Abstract
Precise targeting of pathogenic tissues is of extraordinary importance in medical diagnosis and therapy. The generation of monoclonal antibodies and the technical development in the use of these specific molecules has created high expectations in these fields. The large size as well as the antigenic potential are major limitations of the antibody technology.
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References
Abola EE, Bernstein FC, Bryant SH, Koetzle TF, Weng J (1987) Protein data bank. In: Allen FH, Bergerhoff G, Sievers R (eds) Crystallographic databases — information content, software systems, scientific applications. Data Commission of the International Union of Crystallography, Bonn/Cambridge/Chester, pp 107–132
Allen P, Worland S, Gold L (1995) Isolation of high-affinity RNA ligands to HIV-1 integrase from a random pool. Virology 209:327–336
Aurup H, Tuschl T, Benseler F, Ludwig J, Eckstein F (1994) Oligonucleotide duplexes containing 2′-amino-2′-deoxycytidines: thermal stability and chemical reactivity. Nucleic Acids Res 22:20–24
Bartel DP, Szostak JW (1993) Isolation of new ribozymes from a large pool of random sequences. Science 261:1411–1418
Bernstein FC, Koetzle TF, Williams GJB, Meyer JEF, Brice MD, Rodgers MD, Kennard O, Shimanouchi T, Tasumi M (1977) The protein data bank: a computer-based archival file for macromolecular structures. J Mol Biol 112:535–542
Binkley J, Allen P, Brown DM, Green L, Tuerk C, Gold L (1995) RNA ligands to human nerve growth factor. Nucleic Acids Res 23:3198–3205
Bock LC, Griffin LC, Latham JA, Vermaas EH, Toole JJ (1992) Selection of single-stranded DNA molecules that bind and inhibit human thrombin. Nature 355:564–566
Bodey B, Siegel SE, Kaiser HE (1996) Human cancer detection and immunotherapy with conjugated and non-conjugated monoclonal antibodies. Anticancer Res 16:661–674
Burgstaller P, Kochoyan M, Famulok M (1995) Structural probing and damage selection of citrulline-and arginine-specific RNA aptamers identify base positions required for binding. Nucleic Acids Res 23:4769–4776
Chen H, Gold L (1994) Selection of high-affinity RNA ligands to reverse transcriptase: inhibition of cDNA synthesis and RNase H activity. Biochemistry 33:8746–8756
Chen H, McBroom DG, Zhu YQ, Gold L, North TW (1996) Inhibitory RNA ligand to reverse transcriptase from feline immunodeficiency virus. Biochemistry 35:6923–6930
Conrad R, Keranen LM, Ellington AD, Newton AC (1994) Isozyme-specific inhibition of protein kinase C by RNA aptamers. J Biol Chem 269:32051–32054
Davis KA, Abrams B, Lin Y, Jayasena SD (1996) Use of a high affinity DNA ligand in flow cytometry. Nucleic Acids Res 24:702–706
Dobbelstein M, Shenk T (1995) In vitro selection of RNA ligands for the ribo-somal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries. J Virol 69:8027–8034
Doyle PM (1995) Combinatorial chemistry in the discovery and development of drugs. J Chem Technol Biotechnol 64:317–324
Ellington AD, Szostak JW (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346:818–822
Ellington AD, Szostak JW (1992) Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures. Nature 355:850–852
Famulok M (1994) Molecular recognition of amino acids by RNA-Aptamers: an L-citrulline binding RNA motif and its evolution into an arginine binder. J Am Chem Soc 116:1698–1706
Geiger A, Burgstaller P, von der Eltz, H, Roeder A, Famulok M (1996) RNA aptamers that bind L-arginine with sub-micromolar dissociation constants and high enantioselectivity. Nucleic Acids Res 24:1029–1036
Giver L, Bartel D, Zapp M, Pawul A, Green M, Ellington AD (1993) Selective optimization of the Rev-binding element of HIV-1. Nucleic Acids Res 21:5509–5516
Gold L, Polisky B, Uhlenbeck O, Yanis M (1995) Diversity of oligonucleotide functions. Annu Rev Biochem 64:763–797
Green LS, Jellinek D, Bell C, Beebe LA, Feistner BD, Gill SC, Jucker FM, Janjic N (1995) Nuclease-resistant nucleic acid ligands to vascular permeability factor/vascular endothelial growth factor. Chem Biol 2:683–695
Harris WJ (1995) Production of humanized monoclonal antibodies for in vivo imaging and therapy. Biochem Soc Trans 23:1035–1038
Heidenreich O, Pieken W, Eckstein F (1993) Chemically modified RNA: approaches and applications. FASEB J 7:90–96
Huizenga DE, Szostak JW (1995) A DNA aptamer that binds adenosine and ATP. Biochemistry 34:656–665
Jellinek D, Green LS, Bell C, Janjic N (1994) Inhibition of receptor binding by high-affinity RNA ligands to vascular endothelial growth factor. Biochemistry 33:10450–10456
Jellinek D, Green LS, Bell C, Lynott CK, Gill N, Vargeese C, Kirschenheuter G, McGee DP, Abesinghe P, Pieken WA et al (1995) Potent 2′-amino-2′-de-oxypyrimidine RNA inhibitors of basic fibroblast growth factor. Biochemistry 34:11363–11372
