PubMed  CAS  Google Scholar 

  • Emami B, Perez CA, Konefal J, et al. (1988) Thermo-radiotherapy of malignant melanoma. Int J Hyperthermia 4:373–381

    Article  PubMed  CAS  Google Scholar 

  • Field SB (1987) Studies relevant to a means of quantifying the effects of hyperthermia. Int J Hyperthermia 3:291–296

    Article  Google Scholar 

  • Gonzales Gonzales D, van Dijk JDP, Blank LECM, Rumke P (1986) Combined treatment with radiation and hyperthermia in metastatic melanoma. Radiother Oncol 6:105–113

    Article  Google Scholar 

  • Gonzales Gonzales D, van Dijk JDP, Blank LECM (1988) Chest wall recurrences of breast cancer:results of com-bined treatment with radiation and hyperthermia. Radiother Oncol 12:95–103

    Article  Google Scholar 

  • Hill SA, Denekamp J (1979) The response of six mouse tumours to combined heat and X-rays:implications for therapy. Br J Radiol 52:209–218

    Article  PubMed  CAS  Google Scholar 

  • Hofman P, Lagendjik JJW, Schipper J (1984) The combination of radiotherapy with hyperthermia in protocol- ized clinical studies. In:Overgaard J (ed) Hyperthermic Oncology 1984, vol 1. Taylor & Francis, London, p 379

    Google Scholar 

  • Kapp DS, Petersen IA, Cox RS, et al. (1990) Two or six hyperthermia treatments as an adjunct to radiation therapy yield similar tumor responses:results of a randomized trial. Int J Radiat Oncol Biol Phys 19:1481–1495

    Article  PubMed  CAS  Google Scholar 

  • Kim JH, Hahn EW, Ahmed SA (1982) Combination hyperthermia and radiation therapy for malignant melanomas,. Cancer 50:478–482

    Article  PubMed  CAS  Google Scholar 

  • Kim JH, Hahn EW, Ahmed SA, Kim YS (1984) Clinical study of the sequence of combined hyperthermia and radiation therapy of malignant melanoma. In:Overgaard J (ed) Hyperthermic Oncology 1984, vol 1. Taylor & Francis, London, p 387

    Google Scholar 

  • Komarnichy L, Engin K, Tupchong L, et al. (1992) Randomized trial of one-weekly vs twice-weekly hyperthermia treatments in thermoradiotherapy of superficial tumors. In:Gerner EW (ed) Hyperthermic Oncology 1992, vol 1. Taylor & Francis, London, p 373

    Google Scholar 

  • Leopold KA, Harrelson JM, Prosnitz LR, Samulski TV, Dewhirst MW, Oleson JR (1989) Preoperative hyperthermia and radiation for soft tissue sarcomas:advantages of two vs one hyperthermia treatments per week. Int J Radiat Oncol Biol Phys 16:107–115

    Article  PubMed  CAS  Google Scholar 

  • Leopold KA, Dewhirst MW, Samulski TV, et al. (1992) Relationship among tumor temperature, treatment time and histopathological outcome using preoperative hyperthermia with radiation in soft tissue sarcomas. Int J Radiat Oncol Biol Phys 22:989–998

    Article  PubMed  CAS  Google Scholar 

  • Lindholm CE, Kjellen E, Nilson P (1992) A randomized trial on one versus two hyperthermia sessions per week combined with low-dose radiotherapy in superficial malignant tumors. In:Gerner EW (ed) Hyperthermic Oncology 1992, vol 1. Taylor & Francis, London, p 372

    Google Scholar 

  • Luk KH, Pajak TF, Perez CA, Johnson RJ, Corner N, Dobbins T (1984) Prognostic factors for tumor response after hyperthermia and radiation. In:Overgaard J (ed) Hyperthermic Oncology 1984, vol 1. Taylor & Francis, London, p 353

    Google Scholar 

  • Marino C, Cividalli A (1992) Combined radiation and hyperthermia:effects of the number of heat fractions and their interval on normal and tumor tissues. Int J Hyperthermia 8:771–781

    Article  PubMed  CAS  Google Scholar 

  • Meyer JL, Van Kersen I, Hahn GM (1986) Tumor re-sponses following multiple hyperthermia and X-ray treatments:role of thermotolerance at the cellular level. Cancer Res 46:5691–5695

    PubMed  CAS  Google Scholar 

  • Meyer JL, Kapp DS, Fessenden P, Hahn GM (1989) Hyperthermic oncology:current biology, physics and clinical results. Pharmacol Ther 42:251–258

    Article  PubMed  CAS  Google Scholar 

  • Myerson RJ, Perez CA, Emami B, Straube WS, Kuske RR, Leybovich LB, von Gerichten D (1990) Tumor control in long-term survivors following superficial hyperthermia,. Int J Radiat Oncol Biol Phys 18:1123–1129

    Article  PubMed  CAS  Google Scholar 

  • Oleson JR, Sim DA, Manning MR (1984) Analysis of prognostic variables in hyperthermia treatment of 161 patients,. Int J Radiat Oncol Biol Phys 10:2231–2239

    Article  PubMed  CAS  Google Scholar 

  • Oleson JR, Dewhirst MW, Harrelson JM, Leopold KA, Samulski TV, Tso CY (1989) Tumor temperature distributions predict hyperthermia effect. Int J Radiat Oncol Biol Phys 16:559–570

