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Virologic and immunologic events in primary HIV infection

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Immunopathogenesis of HIV Infection

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Abstract

It is thought that a significant percentage (50-70%) of human immunodeficiency virus (HIV)-infected individuals experience a clinical syndrome of variable severity during primary infection. The symptoms are non specific, typical of a flu-like syndrome [7, 10, 47], and include fever, sore throat, nausea, diarrhea, skin rash, myalgia, lymphadenopathy, and only rarely meningitis. However, due to the lack of specificity and to the variable severity of the clinical syndrome, hospitalization or medical intervention is required in only a minority of cases, and thus primary infection usually goes unnoticed.

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References

  1. Alkhatib G, Combardiere C, Broder CC, Feng Y, Kennedy PE, Murphy P, Berger E (1996) CC CKR5: a RANTES, MlP-1α, MIP-1ßreceptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272: 1955

    Article  PubMed  CAS  Google Scholar 

  2. Armstrong JA, Dawkins RL, Home R (1985) Retroviral infection of accessory cells and the immunological paradox in AIDS. Immunol Today 6: 121

    Article  Google Scholar 

  3. Asjo B, Sharma UK, Morfeldt-Manson L, Magnusson A (1990) Naturally occurring HIV-1 isolates with differences in replicative capacity are distinguished by in situ hybridization of infected cells. AIDS Res Hum Retroviruses 6: 1177

    Article  PubMed  CAS  Google Scholar 

  4. Borrow P, Lewicki H, Hahn BH, Shaw GM, Oldstone MB (1994) CTL activity associated with control of viremia in primary HIV-1 infection. J Virol 68: 6103

    PubMed  CAS  Google Scholar 

  5. Reference deleted

    Google Scholar 

  6. Choe H, Farzan M, Sun Y, Sullivan N, Rollins B, Ponath PD, Wu L, Mackay CR, LaRosa G, Newman W, Gerard N, Gerard C, Sodroski J (1996) The ß-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85: 1135

    Article  PubMed  CAS  Google Scholar 

  7. Clark SJ, Saag MS, Decker WD, Campbell-Hill S, Roberson JL, Veldkamp PJ, Kappes JC, Hahn BH, Shaw GM (1991) High titers of cytopathic virus in plasma of patients with symptomatic primary HIV-1 infection. N Engl J Med 324: 954

    Article  PubMed  CAS  Google Scholar 

  8. Cocchi F, DeVico AL, Garzino-Demo A, Ayra SK, Gallo RC, Lusso P (1996) Identification of RANTES, MlP- α, and MIP-1ßas the major HIV-suppressive factors produced by CD8+ T cells. Science 270: 1811

    Article  Google Scholar 

  9. Coffin JM (1995) HIV population dynamics in vivo: implications for genetic variation, pathogenesis, and therapy Science 267: 483

    CAS  Google Scholar 

  10. Daar ES, Moudgil T, Meyer RD, Ho DD (1991) Transient high levels of viremia in patients with primary human immunodeficiency virus type 1 infection. N Engl J Med 324: 961

    Article  PubMed  CAS  Google Scholar 

  11. Deng H, Liu R, Ellmeier W, Choe W, Nutmaz D, Burkhart M, Di Marzio P, Marmon S, Sutton RE, Hill CM, Davis CB, Peiper SC, Schall TJ, Littman DR, Laudau NR (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature 381: 661

    Article  PubMed  CAS  Google Scholar 

  12. Denis M, Ghadirian E (1994) Mycobacterium avium infection in HIV-1-infected subjects increases monokine secretion and is associated with enhanced viral load and diminished immune response to viral antigens. Clin Exp Immunol 97:76–82

    Google Scholar 

  13. Doranz BJ, Rucker J, Yi Y, Smyth RJ, Samson M, Peiper SC, Parmentier M, Collman RG, Doms RW (1996) A dual-tropic primary HIV-1 isolate that uses fusin and the b-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85: 1149

    Article  PubMed  CAS  Google Scholar 

  14. Dragic T, Litwin V, Allaway GP, Martin SR, Huang Y, Nagashima KA, Cayanan C, Maddon PJ, Koup R, Moore JP, Paxton WA (1996) HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381: 667

    Article  PubMed  CAS  Google Scholar 

  15. Embretson J, Zupancic M, Ribas JL, Burke A, Tenner-Racz K, Haase AT (1993) Massive covert infection of helper T lymphocytes and macrophages by HIV during the incubation period of AIDS. Nature 362: 359

    Article  PubMed  CAS  Google Scholar 

  16. Emilie D, Peuchmaur M, Maillot M, Crevon M, Brousse N, Delfraissy J, Dormont J, Galanaud P (1990) Production of interleukins in human immunodeficiency virus-1-replicating lymph nodes. J Clin Invest 86: 148

    Article  PubMed  CAS  Google Scholar 

  17. Fox CH, Tenner-Racz K, Racz P, Firpo A, Pizzo PA, Fauci AS (1991) Lymphoid germinal centers are reservoirs of human immunodeficiency virus type 1 RNA. J Infect Dis 164: 1051