Jenison RD, Gill SC, Pardi A, Polisky B (1994) High-resolution molecular discrimination by RNA. Science 263:1425–1429
Jensen KB, Atkinson BL, Willis MC, Koch TH, Gold L (1995) Using in vitro selection to direct the covalent attachment of human immunodeficiency virus type 1 Rev protein to high-affinity RNA ligands. Proc Natl Acad Sci USA 92:12220–12224
Klussmann S, Nolte A, Bald R, Erdmann VA, Fürste JP (1996) Mirror-image RNA that binds D-adenosine. Nat Biotechnol 14:1112–1115
Köhler G, Milstein C (1975) Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256:495–497
Kubik MF, Stephens AW, Schneider D, Marlar RA, Tasset D (1994) High-affinity RNA ligands to human alpha-thrombin. Nucleic Acids Res 22:2619–2626
Li Y, Geyer CR, Sen D (1996) Recognition of anionic porphyrins by DNA aptamers. Biochemistry 35:6911–6922
Lin Y, Qiu Q, Gill SC, Jayasena SD (1994) Modified RNA sequence pools for in vitro selection. Nucleic Acids Res 22:5229–5234
Lorsch JR, Szostak JW (1994) In vitro selection of RNA aptamers specific for cyanocobalamin. Biochemistry 33:973–982
Mountain A, Adair JR (1992) Engineering antibodies for therapy. Biotechnol Genet Eng Rev 10:1–142
Nieuwlandt D, Wecker M, Gold L (1995) In vitro selection of RNA ligands to substance P. Biochemistry 34:5651–5659
Nolte A, Klussmann S, Bald R, Erdmann VA, Fürste JP (1996) Mirror-design of L-oligonucleotide ligands binding to L-arginine. Nature Biotechnology 14:1116–1119
O’Connell D, Koenig A, Jennings S, Hicke B, Han HL, Fitzwater T, Chang YF, Varki N, Parma D, Varki A (1996) Calcium-dependent oligonucleotide antagonists specific for L-selectin. Proc Natl Acad Sci USA 93:5883–5887
Pasqualini R, Ruoslahti E (1996) Organ targeting in vivo using phage display peptide libraries. Nature 380:364–366
Rini JM, Stanfield RL, Stura EA, Salinas PA, Profy AT, Wilson IA (1993) Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen. Proc Natl Acad Sci USA 90:6325–6329
Robertson DL, Joyce GF (1990) Selection in vitro of an RNA enzyme that specifically cleaves single-stranded DNA. Nature 344:467–468
Sandhu JS (1992) Protein engineering of antibodies. Crit Rev Biotechnol 12:437–462
Sassanfar M, Szostak JW (1993) An RNA motif that binds ATP. Nature 364:550–553
Sayle R, Milner-White EJ (1995) RasMol: biomolecular graphics for all. TIBS 20 (9):333–379
Schneider DJ, Feigon J, Hostomsky Z, Gold L (1995) High-affinity ssDNA inhibitors of the reverse transcriptase of type 1 human immunodeficiency virus. Biochemistry 34:9599–9610
Smith D, Kirschenheuter GP, Charlton J, Guidot DM, Repine JE (1995) In vitro selection of RNA-based irreversible inhibitors of human neutrophil elas-tase. Chem Biol 2:741–750
Söll D, Rajbhandary UL (eds) (1995) tRNA: structure, biosynthesis and function. American Society for Microbiology, Washington DC
Sussman JL, Trifonov EN (1978) Possibility of nonkinked packing of DNA in chromatin. Proc Natl Acad Sci USA 75:103–107
Tian Y, Adya N, Wagner S, Giam CZ, Green MR, Ellington AD (1995) Dissecting protein:protein interactions between transcription factors with an RNA aptamer. RNA 1:317–326
Tsai DE, Keene JD (1993) In vitro selection of RNA epitopes using autoimmune patient serum. J Immunol 150:1137–1145
Tuerk C, Gold L (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249:505–510
Tuschl T, Gohlke C, Jovin TM, Westhof E, Eckstein F (1994) A three-dimensional model for the hammerhead ribozyme based on fluorescence measurements. Science 266:785–789
Tuschl T, Thomson JB, Eckstein F (1995) RNA cleavage by small catalytic RNAs. Curr Opin Struct Biol 5:296–302
Uphoff KW, Bell SD, Ellington AD (1996) In vitro selection of aptamers: the dearth of pure reason. Curr Opin Struct Biol 6:281–288
Verhoeyen ME, Saunders JA, Broderick EL, Eida SJ, Badley RA (1991) Reshaping human monoclonal antibodies for imaging and therapy. Dis Markers 9:197–203
Wallis MG, Ahsen U, Schroeder R, Famulok M (1995) A novel RNA motif for neomycin recognition. Chem Biol 2:543–552
Wang Y, Rando RR (1995) Specific binding of aminoglycoside antibiotics to RNA. Chem Biol 2:281–290
Wiegand TW, Williams PB, Dreskin SC, Jouvin MH, Kinet JP, Tasset D (1996) High-affinity oligonucleotide ligands to human IgE inhibit binding to Fc epsilon receptor I. J Immunol 157:221–230
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Wölfl, S., Kujau, M., Siebert, A., Wolters, M. (1997). Oligonucleotide Aptamers as Specific Targeting Devices in Diagnostics and Therapy. In: Semmler, W., Schwaiger, M. (eds) Impact of Molecular Biology and New Technical Developments in Diagnostic Imaging. Ernst Schering Research Foundation Workshop, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60844-5_10
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DOI: https://doi.org/10.1007/978-3-642-60844-5_10
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