Receptor-specific Regulation of NF-κB, c-Myc and Fas-mediated Apoptosis in Primary B Cells

  • D. A. Francis
  • R. Sen
  • T. L. Rothstein
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 224)


The NF-κB transcription factor complex plays a role in directing the inducible expression of a number of genes involved in the immune response, importantly including c-myc [1]. NF-κB consists of homo- or hetero-dimers drawn from a family of proteins, the members of which share a conserved 300 amino acid sequence, the Rel homology domain, originally identified as the transforming agent of the avian reticuloendotheliosis virus. Mammahan Rel-related proteins include NF-κB 1 (p50), NF-κB2 (p52), c-Rel, RelA (p65), and RelB. NF-κB 1 and NF-κB2 are derived from larger precursor proteins (pl05 and p 100, respectively) that can inhibit NF-κB. c-Rel, RelA and RelB contain transactivation domains at their carboxyl terminal ends that are capable of activating gene transcription. Transcriptionally active dimers are those in which one of the proteins contains a transactivation domain (for review see [2–4]).


Electrophoretic Mobility Shift Assay Cell Stimulation Nuclear Expression Transcription Factor Complex Nucleoprotein Complex 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • D. A. Francis
    • 1
  • R. Sen
    • 2
  • T. L. Rothstein
    • 3
  1. 1.Department of PathologyBoston University Medical CenterBostonUSA
  2. 2.Department of BiologyBrandeis UniversityWalthamUSA
  3. 3.Department of Medicine and MicrobiologyBoston University Medical CenterBostonUSA

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