Skip to main content
SpringerLink
Log in

Die Wirkung von Lithium auf das Immunsystern

  • Chapter
Die Lithiumtherapie

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Barr RD, Koekebakker M, Brown EA, Falbo MC (1987) Putative role for lithium in human hematopoiesis. J Lab Clin Med 109: 159–163

    PubMed  CAS  Google Scholar 

  • Beyaert R, Schulze-Osthoff K, Van Roy F, Fiers W (1991) Lithium chloride potentiates tumor necrosis factor-induced and interleukin 1-induced cytokine and cytokine receptor expression. 3: 282–291

    Google Scholar 

  • Bray J, Turner AR, Dusel F (1982) Lithium and the mitogenic response of human lym-phocytes. Clin Immunol Immunopathol 19: 284–288

    Article  Google Scholar 

  • Brown RL, Griffith RL, Ruscetti FW (1985) Modulation of interleukin-2 release from a primate lymphoid cell line in serum-free and serum-containing media. Cell Immunol 92: 14–21

    Article  PubMed  CAS  Google Scholar 

  • Chan HSL, Saunders EF, Freedman MH (1980) Modulation of human hematopoiesis by prostaglandins and lithium. J Lab Clin Med 95: 125–132

    PubMed  CAS  Google Scholar 

  • Crockard AD, Desai ZR, Ennis KT (1984) Circulating T-cell subpopulations in lithiumassociated granulocytosis. J Immunopharmacol 613: 215–216

    Google Scholar 

  • Ebstein RP, Lerer B, Bennett ER, Dayek DB, Newman ME, Shapira B, Kindler S (1986a) Second messenger function in lymphocytes and platelets: a comparison of peripheral and central mechanisms. Clin Neuropharmacol 4: 350–352

    Google Scholar 

  • Ebstein RP, Oppenheim G, Ebstein BS, Amiri Z, Stessman J (1986b) The cyclic AMP second messenger system in man: the effects of heredity, hormones, drugs, aluminum, age and disease on signal amplification. Prog Neuropsychopharmacol Bio Psychiatry 10: 323–353

    Article  CAS  Google Scholar 

  • Ebstein RP, Lerer B, Bennett ER, Shapira B, Kindler S, Shemesh Z, Gerstenhaber N (1988) Lithium modulation of second messenger signal amplification in man: inhibition of phosphatidylinositol-specific phospholipase C and adenylate cyclase activity. Psychiatry Res 24: 45–52

    Article  PubMed  CAS  Google Scholar 

  • Dosch HM, Matheson D, Schurman RK, Gelfand EW (1980) Antisuppressor cell effects of lithium in vitro and in vivo. Adv Exp Med Biol 127: 447–462

    PubMed  CAS  Google Scholar 

  • Doukas MA, Niskanen E, Quesenberry PJ (1986) Effect of lithium on stem cell and stromal cell proliferation in vitro. Exp Hematol 14: 214–221

    Google Scholar 

  • Fernandez LA, Fox RA (1980) Perturbation of the human immune system by lithium. Clin Exp Immunol 41: 527–532

    PubMed  CAS  Google Scholar 

  • Fernandez LA, MacSween JM (1980) Lithium and T cell colonies. Scand J Haematol 25: 382–384

    Article  PubMed  CAS  Google Scholar 

  • Fugetta MP, Alvino E, Romani L, Grohman U, Potenza C, Givliani A (1988) Increase in natural killer activity of mouse lymphocytes following in vitro and in vivo treatment with lithium. Immunopharmacol Immunotoxicol 10: 79–81

    Article  Google Scholar 

  • Gallicchio VS (1986) Lithium stimulation of in vitro granulopoiesis. Evidence for mediation via sodium transport pathways. Brit J Haematol 62: 455–466

    Article  CAS  Google Scholar 

  • Gallicchio VS (1987) Lithium and hematopoietic toxicity. II. Acceleration in vivo of murine hematopoietic progenitor cells (CFU-GM and CFU-Meg) following treatment with vinblastine sulfate. Int J Cell Cloning 5: 122–133

    Article  PubMed  CAS  Google Scholar 

  • Gallicchio VS, Murphy MJ, Jr (1983) Cation influences on in vitro growth of erythroid stem cells (CFU-E and BFU-E). Cell Tissue Res 233: 175–181

