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Tumour Targeting Using Peptides, Monoclonal Antibodies and Fragments

  • Conference paper
Impact of Molecular Biology and New Technical Developments in Diagnostic Imaging

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 22))

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Abstract

The cell surface is a complex reflection of the events in its nucleus and cytoplasm. At the same time, the activities of the nucleus and the cytoplasm depend on chemical information transmitted from the cell surface by signal transduction. This interaction results in exploitable differences between the surface properties of a cancer cell and its normal and benign counterparts. Tumour targetting using radiolabeled peptides, monoclonal antibodies and fragments makes use of all of these properties.

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References

  • Alexander C, Villena-Heinsen CE, Trampert K et al (1995) Radioimmunoscin-tigraphy of ovarian tumours with technetium-99m labelled monoclonal antibody-170: first clinical results. J Nucl Med 22:645–651

    Article  CAS  Google Scholar 

  • Babaian RJ, Sayer J, Podoloff DAS et al (1994) Radioimmunoscintigraphy of pelvic lymph nodes with 111indium-labelled monoclonal antibody CYT-356. J Urol 152:1952–1955

    PubMed  CAS  Google Scholar 

  • Bard DR, Knight CG, Wraight EP et al (1992) The use of a chelating derivative of alpha melanocyte stimulating hormone for the clinical imaging of malignant melanoma. Br J Radiol 65:112–118

    Article  PubMed  Google Scholar 

  • Barone B, Chianelli M, Bottom U et al (1996) In vivo detection of lymphocytic infiltration in melanoma using 99m-Tc-IL2. Eur J Nucl Med 23:1217

    Google Scholar 

  • Baum RP, Hertel A, Lorenz et al (1989) 99mTe-labelled anti-CEA monoclonal antibody for tumour immunoscintigraphy: first clinical results. Nucl Med Commun 10:345–348

    Article  PubMed  CAS  Google Scholar 

  • Bomanji J, Hungerford JL, Granowska M, Britton KE (1987a) Radioimmunos-cintigraphy of ocular melanoma with 99mTc labelled cutaneous melanoma antibodies. Br J Ophtalmol 71:651–658

    Article  CAS  Google Scholar 

  • Bomanji JB, Levison DA, Flatman WD et al (1987b) Uptake of I-123 metaio-dobenzylguanidine by phaeochromocytomas other paragangliomas and neuroblastomas: a histopathological comparison. J Nucl Med 28:973–978

    PubMed  CAS  Google Scholar 

  • Britton KE (1995) The tissue characterisation of malignancy with radionuclide studies. In: Bergmann H, Sinzinger M (eds) Radioactive isotopes in clinical medicine and research. 21st Bad Gastein symposium. Birkhauser, Basel, pp 249–280

    Google Scholar 

  • Britton KE, Granowska M (1987) Radioimmunoscintigraphy in tumour identification. Cancer Surv 6:247–267

    PubMed  CAS  Google Scholar 

  • Britton KE, Granowska M (1993) The present and future of radiolabeled antibodies in oncology. Ann Nucl Med 7:127–132

    Article  PubMed  CAS  Google Scholar 

  • Britton KE, Mather SJ, Granowska M (1993) Radiolabelled monoclonal antibodies in oncology. III. Radioimmunotherapy. Nucl Med Commun 12:333–347

    Google Scholar 

  • Buraggi GL, Callegaro I, Mariani G et al (1985) Imaging with 131-I-labelled monoclonal antibodies to a high-molecular weight melanoma-associated antigen in patients with melanoma: efficacy of whole immunoglobulin and its F(ab1)2 fragments. Cancer Res 45:3378–3387

    PubMed  CAS  Google Scholar 

  • Chester KA, Begent RH, Robson L et al (1994) Phage libraries for generation of clinically useful antibodies. Lancet 343:455–456

    Article  PubMed  CAS  Google Scholar 

  • Collier BD, Abdel-Nabi H, Doerr RJ et al (1993) Radioimmunoscintigraphy performed with In-111-labelled-CYT-103 in the management of colorectal cancer: comparison with CT. Radiology 185:179–186

    Google Scholar 

  • Crippa F, Buraggi GL, Di Re E et al (1991) Immunoscintigraphy of ovarian cancer with the MOV18 monoclonal antibody. Eur J Cancer 27:724–729

    Article  PubMed  CAS  Google Scholar 

  • Doerr RJ, Abdel-Nabi H, Krag D, Mitchell E (1991) Radiolabelled antibody imaging in the management of colorectal cancer. Arch Surg 214:118–124

    CAS  Google Scholar 

  • Epenetos AA, Britton KE, Mather SJ et al (1982) Targetting of iodine-123-labelled tumour associated monoclonal antibodies to ovarian, breast and gastrointestinal tumours. Lancet 2:999–1004

    Article  PubMed  CAS  Google Scholar 

  • Feneley M, Chengazi VU, Kirby RS et al (1996) Prostatic Radioimmunoscintigraphy: preliminary results using Tc-99m labelled monoclonal antibody, CYT351. Br J Urol 77:373–381

