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Receptor-specific Regulation of NF-κB, c-Myc and Fas-mediated Apoptosis in Primary B Cells

  • D. A. Francis
  • R. Sen
  • T. L. Rothstein
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 224)

Abstract

The NF-κB transcription factor complex plays a role in directing the inducible expression of a number of genes involved in the immune response, importantly including c-myc [1]. NF-κB consists of homo- or hetero-dimers drawn from a family of proteins, the members of which share a conserved 300 amino acid sequence, the Rel homology domain, originally identified as the transforming agent of the avian reticuloendotheliosis virus. Mammahan Rel-related proteins include NF-κB 1 (p50), NF-κB2 (p52), c-Rel, RelA (p65), and RelB. NF-κB 1 and NF-κB2 are derived from larger precursor proteins (pl05 and p 100, respectively) that can inhibit NF-κB. c-Rel, RelA and RelB contain transactivation domains at their carboxyl terminal ends that are capable of activating gene transcription. Transcriptionally active dimers are those in which one of the proteins contains a transactivation domain (for review see [2–4]).

Keywords

Electrophoretic Mobility Shift Assay Cell Stimulation Nuclear Expression Transcription Factor Complex Nucleoprotein Complex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • D. A. Francis
    • 1
  • R. Sen
    • 2
  • T. L. Rothstein
    • 3
  1. 1.Department of PathologyBoston University Medical CenterBostonUSA
  2. 2.Department of BiologyBrandeis UniversityWalthamUSA
  3. 3.Department of Medicine and MicrobiologyBoston University Medical CenterBostonUSA

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