    Article  PubMed  CAS  Google Scholar 

  • Gallicchio VS, Chen MG, Watts TD, Gamba-Vitalo C (1983) Lithium stimulates the recovery of granulopoiesis following acute radiation. Exp Hematol 11: 553–563

    PubMed  CAS  Google Scholar 

  • Gallicchio VS, Chen MG, Watts TD (1984) The ability of lithium to accelerate the recovery of granulopoiesis after subacute radiation injury: role of the hematopoietic microenvironment. Acta Rad Oncol 23: 383–366

    Google Scholar 

  • Gallicchio VS, Chen MG, Watts TD (1985) Lithium stimulated recovery of granulopoiesis after sub-lethal irradiation is not mediated via increased levels of colony stimulating factor, Ont J Radiat Biol 47: 581–590

    Article  CAS  Google Scholar 

  • Gallicchio VS, Hulette BC (1988) In vitro effect of lithium on carbamazepine-induced inhibition of murine and human bone marrow-derived granulocyte-macrophage, erythroid, and megakaryocyte progenitor stem cells. Proc Soc Exp Biol Med 190: 109–116

    Google Scholar 

  • Gallicchio VS, Hughes NK, Hulette BC, Noblitt L (1991) Effect of interleukin-1, GM-CSF, erythropoietin, and lithium on the toxicity associated with 3’-azido-3’deoxythymidine (AZT) in vitro on hematopoietic progenitors (CFU-GM, CFT-MEG, and BFU-E) using murine retrovirus-infected hematopoietic cells. J Leuko Biol 50: 580–586

    PubMed  CAS  Google Scholar 

  • Gallicchio VS, Messino MJ, Hulette BC, Hughes NK (1992) Lithium and hematopoiesis: Effective experimental use of lithium as an agent to improve bone marrow transplantation. J Medicine 23: 195–216

    CAS  Google Scholar 

  • Hughes NK, Tse KF (1993) Modulation of the hematopoietic toxicity associated with zidovudine in vivo with lithium carbonate. J Int Medicine 233: 259–268

    Google Scholar 

  • Gallicchio VS, Cibull ML, Hughes NK, Tse KF, Scott KW, Birch NJ, Ling J (1994) Lithium expands the spatial distribution and increases the number of femoral bone marrow hematopoietic progenitor cells in immunodeficient mice receiving anti-viral therapy. Lithium 4: 223–233

    Google Scholar 

  • Gallicchio VS, Cibull ML, Hughes NK, Tse KF, Birch NJ (1995) Effect of lithium in immunodeficiency: improved blood cell formation in mice with decreased hematopoiesis as the result of LP-BM5 MuLV infection. AntiViral Research 26: 189–202

    Article  PubMed  CAS  Google Scholar 

  • Gallicchio VS, Hughes NK, Tse KF, Oakley O, Mayhew C, Piper J, Birch NJ (1996) Lithium and anti-viral drug toxicity III: further studies on the ability of lithium to exert anti-viral, anti-tumor effects and modulate the toxicity associated with antiviral drug therapy in normal and immunodeficient retrovirus-infected mice. In: Gallicchio VS, Birch NJ (eds) Lithium: biochemical and clinical advances. Weidner Publishing Group, Cheshire, Connecticut, pp. 85–102

    Google Scholar 

  • Gelfand EW, Dosch HM, Hastings B, Shore A (1979) Lithium: a modulator of cyclic AMP-dependent events in lymphocytes. Science 203: 365–377

    Article  PubMed  CAS  Google Scholar 

  • Gelfand EW, Cheung R, Hastings D, Dosch HM (1980) Characterization of lithium effects on two aspects of T-cell,function. Adv Exp Med Biol 127: 429–446

    PubMed  CAS  Google Scholar 

  • Hart DA (1988) Immunopharmacologic aspects of lithium: One aspect of a general role as a modulator of homeostasis. In: Birch NJ (ed) Lithium: inorganic pharmacology and psychiatric use. IRL Press, Oxford, pp. 99–102

    Google Scholar 

  • Hart DA (1990) Modulation of immune system elements by lithium. In: Bach RO, Gallicchio VS (eds) Lithium and cell physiology. Springer, New York, pp. 58–81

    Google Scholar 

  • Hart DA (1992) Differential potentiation of in vitro lipopolysaccharide stimulation of B-lymphoid cells by different mechanisms. Cell Immunol 71: 169–182

    Article  Google Scholar 

  • Hruba A, Paluska E, Chudomel V (1986) Influence of the incubation of cells with zinc and lithium ions on GVH reactivity of cells on their ability to form haematopoietic colonies. Folia Biol 32: 81–90

