Dysregulation of c-myc in Multiple Myeloma

  • W. M. Kuehl
  • L. A. Brents
  • M. Chesi
  • K. Huppi
  • P. L. Bergsagel
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 224)


Translocation of c-myc to IgH switch regions, or less frequently to one of the IgL loci, is essentially an invariant event in murine plasmacytomas. This results in dysregulation of c-myc, manifested by selective expression of the translocated allele. Human multiple myeloma (MM) has a similarly high incidence of translocations involving IgH switch regions, but c-myc is infrequently involved as a partner in these translocations. However, in screening a panel of 20 MM cell lines, we identified six lines containing two genetically distinguishable c-myc alleles. For these six informative lines (and the corresponding tumor for one line) there is selective expression of one c-myc allele despite the apparent absence of translocation, DNA rearrangement, or amplification involving c-myc. This result suggests frequent tumor specific cis-dysregulation of c-myc in MM by a presently unknown mechanism.


Multiple Myeloma Chromosomal Translocation Lymphoblastoid Cell Line Selective Expression Human Multiple Myeloma 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • W. M. Kuehl
    • 1
  • L. A. Brents
    • 1
  • M. Chesi
    • 1
  • K. Huppi
    • 2
  • P. L. Bergsagel
    • 3
  1. 1.NCI-Navy Medical Oncology BranchBethesdaUSA
  2. 2.Laboratory of GeneticsNCINew YorkUSA
  3. 3.Cornell University Medical CollegeNew YorkUSA

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