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Lymphomas and Plasmacytomas in Transgenic Mice Involving Bcl2, Myc and v-Abl

  • A. W. Harris
  • A. Strasser
  • M. L. Bath
  • A. G. Elefanty
  • S. Cory
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 224)

Abstract

During the past twelve years, our laboratory has been analyzing the tumorigenic potential of oncogenes in the lymphoid system of transgenic mice (for reviews see Adams and Cory 1991, 1992). Tissue specific expression of the oncogenes in these animals was achieved by including in the transgene constructs an enhancer sequence (Eμ) from the mouse immunoglobulin heavy chain locus. In most individual strains resulting from the introduction of such constructs, expression was confined to the B lymphoid lineage while a small minority of strains showed expression in both T and B lineages or only in T cells. The pattern for each strain has proved to be stable over many generations of breeding.

Keywords

Follicular Lymphoma Tumor Incidence Lymphoblastic Lymphoma Diffuse Large Cell Lymphoma Composite Lymphoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • A. W. Harris
    • 1
  • A. Strasser
    • 1
  • M. L. Bath
    • 1
  • A. G. Elefanty
    • 1
  • S. Cory
    • 1
  1. 1.The Walter and Eliza Hall Institute of Medical ResearchPO Royal Melbourne HospitalMelbourneAustralia

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