    CAS  Google Scholar 

  • Humes JL (1988) Regulation of leukotriene formation in inflammatory cells. Ann NY Acad Sci 524: 252–259

    Article  PubMed  CAS  Google Scholar 

  • Ishizaka S, Moller G (1982) Lithium chloride induces partial responsiveness to LPS in nonresponder B cells. Nature 299: 363–365

    Article  PubMed  CAS  Google Scholar 

  • Krishter S, Hoffman FA, Pizzo PA (1985) Production of and response to interleukin-2 by cultured T cells: effects of lithium chloride and other putative modulators. J Biol Response Mod 4: 185–194

    Google Scholar 

  • Kucharz E, Sierakowski S, Staite N, Goodwin J (1988) Mechanism of lithium-induced augmentation of T-cell proliferation. Int J Immunopharmacol 10: 252–259

    Article  Google Scholar 

  • Klysner R, Geisler A, Rosenberg R (1987) Enhanced histamine and beta-adrenoreceptor mediated cyclic AMP formation in leukocytes from patients with endogenous depression. J Affective Disorders 13: 227–232

    Article  CAS  Google Scholar 

  • Lieb J (1987) Lithium and immune functions. Med Hypotheses 23: 73–93

    Article  PubMed  CAS  Google Scholar 

  • Lin Y, Robb RJ (1985) Induction of interleukin-2 production in the gibbon ape T cell line. Lymphokine Res 4: 1–4

    PubMed  CAS  Google Scholar 

  • Messino MJ, Gallicchio VS, Hulette BC, Gass C, Doukas MA (1988) Lithium enhances hematopoietic reconstitution in a syngeneic transplant model. Exp Hematol 16:293 Mustelin T, Poso H, Livanainen A, Andersson LC (1986) Myoinositol reverses Li+-induced inhibition of phosphoinositide turnover and ornithine decarboxylase induction during early lymphocyte action. Eur J Immunol 16: 859–861

    Google Scholar 

  • Mustelin T, Poso H, Stahls A, Eloranta T, Andersson LC (1987) Transduction of mitogenic signals in T lymphocytes. Role of inositol phospholipids for the rapid activation of ornithine decarboxylase. Scand J Immunol 26: 287–294

    Article  PubMed  CAS  Google Scholar 

  • Oh VM, Taylor EA (1987) Effects of serum, ethacrynic acid, and low external concentration of potassium on specific [3 H] -ouabain to human lymphocytes. Brit J Clin Pharmacol 24: 681–682

    CAS  Google Scholar 

  • Quesenberry PJ, Song Z, Alberico T, Gualtieri R, Stewart M (1985) Bone marrow adherent cell hematopoietic growth factor production. Prog Clin Biol Res 184: 247–256

    PubMed  CAS  Google Scholar 

  • Rapeport WG, Aronson JK, Grahame-Smith DG, Harper C (1986) The effects of serum, lithium, ethacrynic acid, and a low external concentration of potassium on specific [3H]-ouabain binding to human lymphocytes after incubation for 3 days. Brit J Clin Pharmacol 222: 275–279

    Google Scholar 

  • Reisburg B, Gershon S (1979) Side effects associated with lithium therapy. Arch Gen Psychiatry 36: 879–887

    Google Scholar 

  • Ridgeway D, Wolff LJ, Neerhout RC (1986) Enhanced lymphocyte response to PHA among leukemia patients taking oral lithium therapy. Cancer Invest 4: 513–517

    Article  Google Scholar 

  • Roberts DE, Berman, Nakasato S, Wyle FA, Wishnow RM, Segal GP (1988) Effect of lithium carbonate on zidovudine-associated neutropenia in the acquired immunodeficiency syndrome. Amer J Med 85: 428–431

    Article  PubMed  CAS  Google Scholar 

  • Schenkman L, Borkowsky W, Holzman RS, Shopsin B (1978) Enhancement of lymphocyte and macrophage function in vitro by lithium chloride. Clin Immunol Immunopathol 10: 187–192

    Article  Google Scholar 

  • Schenkman L, Borkowsky W, Shopsin B (1980) Lithium as an immunologic adjuvant. Med Hypotheses 6: 1–6

    Article  Google Scholar 

  • Scott IG, Poso H, Akerman KEO, Andersson LC (1985) Rapid activation of ornithine decarboxylase by mitogenic (but not by non-mitogenic) ligands in human T lymphocytes. Eur J Immuno 15: 783–788

