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5-HT4 Receptors: An Update

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Book cover Serotoninergic Neurons and 5-HT Receptors in the CNS

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 129))

Abstract

Shenker et al. (1987) showed, in guinea pig hippocampal membranes, that stimulation of adenylyl cyclase (AC) by 5-hydroxytryptamine (5-HT) involves two receptors: the 5-HT (RH) receptor, which displays a high affinity for 5-HT, is characterized as a 5-HT1A-like receptor and is now recognized as a 5-HT7 receptor (Hoyer et al. 1994), and the 5-HT (RL) receptor, which has a low affinity for 5-HT and which has not been identified. A clear biphasic doseactivation curve was obtained only with 5-carboxamidotryptamine (5-CT). Indeed, this agonist had high (13nM) and low (3000 nM) affinities for 5-HT (RH) and 5-HT (RL) receptors, respectively.

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  1. J. Bockaert
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  2. L. Fagni
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  3. A. Dumuis
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Editors and Affiliations

  1. Freie Universität Berlin, Institut für Anatomie, Königin-Luise-Str. 15, 14195, Berlin, Germany

    H. G. Baumgarten M.D.

  2. Rheinische Friedrich-Wilhelms-Universität Bonn, Institut für Pharmakologie und Toxikologie, Reuterstr. 2b, 53113, Bonn, Germany

    M. Göthert

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Bockaert, J., Fagni, L., Dumuis, A. (2000). 5-HT4 Receptors: An Update. In: Baumgarten, H.G., Göthert, M. (eds) Serotoninergic Neurons and 5-HT Receptors in the CNS. Handbook of Experimental Pharmacology, vol 129. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60921-3_17

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