B-lymphocyte-lineage Cells from Early Precursors to Ig-secreting Plasma Cells: Targets of Regulation by the myc/mad/max Families of Genes?
Up- and down-regulation of the expression of c-myc, together or against its partners of the myc/mad/max gene families and the more recently discovered miz-1 (see papers in this volume, in particular Austen et al., Schneider et al., Schreiber-Agus et al.), is thought to control expression of genes involved in the proliferation and differentiation of cells. Very few lineages of cellular development have been studied in vivo and in vitro in comparable detail as B-lineage cells have at many different stages from an early precursor cell to the final stage of an Ig-secreting plasma cell (see [Chen and Alt 1993, Cumano et al 1992, Cumano et al 1994, Decker et al 1991, Era et al 1994, Hardy 1992, Hardy et al 1994, Hayashi et al 1990, Kincade et al 1994, Löffert et al 1994, Nossal 1994, Osmond 1991, Rajewsky 1992, Rolink et al 1994a] for a collection of relevant references). Deregulation of c-myc expression occurs as a consequence of chromosomal translocations to the IgH- and L-chain J segments which are frequently found in human Burkitt’s lymphomas, or to the IgH switch regions which are detected in mineral oil-induced mouse plasmacytomas [Potter and Wiener 1992, Shen-Ong et al 1982]. This signifies the importance of the control of expression of the myc/mad/max-gene families in normal and neoplastic B-lymphocyte development.
KeywordsSecondary Lymphoid Organ Lymphocyte Development preB Cell Early Precursor Cell Chain Allele
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