    Article  PubMed  CAS  Google Scholar 

  • Fraser CM (1994) Structure and functional analysis of G protein-coupled receptors and potential diagnostic ligands. J Nucl Med 36 [Suppl]: 175–215

    Google Scholar 

  • Granowska M, Shepherd J, Britton KE et al (1984) Ovarian cancer: diagnosis using I123 monoclonal antibody in comparison with surgical findings. Nucl Med Commun 5:485–499

    Article  PubMed  CAS  Google Scholar 

  • Granowska M, Britton KE, Shepherd JH et al (1986) A prospective study of 123-I labelled monoclonal antibody imaging in ovarian cancer. J Clin Oncol 4:730–746

    PubMed  CAS  Google Scholar 

  • Granowska M, Nimmon CC, Britton KE et al (1988) Kinetic analysis and probability mapping applied to the detection of ovarian cancer by radioim-munoscintigraphy. J Nucl Med 29:599–607

    PubMed  CAS  Google Scholar 

  • Granowska M, Jass JR, Britton KE, Northover MSA (1989) A prospective study of the use of 111In-labelled monoclonal antibody against carcino-em-bryonic antigen in colorectal cancer and of some biological factors affecting its uptake. Int J Colorect Dis 4:97–108

    Article  CAS  Google Scholar 

  • Granowska M, Mather SJ, Britton KE et al (1990a) 99mTc radioimmunoscinti-graphy of colorectal cancer. Br J Cancer 62 [Suppl X]:30–33

    Google Scholar 

  • Granowska M, Mather SJ, Jobling T et al (1990b) Radiolabelled stripped mucin SM3 monoclonal antibody for immunoscintigraphy of ovarian tumours. Int J Biol Mark 5:89–96

    CAS  Google Scholar 

  • Granowska M, Mather SJ, Britton KE (1991) Diagnostic evaluation of 111In and 99mTc radiolabelled monoclonal antibodies in ovarian and colorectal cancer: correlations with surgery. Nucl Med Biol 18:413–424

    CAS  Google Scholar 

  • Granowska M, Britton KE, Mather SJ et al (1993a) Radioimmunoscintigraphy with technetium-99m-labelled monoclonal antibody, SM3, in gynaecological cancer. Eur J Nucl Med 20:483–489

    PubMed  CAS  Google Scholar 

  • Granowska M, Britton KE, Mather SJ et al (1993b) Radioimmunosintigraphy with technetium-99m labelled monoclonal antibody, 1A3, in colorectal cancer. Eur J Nucl Med 20:690–698

    PubMed  CAS  Google Scholar 

  • Granowska M, Biassoni L, Carroll MJ et al (1996) Breast cancer Tc-99m SM3 radioimmunoscintigraphy. Acta Oncol 35:319–321

    Article  PubMed  CAS  Google Scholar 

  • Hnatowich SJ, Mardirossian G, Fogartasi M (1995) Properties of single-stranded phosphodiester and phosphothioate DNA labelled with technetium-99m. J Nucl Med 36:103

    Google Scholar 

  • Hofnagel CA, de Kraker J, Valdes Olmes RA, Voute PA (1994) 131-I-MIBG as a first line treatment in high risk neuroblastoma patients. Nucl Med Commun 15:712–717

    Article  Google Scholar 

  • Holliger P, Prosperio T, Winter G (1993) “Diabodies” small bivalent and bispe-cific antibody fragments. Proc Natl Acad Sci USA 90:6444–6448

    Article  PubMed  CAS  Google Scholar 

  • Howell R, Morris G, Granowska M et al (1995) Peroperative radioimmunode-tection (PROD) of colorectal cancer using Tc-99m PR1A3 monoclonal antibody. Tumori 81 [Suppl]: 107–108

    PubMed  CAS  Google Scholar 

  • Krenning EP, Kwekkeboom DJ, Bakker WH et al (1993) Somatostatin receptor scintigraphy with 111-In-DTPA-D-PheI-and 123-I-Tyr 3-octreotide: the Rotterdam experience with more than 1000 patients. Eur J Nucl Med 20:716–731

    Article  PubMed  CAS  Google Scholar 

  • Krenning EP, Kwekkeboom DJ, Pauwels S et al (1995) Somatostatin receptor scintigraphy. Nucl Med Ann 1–50

    Google Scholar 

  • Kuhn JA, Corbisiero RM, Buras RR et al (1991) Intraperoperative gamma detection with presurgical imaging in colon cancer. Arch Surg 126:1398–1403

    PubMed  CAS  Google Scholar 

  • Lamberts SWJ, Krenning EP, Reubi JC (1991) The role of somatostatin and its analogs in the diagnosis and treatment of tumours. Endocr Rev 12:450–482

