Abstract
Leborgne, in 1951, was the first to point out that microcalcifications occur in 30% of breast carcinomas. He wrote: “With sufficient experience differential diagnosis between calcifications of maligant processes … and … in benign processes is generally easy.” Egan (1964) also asserted: “The typical calcifications are pathognomonic of carcinoma. They are so specific, that in their presence, a histological diagnosis of benign disease usually indicates that either the surgeon has selected the wrong tissue for biopsy, or that the pathologist is in error.” However, analysis of 23 articles on microcalcifications published between 1964 and 1994 shows that cancer was detected in only 27.5% of 5481 cases operated on for microcalcifications (Table 7.1). Similar results can be found in studies carried out by Rosen et al. (1974), Tinnemans et al. (1986), and Abbes et al. (1988), which yielded figures of 24%, 28.3%, and 29%, respectively.
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References
Abbes M, Vergnet F, Aubanel D (1988) Practical importance of breast microcalcifications: report on 112 cases. Eur J Surg Oncol 14:651–661
Azzopardi JG (1979) Problems in breast pathology. Saunders, Philadelphia
Basset LW, Gold RH, Cove HC (1978) Mammographic spectrum of traumatic fat necrosis: the fallibility of “pathognomic” signs of carcinoma. Am J Roentgenol 130:119
Basset LW, Gold RH, Mirra JM (1982) Nonneoplastic breast calcifications in lipid cysts: development after excision and primary irradiation AJR 138:335–338
Bässler R (1978) Pathologie der Brustdrüse (Spezielle pathologische Anatomie, vol 11). Springer, Berlin, Heidelberg, New York
Bauermeister DE, McClure H, Hall DA (1973) Specimen radiography - a mandatory adjunct to mammography. Am J Clin Pathol 59:782–789
Beute BJ, Kalisher L, Hutter RVP (1991) Lobular carcinoma in situ of the breast: clinical, pathologic and mammographic features. AJR 157:257–265
Bjurstam NG (1978) Radiography of the female breast and axilla. Acta Radiol Suppl 357
Bloodgood JC (1934) Comedocarcinoma (or comedoadenoma of the female breast). Am J Cancer 22:842
Britton CA, Sumkin J, Math M, Williams S (1992) Mammographic appearance of loiasis. AJR 159:51–52
Brown RC, Zuehlke RL, Ehrhardt JC, Jochimsen PR (1981) Tattoos simulating calcifications on xeroradiographs of the breast. Radiology 138:583
Bruwer A, Nelson GW, Spark RP (1987) Punctate intranodal gold deposits simulating microcalcifications on mammograms. Radiology 163:87–88
Bryant J (1981) Male breast cancer: a case of apocrine carcinoma with psammoma bodies. Hum Pathol 12:751
Ciatto S, Bianchi S, Vezzosi V (1994) Mammographic appearance of calcifications as a predictor of intraductal carcinoma histologic subtype. Eur Radiol 4:23–26
Citoler P (1978) Microcalcifications of the breast in early diagnosis of breast cancer. In: Grundmann E, Beck L (eds) Cancer campaign, vol 1. Gustav Fischer, Stuttgart, pp 113–118
Colbassini HJ, Feller WF, Cigtay OS, Chun B (1982) Mammographic and pathologic correlation of microcalcification in disease. Surg Gynecol Obstet 155:689–696
Davis SP, Stomper PC, Weidner N, Meyer JE (1989) Suture calcification mimicking recurrence in the irradiated breast: a potential pitfall in mammographic evaluation. Radiology 172:247–248
de Lafontan B, Daures JP, Salicru B et al. (1994) Isolated clustered microcalcifications: diagnostic value of mammography - series of 400 cases with surgical verification. Radiology 190:479–483
Egan RL (1964) Mammography. Thomas, Springfield, Illinois
Egan RL (1988) Breast imaging. Saunders, Philadelphia
Egan RL, McSweeney MB, Sewell CW (1980) Intramammary calcifications without an associated mass in benign and malignant diseases. Radiology 137:1–7
Foote FW, Stewart FW (1945) Comparative studies of cancerous versus non cancerous breasts. Am Surg 121:6
Galkin BM, Feig SA, Frasca P, Muir HD, Soriano RZ (1983) Photomicrographs of breast calcifications: correlation with histopathologic diagnosis. Radiographics 3:450–477
