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Behavioral Consequences of 5-HT1B Receptor Gene Deletion

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Serotoninergic Neurons and 5-HT Receptors in the CNS

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 129))

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a biogenic amine which is involved in a wide range of physiological functions including sleep, appetite, pain perception, sexual activity, memory and mood control (for a review see Wilkinson et al. 1991). A central serotonin deficit has been associated with behaviors such as suicidality, impulsive violence (Higley et al. 1992), depression and alcoholism (Eichelmann et al. 1992), and serotoninergic drugs are used in the treatment of a number of pathological states including migraine, depression and anxiety (Sleight et al. 1991). The multiple actions of serotonin are mediated by the interaction of this amine with at least 14 receptors (for a review see Saudou and Hen 1994), most of which belong to the G-proteincoupled receptor family.

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Authors and Affiliations

  1. Institut de Génétique et de Biologie Moléculaire et Cellulaire du CNRS-LGME, U184 de I’INSERM, Parc d’Innovation, B.P.-163, F-67404, Illkirch Cedex, France

    N. Castanon, S. Ramboz, F. Saudou & R. Hen

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  1. N. Castanon
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  2. S. Ramboz
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  3. F. Saudou
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  4. R. Hen
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Editors and Affiliations

  1. Freie Universität Berlin, Institut für Anatomie, Königin-Luise-Str. 15, 14195, Berlin, Germany

    H. G. Baumgarten M.D.

  2. Rheinische Friedrich-Wilhelms-Universität Bonn, Institut für Pharmakologie und Toxikologie, Reuterstr. 2b, 53113, Bonn, Germany

    M. Göthert

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© 2000 Springer-Verlag Berlin Heidelberg

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Castanon, N., Ramboz, S., Saudou, F., Hen, R. (2000). Behavioral Consequences of 5-HT1B Receptor Gene Deletion. In: Baumgarten, H.G., Göthert, M. (eds) Serotoninergic Neurons and 5-HT Receptors in the CNS. Handbook of Experimental Pharmacology, vol 129. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60921-3_13

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  • DOI: https://doi.org/10.1007/978-3-642-60921-3_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-66715-5

  • Online ISBN: 978-3-642-60921-3

  • eBook Packages: Springer Book Archive

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