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Generation of Immunoglobulin/c-myc Recombinations in Murine Peyer’s Patch Follicles

  • J. R. Müller
  • E. B. Mushinski
  • G. M. Jones
  • J. A. Williams
  • S. Janz
  • P. F. Hausner
  • M. Potter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 224)

Abstract

Plasmacytoma can be induced by the intraperitoneal injection of pristane in susceptible BALB/c mice. Most inbred strains of mice, however, are resistant to this type of plasmacytoma induction (Potter & Wiener, 1992).

Keywords

Inbred Strain Fusion Product Secondary Lymphoid Tissue Resistant Mouse IgHa Locus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Janz S, Müller J, Shaughnessy J, Potter M (1993) Detection of recombinations between c-myc and immunoglobulin switch a in murine plasma cell tumors and preneoplastic lesions by polymerase chain reaction. Proc Natl Acad Sci USA 90: 7361–7365PubMedCentralPubMedCrossRefGoogle Scholar
  2. Müller JR, Potter M, Janz, S (1994) Differences in the molecular structure of c-myc-activating recombinations in murine plasmacytomas and precursor cells. Proc Natl Acad Sci USA 91: 12066–12070PubMedCentralPubMedCrossRefGoogle Scholar
  3. Müller JR, Janz S, Potter M (1995) Differences between Burkitt’s lymphomas and mouse plasmacytomas in the immunoglobulin heavy chain/c-myc recombinations that occur in their chromosomal translocations. Cancer Res 55: 5012–5018PubMedGoogle Scholar
  4. Müller JR, Jones GM, Potter M, Janz S (1996) Detection of immunoglobulin/c-myc recombinations in mice that are resistant to plasmacytoma induction. Cancer Res 56: 419–423PubMedGoogle Scholar
  5. Potter M, Wiener F (1992) Plasmacytomagenesis in mice: model of neoplastic development dependent upon chromosomal translocations. Carcinogenesis 13: 1681–1697PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • J. R. Müller
    • 1
  • E. B. Mushinski
    • 1
  • G. M. Jones
    • 1
  • J. A. Williams
    • 1
  • S. Janz
    • 1
  • P. F. Hausner
    • 1
  • M. Potter
    • 1
  1. 1.Laboratory of Genetics, National Cancer InstituteNational Institutes of HealthBethesdaUSA

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