    Article  CAS  Google Scholar 

  • Sengar DP, Waters BG, Dunne JV, Bouer IM (1982) Lymphocyte subpopulations and mitogenic responses of lymphocytes in manic-depressive disorders. Psychiatry 17: 1017–1022

    CAS  Google Scholar 

  • Sharma SD (1982) Lithium modulates mitogen induced killer activity and interferon production. J Immunopharmacol 83: 303–313

    Google Scholar 

  • Skinner GRB, Hartley C, Buchan A, Harper L, Gallimore P (1980) The effect of lithium chloride on the replication of Herpes simplex virus. Med Microbiol Immunol 168: 258–265

    Article  Google Scholar 

  • Sztein MB, Simon GL, Parenti DM, Scheib R, Goldstein AL, Goodman R, DiGiolia R, Paxton H, Skotnicki AB, Schulof RS (1987) In vitro effects of thymosin and lithium on lymphoproliferative responses of normal donors and HIV seropositive male homosexuals with AIDS-related complex. Clin Immunol Immunopathol 44: 51–62

    Article  PubMed  CAS  Google Scholar 

  • Townsley L, Kazim S, Hughes NK, Tse KF, Scott K, Birch NJ, Gallicchio VS (1995) Lithium and anti-viral drug toxicity: I. Further studies on the ability of lithium to modulate the hematopoietic toxicity associated with the anti-viral drug zidovudine (AZT). J Trace Microp Tech 13: 1–9

    CAS  Google Scholar 

  • Verma DS, Johnston DA, Spitzer G, Zander AR, Dicke KA, McCredie KB (1982a) The mechanism of lithium carbonate induced augmentation of colony stimulating activity elaboration in man. Leuk Res 6: 349–363

    Article  CAS  Google Scholar 

  • Verma DA, Spitzer G, Gutterman JV, Beran M, Zander Ar (1982b) Human leukocyte interferon mediated granulopoietic differentiation arrest and its abrogation by lithium carbonate. Amer J Hematol 12: 39–46

    Article  CAS  Google Scholar 

  • Verma DA, Johnston DA, McCredie KB (1983) Evidence for the separate human T-lymphocyte subpopulations that collaborate with autologous mono cyte/macrophages in the elaboration of colony-stimulating activity and those that suppress this collaboration. Blood 62: 1088–1099

    PubMed  CAS  Google Scholar 

  • Wadler S, Schenkman L, Borkowsky W (1979) Effects of lithium on suppressor enriched and suppressor depleted mononuclear cell population. Clin Res 7: 339–342

    Google Scholar 

  • Wahlin A, von Knorring L, Roos G (1984) Altered distribution of T lymphocyte subsets in lithium-treated patients. Neuropsychobiology 11: 243–246

    Article  PubMed  CAS  Google Scholar 

  • Weetman AP, McGregor AM, Lazarus JH, Smith BR, Hall R (1982) The enhancement of immunoglobulin synthesis by human lymphocytes with lithium. Clin Immunol Immunopathol 22: 400–407

    Article  PubMed  CAS  Google Scholar 

  • Wu Y, Yang XH (1991) Enhancement of interleukin-2 production in human and gibbon T cells after in vitro treatment with lithium. Proc Soc Exp Biol Med 98:620-624 Aus dem Englischen iibersetzt von Dr. med. Martin Esser von Enckevort.

    Google Scholar 

Download references

Authors
  1. V. S. Gallicchio
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Psychiatrische Klinik und Poliklinik, Freie Universität Berlin, Eschenallee 3, D-14050, Berlin, Germany

    Bruno Müller-Oerlinghausen  & Anne Berghöfer (Ärztin) &  (Ärztin)

  2. Psychiatrische Klinik, Ludwig-Maximilian-Universität München, Nußbaumstraße 7, D-80336, München, Germany

    Waldemar Greil

  3. Psychiatrische Klinik, Sanatorium Kilchberg, Alte Landstraße 70–84, CH-8802, Kilchberg Zürich, Switzerland

    Waldemar Greil

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gallicchio, V.S. (1997). Die Wirkung von Lithium auf das Immunsystern. In: Müller-Oerlinghausen, B., Berghöfer, A., Greil, W. (eds) Die Lithiumtherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60819-3_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-60819-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64570-9

  • Online ISBN: 978-3-642-60819-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation