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Differential Regulation of the c-MYC P1 and P2 Promoters in the Absence of Functional Tumor Suppressors: Implications for Mechanisms of Deregulated MYC Transcription

  • K. B. Marcu
  • A. J. Patel
  • Y. Yang
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 224)

Abstract

The c-MYC polypeptide plays critical roles in cellular proliferation and differentiation and its dysregulation can lead to abnormal growth, neoplasia and death [1,2]. MYC normally initiates a cell cycle progression program culminating in S phase whilst enforced MYC expression can inhibit cellular differentiation programs and excessive levels of MYC lead to the induction of apoptosis (programmed cell death) [1–3]. The MYC polypeptide functions as a transcriptional activator (a member of the basic-helix-loop-helix family of heterodimerizing proteins) and as such is very likely the master regulator of many genes in diverse cellular contexts [1,2,4]. The pivotal contributions of the MYC polypeptide to cellular gene control and physiology are accomplished by its own tight regulation [1,2,5]. The c-MYC polypeptide and its mRNA are extremely short lived in vivo and are generally expressed at low levels in normal proliferating cells [2,5]. Minor fluctuations in MYC protein and/or mRNA levels can have dramatic outcomes on cellular physiology. Consequently, mammalian MYC gene expression is subject to tight control at multiple levels.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • K. B. Marcu
    • 1
  • A. J. Patel
    • 1
  • Y. Yang
    • 1
  1. 1.Department of Biochemistry and Cell Biology, Institute for Cell and Developmental BiologyState University of New York at Stony BrookStony BrookUSA

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