Gershon-Cohen J (1970) Atlas of mammography. Springer, Berlin, Heidelberg, New York
Gershon-Cohen J, Ingleby H, Hermel MB (1956) Calcification in secretory disease of the breast. AJR 76:132–135
Gershon-Cohen J, Yiu LS, Berger SM (1962) The diagnostic importance of calcareous patterns in roentgenography of breast cancer. Radiology 88:1117–1125
Gershon-Cohen J, Berger SM, Curcio BM (1966) Breast cancer with microcalcifications: diagnostic difficulties. Radiology 87:613–622
Gilles R, Lesnik A, Guinebrotjere JM, Tardivon A, Masselot J, Contosso C, Vanel D (1994) Apocrine carcinoma: clinical and mammographic features. Radiology 190: 495–497
Hamperl H (1939) Über die Myothelien (Myoepithelialen Elemente) der Brustdrüse. Virchows Arch (A) 305:171
Hamperl H (1968) Lehrbuch der allgemeinen Pathologie and pathologischen Anatomie Springer, Berlin, Heidelberg, New York
Hassler O (1969) Microradiographic investigations of calcifications of the female breast. Cancer 23:1103–1109
Helvie MA, Rebner M, Sickles EA, Oberman HA (1988) Calcifications in metastatic breast carcinoma in axillary lymph nodes. AJR 151:921–922
Helvie MA, Hessler C, Frank TS, Ikeda DM (1991) Atypical hyperplasia of the breast: mammographic appearance and histologic correlation. Radiology 179:759–764
Hoeffken WM, Lanyi M (1973) Mammography. Thieme, Stuttgart
Holland R, Hendriks JHCL (1994) Microcalcifications associated with ductal carcinoma in situ: mammographicpathologic correlation. Semin Diagn Pathol 11:181–192
Holland R, Hendriks JHCL, Verteek ALM et al. (1990) Extent distribution and mammographic/histological correlations of breast ductal carcinoma in situ. Lancet 335:483–485
Homer MJ (1984) The mammography report. AJR 142:643–644
Homer MJ, Cooper AG, Pile-Spellman ER (1988) Milk of calcium in breast microcysts: manifestation as a solitary focal disease. AJR 150:789–790
Homer MJ, D’Orsi CJ, Sitzman SB (1994) Dermal calcifications in fixed orientation: the tattoo sign. Radiology 192:161–163
Hutter RVP, Snyder RE, Lucas JC, Foote FW, Farrow JH (1969) Clinical and pathologic correlation with mammographic findings in lobular carcinoma in situ. Cancer 23:826–839
Ikeda DM, Sickles EA (1988) Mammographic demonstration of pectoral muscle microcalcifications. AJR 151:475–476
Ingleby H, Gershon-Cohen J (1960) Comparative anatomy pathology and roentgenology of the breast. University of Pennsylvania Press, Philadelphia
Ingleby H, Hermel MB (1956) Calcification in secretory disease of the breast. Am J Roentgenol 76:132
Inoue Y, Ohya G, Maruyama M, Omoto R (1978) Die röntgenologischen Ver-änderungen nach Mammaplastik. Fortschr Roentgenstr 129:353
Kersschot E, Achten E, Hoste M et al. (1985) Microcalcifications: differential diagnostic limits. In: Colin C, Gordenne W (eds) Evaluation du risque de cancer mammaire, chimiotherapie premiere? Brussels, pp 69–79
Kindermann G, Rummel W, Bischoff J, Paterok E, Weishaar J, Willgeroth F, Ober KG (1979) Early detection of ductal breast cancer: the diagnostic procedure for grouped microcalcification. Tumori 65:547–553
Koide T, Katayama H (1979) Calcification in augmentation mammoplasty. Radiology 130:337
Kopans DB, Nguyen PI, Koerner FG et al. (1990) Mixed form, diffusely scattered calcifications in breast cancer with apocrine features. Radiology 177:807–811
Lanyi M (1977) Differentialdiagnose der Mikroverkalkungen. Die verkalkte mastopathische Mikrozyste. Radiologe 17:217–218
Lanyi M (1982) Formanalyse von 153 Mikroverkalkungen maligner Genese. Das “Dreieckprinzip”. Fortschr Roentgenstr 136:77
Lanyi M (1983) Formanalyse von 5641 Mikroverkalkungen bei 100 Milchgangs-karzinomen: Die Polymorphie. Fortschr Roentgenstr 139:240
Lanyi M (1985) Microcalcifications in the breast - a blessing or a curse? A critical review. Diagn Imag Clin Med 54:126–145
Lanyi M (1986) Diagnosis and differential diagnosis of breast calcifications. Springer, Berlin, Heidelberg, New York
Lanyi M, Citoler P (1981) Differentialdiagnostik der Mikroverkalkungen: Die kleinzystische (blunt duct) Adenose. Fortschr Roentgenstr 134:225
Lanyi M, Neufang KFR (1984) Möglichkeiten und Grenzen der Differentialdiagnostik gruppierter intramammärer Mikroverkalkungen. Fortschr Roentgenstr 141:4
Leborgne R (1951) Diagnosis of tumors of the breast by simple roentgenography AJR 65:1–11
Leborgne R (1967) Esteatonecrosis quistica calcificata de la mama. Torax 16:172
Le Gal M, Durand JC, Laurent M, Pellier D (1976) Conduite a tenir devant une mammographie revelatrice de microcalcifications groupees, sans tumeur palpable. La Nouvelle Presse medicale 5:1623–1627
Le Gal M, Chavanne G, Pellier D (1984) Valeur diagnostique des microcalcifications groupees decouvertes par mammographies. (A propos de 227 cas avec verification histologique et sans tumeur du sein palpable). Bull Cancer (Paris) 71:57–64
Le Treut A, Barreau B, Kind M, Dilhuydy MH (1992) Les microcalcifications mammaires. J Radiol 73:527–541
Levitan H, Witten DM, Harrison EG (1964) Calcification in breast disease mammographic-pathologic correlation. AJR 92:29–39
Lewison EF (1964) Lobular carcinoma in situ of the breast. Mil Med 129:115
Libshitz HI, Montagne ED, Paulus DD (1977) Calcifications and the therapeutically irradiated breast. AJR 128:1021–1025
Linden SS, Sickles EA (1989) Sedimented calcium in benign breast cysts: the full spectrum of mammographic presentations. AJR 152:967–971
Linden SS, Sullivan DC (1989) Breast skin calcifications: localization with a stereotactic device. Radiology 171:570–571
MacErlean DP, Nathan BE (1972) Calcification in sclerosing adenosis simulating malignant breast calcification. Br J Radiol 45:944–945
Marinesen I, Damian A (1984) Primary hyperparathyreoidism associated with galactophorous ducts calcification. Endokrinologie 22:211
Martin JE, Moskowitz M, Milbrath JR (1979) Breast cancer missed by mammography. AJR 132:737–739
Menges V, Wellauer J, Engeler V, Stadelmann R (1973) Korrelation zahlenmäßig erfaßter Mikroverkalkungen auf dem Mammogramm und dadurch diagnos-tizierter Carcinome und Mastopathietypen. Radiologe 13:468–476
Menges V, Frank P, Prager P (1976) Zahlenmäßige Zunahme von Mikroverkalkungen, ein wichtiges röntgendiagnostisches Kriterium für das okkulte Mammakarzinom. Fortschr Röntgenstr 124:372–378
Millis RR, Davies R, Stacey AJ (1976) The detection and significance of calcifications in the breast: a radiological and pathological study. Br J Radiol 49:12–26
Mirowitz SA, Kotner LM (1988) Metastatic breast cancer presenting as micro-calcifications in axillary lymph nodes. J Med Imaging 2:16–18
Mitnick JS, Roses DF, Harris MN, Feiner HD (1989) Circumscribed intra-ductal carcinoma of the breast. Radiology 170:423–425
Moskowitz M (1979) Screening is not diagnosis. Radiology 133:265–258
Muir BB, Lamb J, Anderson TJ, Kirkpatrick AE (1983) Micro-calcification and its relationship to cancer of the breast: experience in a screening clinic. Clin Radiol 34:193–200
Murphy WA, De Schryver-Kecskemeti K (1978) Isolated clustered microcalcification in the breast: radiologicpathologic correlation. Radiology 127:335–341
Parker MD, Clark RL, McLelland R, Daughtery K (1989) Disappearing breast calcifications. Radiology 172:677–680
Paterok EM, Rosenthal H, Richter S, Säbel M (1993) Occult calcified breast lesions. Eur Radiol 3:138–144
Péntek Z, Balogh J, Bakó B, Éliás S (1975) Mikrokalzifikation im männlichen Mammakarzinom. Fortschr Röntgenstr 123:90–91
Pope TL, Fechner RE, Wilhelm MC, Wanebo HJ, de Paredes WS (1988) Lobular carcinoma in situ of the breast: mammographic features. Radiology 168:63–66
Powell RW, McSweeney MB, Wilson CE (1983) X-ray calcifications as the only basis for breast biopsy. Ann Surg 197:555–559
Prorok JJ, Trostle DR, Scarlato M, Rachman R (1983) Excisional breast biopsy and roentgenographic examination for mammographically detected microcalcification. Am J Surg 145:684–686
Rebner M, Raju U (1994) Noninvasive breast cancer. Radiology 190:623–631
Rocek V, Sery Z, Sera D, Kamenicek O (1968) Verkalkungen beim männlichen Mammakarzinom. Fortschr Roentgenstr 109:679
Rogers JV, Powell RW (1972) Mammographic indications for biopsy of clinically normal breasts: correlation with pathologic findings in 72 cases. AJR 115:794–800
Roselli del Turco M, Ciatto S, Bravetti P, Pacini P (1986) The significance of mammographic calcifications in early breast cancer detection. Radiol Med (Torino) 72:7–12
Rosen IW, Nadel HI (1966) Roentgenographic demonstration of calcification in carcinoma of the male breast. Radiology 86:38
Rosen PP (1984) Lobular carcinoma in situ and intraductal carcinoma of the breast. In: McDivitt RW, Obermann HA, Ozello L, Kaufmann N (eds) The breast. International Academy of Pathology monograph. Williams and Wilkins, Baltimore
Rosen PP, Snyder RE, Robbins G (1974) Specimen radiography for nonpalpable breast lesions found by mammography: procedures and results. Cancer 34:2028–2033
Roses DF, Harris MN, Gorstein F, Gumport SL (1980) Biopsy for micro-calcification detected by mammography. Surgery 87:248–252
Sang Y Han, Witten DM (1977) Diffuse calcification of the breast in chronic renal failure. Am J Roentgenol 129:341–342
Schnitt SJ, Connolly JL, Tavassoli FA, Fechner RE, Kempson RL, Gelman R, Page DL (1992) Interobserver reproducibility in the diagnosis of ductal proliferative breast lesions using standardized criteria. Am J Surg Pathol 16:1133–1143
Schwartz GF, Feig SA, Rosenberg AL, Paterefsky AS, Schwartz AB (1984) Staging and treatment of clinically occult cancer. Cancer 53:1379
Sickles EA (1980) Further experience with microfocal spot magnification mammography in the assessment of clustered breast microcalcifications. Radiology 137:9–14
Sickles EA (1984) Mammographic features of “early” breast cancer. AIR 143:461–464
Sickles EA (1986) Breast calcifications: mammographic evaluation. Radiology 160:289–293
Sickles EA, Abele JS (1981) Milk of calcium within tiny benign breast cysts. Radiology 141:655–658
Sigfusson BF, Andersson I, Ljungberg O (1982) Percutaneous injection of contrast medium into breast lesions for radiographic exclusion of malignancy. Br J Radiol 55: 26–31
Sigfusson BF, Andersson I, Aspegren K, Janzon L, Linell F, Ljungberg O (1983) Clustered breast calcifications. Acta Radiol 24:273–281
Snyder RE (1966) Mammography and lobular carcinoma in situ. Surg Gynecol Obstet ••:255–260
Sonnenfeld MR, Frenna TH, Weidner N, Meyer JE (1991) Lobular carcinoma in situ: mammographic-pathologic correlation of results of needle-directed biopsy. Radiology 181:363–367
Stacey-Clear A, McCarthy KA, Hall DA et al. (1992) Calcified suture material in the breast after radiation therapy. Radiology 183:207–208
Stomper PC, Connolly JL (1992) Ductal carcinoma in situ of the breast: correlation between mammographic calcification and tumor subtype. AJR 159:483–485
Tabár L, Marton L, Kádas I (1972) Verkalkungen im männlichen Brustkrebs. Fortschr Roentgenstr 117:360–362
Thiels C, Dumke K (1977) Mammaverkalkung nach Paraffininjektion. Fortschr Roentgenstr 126:173
Tinnemans JGM, Wobbes T, Lubbers EJC, van der Sluis RF, de Boer HHM (1986) The significance of microcalcifications without palpable mass in the diagnosis of breast cancer. Surgery 99:652–657
Urban JA, Adair FE (1949) Sclerosing adenosis. Cancer 2: 625
Wahlers B, Plum R, Fischedick O (1977) Die perkutane Darstellung von Milchgängen in gutartigen Mammatumoren. Fortschr Roentgenstr 126:345–350
Willemin A (1972) Les images mammographiques. Karger, Basel
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Lanyi, M. (2000). Differential Diagnosis of Microcalcifications. In: Friedrich, M., Sickles, E.A. (eds) Radiological Diagnosis of Breast Diseases. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60919-0_7
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