    Article  PubMed  CAS  Google Scholar 

  18. Graziosi C, Pantaleo G, Butini L, Demarest JF, Saag MS, Shaw GM, Fauci AS (1993) Kinetics of HIV DNA and RNA synthesis during primary HIV-1 infection. Proc Natl Acad Sci USA 90: 6505

    Article  Google Scholar 

  19. Graziosi C, Gantt KR, Vaccarezza M, Demarest JF, Daucher MB, Saag MS, Shaw GM, Quinn TC, Cohen OJ, Welbon C, Pantaleo G, Fauci AS (1996) Kinetics of cytokine expression during primary human immunodeficiency virus type 1 (HIV-1) infection. Proc Natl Acad Sci USA, 93: 4386

    Article  PubMed  CAS  Google Scholar 

  20. Guidotti LG, Ishikawa T, Hobbs MV, Matzke B, Scrieber, Chisari FV (1996) Intracellular inactivation of the hepatitis B virus by cytotoxic T lymphocytes. Immunity 4: 25

    Article  PubMed  CAS  Google Scholar 

  21. . Health SL, Tew JG, Szakal AK, Burton GF (1995) Follicular dendritic cells and human immunodeficiency virus. Nature 377: 740

    Article  Google Scholar 

  22. Heng MCY, Heng SY, Allen SG (1994) Co-infection and synergy of human immunodeficiency virus-1 and herpes simplex virus-1. Lancet 343: 255

    Article  PubMed  CAS  Google Scholar 

  23. Ho DD (1992) HIV-1 viraemia and influenza. Lancet 339: 1549

    Article  PubMed  CAS  Google Scholar 

  24. Israel-Biet D, Cadranel J, Even P (1993) Human immunodeficiency virus production by alveolar lymphocytes is increased during Pneumocystis cariniipneumonia. Am Rev Respir Dis 148: 1308

    PubMed  CAS  Google Scholar 

  25. Koot M, Keet IP, Vos AH, deGoede RE, Roos MT, Coutinho RA, Miedema F, Schellekens PT, Tersmette M (1993) Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS. Ann Intern Med 118: 681

    PubMed  CAS  Google Scholar 

  26. Koup RA, Safrit JT, Cao Y, Andrews CA, McLeod G, Ho DD (1994) Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome. J Virol 68: 4650

    PubMed  CAS  Google Scholar 

  27. Mackewicz CF, Ortega HW, Levy JA (1991) CD8+ cell anti-HIV activity correlates with the clinical state of the infected individuals. J Clin Invest 87: 1462

    Article  PubMed  CAS  Google Scholar 

  28. Meier UC, Klenerman P, Griffin P, James W, Koppe B, Larder B, McMichael A, Phillips R (1995) Cytotoxic T lymphocyte lysis inhibited by viable HIV mutants. Science 270: 1360

    Article  PubMed  CAS  Google Scholar 

  29. Moore JP, Cao Y, Ho DD, Koup RA (1994) Development of the anti-gpl20 antibody response during seroconversion to human immunodeficiency virus type 1. J Virol 68: 5142

    PubMed  CAS  Google Scholar 

  30. Pantaleo G, Fauci AS (1995) New concepts in the immunopathogenesis of HIV infection. Annu Rev Immunol 13: 487

    Article  PubMed  CAS  Google Scholar 

  31. Pantaleo G, Fauci AS (1996) Immunopathogenesis of HIV infection. Annu Rev Microbiol 50: 825

    Article  PubMed  CAS  Google Scholar 

  32. Pantaleo G, Graziosi C, Butini L, Pizzo PA, Schnittman SM, Kotler DP, Fauci AS (1991) Lymphoid organs function as major reservoirs for human immunodeficiency virus. Proc Natl Acad Sci USA 88: 9838

    Article  PubMed  CAS  Google Scholar 

  33. Pantaleo G, Graziosi C, Demarest JF, Butini L, Montroni M, Fox CH, Orenstein JM, Kotler DP, Fauci AS (1993) HIV infection is active and progressive in lymphoid tissue during the clinically latent stage of disease. Nature 362: 355

    Article  PubMed  CAS  Google Scholar 

  34. Pantaleo G, Graziosi C, Fauci AS (1993) The role of lymphoid organs in the pathogenesis of HIV infection. Semin Immunol 5: 157

    Article  PubMed  CAS  Google Scholar 

  35. Pantaleo G, Graziosi C, Fauci AS (1993) The role of lymphoid organs in the immunopathogenesis of HIV infection. AIDS 7: S19

    Article  PubMed  Google Scholar 

  36. Pantaleo G, Demarest JF, Soudeyns H, Graziosi C, Denis F, Saag M, Shaw GM, Sekaly RP, Fauci AS (1994) Major expansion of CD8+ T cells with a predominant Vßusage during the primary immune response of HIV. Nature 370: 463

    Article  PubMed  CAS  Google Scholar 

  37. Pantaleo G, Graziosi C, Demarest JF, Cohen OJ, Vaccarezza M, Muro-Cacho C, Fauci AS (1994) Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol Rev 140: 105

