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c-Myc Promotes Survival of WEHI 231 B Lymphoma Cells from Apoptosis

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C-Myc in B-Cell Neoplasia

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 224))

Abstract

The c-myc oncogene has been implicated in control of cell proliferation, differentiation, as well as neoplastic transformation. More recently, overexpression or inappropriate time of expression of the c-myc gene has been found to promote apoptosis. Cleveland and coworkers observed that addition of a vector expressing c-Myc protein accelerated apoptosis following IL-3 deprivation of the 32D Independent myeloid cell line [3]. Similarly Evan and coworkers [10] found that transfection of 3T3 fibroblast cells with c-myc expression vectors led to enhanced levels of apoptosis upon growth arrest either by serum or isoleucine deprivation, or a thymidine block. These findings have been further extended using c-myc antisense oligonucleotides. Green and coworkers have shown that addition of these oligonucleotides to immature T cells and some T cell hybridomas, inhibited c-myc expression and prevented T cell receptor mediated apoptosis [23]. Together these results strongly suggest that inappropriate overexpression of c-myc promotes apoptosis in some cell systems.

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Author information

Authors and Affiliations

  1. Department of Biochemistry, University School of Medicine, Boston, MA, 02118, USA

    M. Wu, W. Yang, R. E. Bellas, M. J. FitzGerald, H. Lee & G. E. Sonenshein

  2. Department of Microbiology, University School of Medicine, Boston, MA, 02118, USA

    S. L. Schauer

Authors
  1. M. Wu
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  2. W. Yang
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  3. R. E. Bellas
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  4. S. L. Schauer
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  5. M. J. FitzGerald
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  6. H. Lee
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  7. G. E. Sonenshein
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, Building 37, Room 2B04, National Cancer Institute, National Institutes of Health, 37 Convert Drive MSC4255, Bethesda, MD, 20892-4255, USA

    Michael Potter M.D. (Chief) (Chief)

  2. Basel Institute for Immunology, Grenzacherstr. 487, CH-4055, Basel, Switzerland

    Fritz Melchers (Director) (Director)

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© 1997 Springer-Verlag Berlin Heidelberg

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Wu, M. et al. (1997). c-Myc Promotes Survival of WEHI 231 B Lymphoma Cells from Apoptosis. In: Potter, M., Melchers, F. (eds) C-Myc in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 224. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-60801-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-60801-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64560-0

  • Online ISBN: 978-3-642-60801-8

  • eBook Packages: Springer Book Archive

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