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In Vivo Monitoring of Gene Therapy by Radiotracer Imaging

  • Conference paper
Impact of Molecular Biology and New Technical Developments in Diagnostic Imaging

Part of the book series: Ernst Schering Research Foundation Workshop ((SCHERING FOUND,volume 22))

Abstract

The increasing knowledge of the genetics and molecular biology of human disease, particularly in human cancer (Culver and Blaese 1994), has led to the application of new biological approaches in therapy. A limitation of many biological-based therapies has been our inability to achieve controlled and effective delivery of biologically active molecules to tumor cells or their surrounding matrix. This condition is particularly limiting for biologically active compounds that have very short half-lives and exhibit site-specific therapeutic and toxic effects. Gene-based therapy can provide control over the level, timing, and duration of action of these biologically active products by including specific promoter/activator elements in the genetic material transferred, resulting in more effective therapeutic interventions. Methods are actively being developed for controlled gene delivery to various somatic tissues and tumors using novel formulations of DNA and for controlling gene expression using cell-specific, replication-activated, and drug-controlled expression systems (Jolly 1994).

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Authors
  1. R. G. Blasberg
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  2. J. G. Tjuvajev
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Editor information

Editors and Affiliations

  1. Institut für Diagnostikforschung GmbH an der Freien Universität Berlin, Spandauer Damm 130, 14050, Berlin-Charlottenburg, Germany

    W. Semmler

  2. Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, München, Germany

    M. Schwaiger

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© 1997 Springer-Verlag Berlin Heidelberg

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Blasberg, R.G., Tjuvajev, J.G. (1997). In Vivo Monitoring of Gene Therapy by Radiotracer Imaging. In: Semmler, W., Schwaiger, M. (eds) Impact of Molecular Biology and New Technical Developments in Diagnostic Imaging. Ernst Schering Research Foundation Workshop, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60844-5_11

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  • DOI: https://doi.org/10.1007/978-3-642-60844-5_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64581-5

  • Online ISBN: 978-3-642-60844-5

  • eBook Packages: Springer Book Archive

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