    Article  PubMed  CAS  Google Scholar 

  38. Pantaleo G, Demarest JF, Schacker T, Vaccarezza M, Cohen OJ, Daucher MB, Graziosi C, Schnittman SM, Quinn TC, Shaw GM, Perrin L, Tambussi G, Lazzarin A, Sekaly RP, Soudeyns H, Corey L, Fauci AS (1997) The qualitative nature of the primary immune response to HIV infection is a prognosticator of disease progression independent of the initial level of plasma viremia. Proc Natl Acad Sci USA 94: 254

    Article  PubMed  CAS  Google Scholar 

  39. Philips RE, Rowland-Jones S, Nixon DF, Gotch FM, Edwards JP, Ogunlesi AO, Elvin JG, Rothbard JA, Bangham CR, Rizza CR, McMichael A (1991) Human immunodeficiency virus genetic variation that can escape cytotoxic T cell recognition. Nature 354: 453

    Article  Google Scholar 

  40. Reimann KA, Tenner-Racz K, Racz P, Montefiori DC, Yasutomi Y, Letvin NL (1994). Immunopathogenic events in acute infection of Rhesus monkeys with simian immunodeficiency virus of Macaques. J Virol 68: 2362

    PubMed  CAS  Google Scholar 

  41. Schellekens PT, Tersmette M, Roos MT, Keet RP, Wolf F de, Coutinho RA, Miedema F (1992) Biphasic rate of CD4+ cell count decline during progression to AIDS correlates with HIV-1 phenotype. AIDS 6: 665

    Article  PubMed  CAS  Google Scholar 

  42. Schuitemaker H, Koot M, Koostra NA, Dercksen MW, Goede REY de, Steenwijk RP van, Lange JM, Schattenkerk JK, Miedema F, Tersmette M (1992) Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. J Virol 66: 1354

    PubMed  CAS  Google Scholar 

  43. Spiegel H, Herbst H, Niedobitek G, Foss HD, Stein H (1992) Follicular dendritic cells are a major reservoir for human immunodeficiency virus type 1 in lymphoid tissues facilitating infection of CD4+ T-helper cells. Am J Pathol 140: 15

    PubMed  CAS  Google Scholar 

  44. Tenner-Racz K, Racz P, Dietrich M, Karin P (1985) Altered follicular dendritic cells and virus-like particles in AIDS and AIDS related lymphadenopathy. Lancet 1: 105

    Article  PubMed  CAS  Google Scholar 

  45. Tersmette M, Goede RE de, Al BJ, Winkel IN, Gruters RA, Cuypers HT, Huisman HG, Miedema F (1988) Differential syncytium-inducing capacity of human immunodeficiency virus isolates: frequent detection of syncytium-inducing isolates in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. J Virol 62: 2026

    PubMed  CAS  Google Scholar 

  46. Tersmette M, Gruters RA, Wolf F de, Goede RE de, Lange JM, Schellekens PT, Goudsmit J, Huisman HG, Miedema F (1989) Evidence for a role of virulent human immunodeficiency virus (HIV) variants in the pathogenesis of acquired immunodeficiency syndrome: sudies on sequential HIV isolates. J Virol 63: 2118

    PubMed  CAS  Google Scholar 

  47. Tindall B, Cooper DA (1991) Primary HIV infection: host responses and intervention strategies. AIDS 5:1

    Article  PubMed  CAS  Google Scholar 

  48. Zhang Y, Nakata K, Weiden M, Rom WN (1995) Mycobacterium tuberculosisenhances human immunodeficiency virus-1 replication by transcriptional activation at the long terminal repeat. J Clin Invest 95: 2324

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Laboratory of AIDS Immunopathogenesis, Department of Internal Medicine, Division of Infectious Diseases, Centre Hospitalier Universitaire Vaudois (CHUV), CH-1011, Lausanne, Switzerland

    Guiseppe Pantaleo & Cecilia Graziosi

  2. Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 31, 31 Center Drive MSC 2520, Room 7A-03, MD, 20892-2520, USA

    Anthony S. Fauci

Authors
  1. Guiseppe Pantaleo
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  2. Cecilia Graziosi
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  3. Anthony S. Fauci
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Editors and Affiliations

  1. Laboratory of Immunoregulation National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10 Center Drive MSC 1876 Building 10, Room 11B13, 20892-1876, Bethesda, MD, USA

    Anthony S. Fauci

  2. Laboratory of AIDS Immunopathogenesis Department of Medicine Division of Infectious Diseases, Centre Hospitalier Universitaire Vadois (CHUV), 1011, Lausanne, Switzerland

    Giuseppe Pantaleo

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© 1997 Springer-Verlag Berlin Heidelberg

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Pantaleo, G., Graziosi, C., Fauci, A.S. (1997). Virologic and immunologic events in primary HIV infection. In: Fauci, A.S., Pantaleo, G. (eds) Immunopathogenesis of HIV Infection. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60867-4_2

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  • DOI: https://doi.org/10.1007/978-3-642-60867-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64593-8

  • Online ISBN: 978-3-642-60867-4

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