    Article  PubMed  CAS  Google Scholar 

  • Oleson JR, Leopold KA, Samulski TV, et al. (1990) Results of a phase II trial of HT + RT. Proceedings of the 38th annual meeting of the Radiation Research Society, New Orleans, abstract no. Ak-8

    Google Scholar 

  • Oleson JR, Samulski TV, Leopold KA, Clegg ST, Dewhirst MW, Dodge RK, George SL (1993) Sensitivity of hyperthermia trial outcomes to temperature and time:implications for thermal goals of treatment. Int J Radiat Oncol Biol Phys 25:289–297

    Article  PubMed  CAS  Google Scholar 

  • Overgaard J (1980) Simultaneous and sequential hyperthermia and radiation treatment of an experimental tumor and its surrounding normal tissue in vivo,. Int J Radiat Oncol Biol Phys 6:1507–1517

    PubMed  CAS  Google Scholar 

  • Overgaard J (1989) The current and potential role of hyperthermia in radiotherapy. Int J Radiat Oncol Biol Phys 16:535–549

    Article  PubMed  CAS  Google Scholar 

  • Overgaard J, Overgaard M (1987) Hyperthermia as an adjunct to radiotherapy in the treatment of malignant melanoma. Int J Hyperthermia 3:483–501

    Article  PubMed  CAS  Google Scholar 

  • Overgaard J, Gonzales Gonzales D, Hulshof MCCM, Arcangeli G, Dahl O, Hella O, Bentzen SM (1995) Randomised trial of hyperthermia as adjuvant to radiotherapy for recurrent or metastetic malignant melanoma. The Lencet 345:540–543

    Article  CAS  Google Scholar 

  • Perez CA, Kuske RR, Emami B, Fineberg B (1986) Irradiation alone or combined with hyperthermia in the treatment of recurrent carcinoma of the breast in the chest wall. A nonrandomized comparison,. Int J Hyperther 2:179–187

    Article  CAS  Google Scholar 

  • Perez CA, Emami B, Hederman MA, Straube W, von Gerichten D, Fox S (1987) Clinical results of irradiation combined with local hyperthermia in superficial tumors. Proceedings of the 35th annual meeting of the Radiation Research Society, Atlanta, p 18

    Google Scholar 

  • Perez CA, Pajak T, Emami B, Hornback NB, Tupchong L, Rubin P (1991) Randomized phase III study com¬paring irradiation and hyperthermia with irradiation alone in superficial measurable tumors. Am J Clin Oncol 14:133–141

    Article  PubMed  CAS  Google Scholar 

  • Sapareto SA (1987) Thermal isoeffect dose:addressing the problem of thermotolerance. Int J Hyperthermia 3:297–307

    Article  PubMed  CAS  Google Scholar 

  • Scott R, Gillespie B, Perez CA, et al. (1988) Hyperthermia in combination with definitive radiation therapy:results of a phase I/II RTOG study. Int J Radiat Oncol Biol Phys 15:711–716

    Article  PubMed  CAS  Google Scholar 

  • Sugahara T, Saito M (1989) Hyperthermic oncology 1988,vols 1, 2. Taylor & Francis, London

    Google Scholar 

  • Valdagni R, Kapp DS, Valdagni C (1986) N3 (TNM- UICC) metastatic neck nodes managed by combined radiation therapy and hyperthermia:clinical results and analysis of treatment parameters. Int J Hyperthermia 2:189–200

    Article  PubMed  CAS  Google Scholar 

  • Valdagni R, Liu FF, Kapp DS (1988a) Important prognostic factors influencing outcome of combined radiation and hyperthermia. Int J Radiat Oncol Biol Phys 15:959–972

    Article  CAS  Google Scholar 

  • Valdagni R, Amichetti M, Pani G (1988b) Radical radiation alone versus radical radiation plus microwave hyperthermia for N3 (TNM-UICC) neck nodes:a prospective randomized clinical trial,. Int J Radiat Oncol Biol Phys 15:13–24

    CAS  Google Scholar 

  • van der Zee J, van Putten WLJ, van den Berg AP, van Rhoon GC, Hooley JLW, Broekmeyer-Reurink MP, Reinhold HS (1986) Retrospective analysis of the response of tumors in patients treated with a combination of radio¬therapy and hyperthermia. Int J Hyperthermia 2:337–349

    Article  PubMed  Google Scholar 

  • Zywietz F, Jung H (1990) Response of the R1H tumor to fractionated radiotherapy and hyperthermia:dependence on number and application period of heat treatments. Strahlenther Oncol 8:540–541

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. G. Porfiri Oncology Center, Radiation Oncology Department, S. Maria Goretti Hospital, Via G. Reni, I-04100, Latina, Italy

    G. Arcangeli MD & G. Giovinazzo MD

Authors
  1. G. Arcangeli MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. Giovinazzo MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Arcangeli, G., Giovinazzo, G. (1996). Prognostic Factors in Thermoradiotherapy Clinical Trials. In: Thermoradiotherapy and Thermochemotherapy. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60938-1_20

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60938-1_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64613-3

  • Online ISBN: 978-3-642-60938-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation