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5-HT Receptors Involved in the Regulation of Hormone Secretion

  • Chapter
Serotoninergic Neurons and 5-HT Receptors in the CNS

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 129))

Abstract

The hypothalamus, particularly the paraventricular nucleus (PVN), plays a central role in coordinating and regulating neuroendocrine function. Axons from cells originating in the PVN release corticotropin-releasing hormone (CRH) into the hypophysial portal vessels. CRH is then transported to the anterior pituitary gland, where it controls the release of corticotropin (adrenocorticotropic hormone, ACTH), leading to increased secretion of adrenal glucocorticoids (cortisol in humans, corticosterone in rats) (Swanson and Sawchenk 1983; Sawchenk Swanson 1985). Activation of other cells in the PVN increases prolactin release from the anterior lobe of the pituitary gland (Bagdy and Makara 1994, 1995; Bluet Pajot et al. 1995; Rittenhouse et al. 1993; Arey and Freeman 1992: Minamitani et al. 1987; Kiss et al. 1986). Cells in the PVN and supraoptic nucleus (SON) that synthesize oxytocin and vasopressin release these peptides into the circulation from their nerve terminals in the posterior (neural) lobe of the pituitary gland (Swanson and Sawchenko 1983). Finally, cells in the PVN are also important in the regulation of renin release from the kidneys (Rittenhouse et al. 1992b; Richardson Morton et al. 1989).

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  1. L. D. Van De Kar
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  1. Freie Universität Berlin, Institut für Anatomie, Königin-Luise-Str. 15, 14195, Berlin, Germany

    H. G. Baumgarten M.D.

  2. Rheinische Friedrich-Wilhelms-Universität Bonn, Institut für Pharmakologie und Toxikologie, Reuterstr. 2b, 53113, Bonn, Germany

    M. Göthert

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Van De Kar, L.D. (2000). 5-HT Receptors Involved in the Regulation of Hormone Secretion. In: Baumgarten, H.G., Göthert, M. (eds) Serotoninergic Neurons and 5-HT Receptors in the CNS. Handbook of Experimental Pharmacology, vol 129. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60921-3_20

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