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Dysregulation of c-myc in Multiple Myeloma

  • W. M. Kuehl
  • L. A. Brents
  • M. Chesi
  • K. Huppi
  • P. L. Bergsagel
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 224)

Abstract

Translocation of c-myc to IgH switch regions, or less frequently to one of the IgL loci, is essentially an invariant event in murine plasmacytomas. This results in dysregulation of c-myc, manifested by selective expression of the translocated allele. Human multiple myeloma (MM) has a similarly high incidence of translocations involving IgH switch regions, but c-myc is infrequently involved as a partner in these translocations. However, in screening a panel of 20 MM cell lines, we identified six lines containing two genetically distinguishable c-myc alleles. For these six informative lines (and the corresponding tumor for one line) there is selective expression of one c-myc allele despite the apparent absence of translocation, DNA rearrangement, or amplification involving c-myc. This result suggests frequent tumor specific cis-dysregulation of c-myc in MM by a presently unknown mechanism.

Keywords

Multiple Myeloma Chromosomal Translocation Lymphoblastoid Cell Line Selective Expression Human Multiple Myeloma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • W. M. Kuehl
    • 1
  • L. A. Brents
    • 1
  • M. Chesi
    • 1
  • K. Huppi
    • 2
  • P. L. Bergsagel
    • 3
  1. 1.NCI-Navy Medical Oncology BranchBethesdaUSA
  2. 2.Laboratory of GeneticsNCINew YorkUSA
  3. 3.Cornell University Medical CollegeNew YorkUSA

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