    Article  PubMed  CAS  Google Scholar 

  • Lind P, Lechner P, Adrian-Schad K et al (1991) Anticarcinoembryonic antigen immunoscintigraphy (technetium-99m monoclonal antibody BW 431/26) and serum CEA levels in patients with suspected primary and recurrent colorectal carcinoma. J Nucl Med 32:1319–1325

    PubMed  CAS  Google Scholar 

  • Martin EW, Hinkle GH, Tuttle S et al (1985) Intraoperative radioimmunodetection of colorectal tumour with a hand held radiation detector. Am J Surg 150:672–675

    Article  PubMed  CAS  Google Scholar 

  • McEwan AJB, Maclean G, Goldberg L et al (1994) Evaluating Radioimmu-noscintigraphy in patients with breast cancer. Eur J Nucl Med 21:748

    Google Scholar 

  • Paganelli G, Malcovati M, Fazio F (1993) Monoclonal antibody pretargetting techniques for tumour localisation; the avidin biotin system. Nucl Med Commun 12:211–234

    Article  Google Scholar 

  • Paganelli G, Stella M, Zito F et al (1994) Radioimmunoguided surgery using iodine-125-labelled-18-biotinylated monoclonal antibodies and cold avidin. J Nucl Med 35:1970–1975

    PubMed  CAS  Google Scholar 

  • Shapiro B, Copp Je, Sisson JC et al (1985) I-131 metaiodobenzylguanidine for the locating of suspected phaeochromocytomas: experience in 400 cases. J Nucl Med 26:576–585

    PubMed  CAS  Google Scholar 

  • Sheritz J, Sharkey RM, Goldenberg DM (1994) Preclinical evaluation of a chimeric and humanised anti-B-cell lymphoma antibody. J Nucl Med 35:236

    Google Scholar 

  • Siccardi AG, Buraggi GL, Callegaro L et al (1986) Multicentre study of immunoscintigraphy with radiolabeled monoclonal antibodies in patients with melanoma. Cancer Res 46:4817–4822

    PubMed  CAS  Google Scholar 

  • Siccardi AG, Buraggi GL, Natali PG et al (1990) European multicentre study on melanoma immunoscintigraphy by means of 99mTc-labelled monoclonal antibody fragments. Eur J Nucl Med 16:317–323

    Article  PubMed  CAS  Google Scholar 

  • Signore A, Chianelli M, Ferretti E et al (1994) A new approach for the in vivo detection of insulinitis in type I diabetes: activated lymphocyte targetting with I-123 labelled interleukin-2. Eur J Endocrinol 131:431–437

    Article  PubMed  CAS  Google Scholar 

  • Tyson IB, Heal AV, Tenorio L et al (1991) Immunoscintigraphy and pharmacokinetics of an 111-In-Moab-C5.3 (CYT-356) for prostate cancer. J Nucl Med 32:1054

    Google Scholar 

  • Ur E, Mather SJ, Bomanji J, Ellison D, Britton KE, Grossman AB (1993a) Pituitary imaging using a labelled somatostatin analogue in acromegaly. Clin Endocrinol (Oxf) 36:147–150

    Article  Google Scholar 

  • Ur E, Bomanji J, Mather SJ, Britton KE, Wass JAH, Grossman AB, Besser GM (1993b) Localization of neuroendocrine tumours and insulinomas using radiolabelled somatostatin analogies, 123I-Tyr3-octreotide and 111Inpentetreotide. Clin Endocrinol (Oxf) 38:501–506.

    Article  CAS  Google Scholar 

  • Urbain JLC, Shore SK, Vekmans MC et al (1995) Scintigraphic imaging of oncogenes with antisense probes: does it make sense? Eur J Nucl Med 22:499–504

    Article  PubMed  CAS  Google Scholar 

  • Virgolini I, Raderer M, Kurtaran A et al (1994) Vasoactive intestinal peptide receptor imaging for the localisation of intestinal adenocarcinomas and endocrine tumours. N Engl J Med 331:1116–1121

    Article  PubMed  CAS  Google Scholar 

  • Winter G, Griffiths AD, Hawkins RE, Hoogenboom HR (1994) Making antibodies by phage display technology. Annu Rev Immunol 12:433–455

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. K. E. Britton
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Editors and Affiliations

  1. Institut für Diagnostikforschung GmbH an der Freien Universität Berlin, Spandauer Damm 130, 14050, Berlin-Charlottenburg, Germany

    W. Semmler

  2. Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany

    M. Schwaiger

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© 1997 Springer-Verlag Berlin Heidelberg

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Britton, K.E. (1997). Tumour Targeting Using Peptides, Monoclonal Antibodies and Fragments. In: Semmler, W., Schwaiger, M. (eds) Impact of Molecular Biology and New Technical Developments in Diagnostic Imaging. Ernst Schering Research Foundation Workshop, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60844-5_6

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  • DOI: https://doi.org/10.1007/978-3-642-60844-5_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64581-5

  • Online ISBN: 978-3-642-60844-5

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