Association of Myc with the Zinc-finger Protein Miz-1 Defines a Novel Pathway for Gene Regulation by Myc

  • A. Schneider
  • K. Peukert
  • M. Eilers
  • F. Hänel
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 224)


The Myc protein activates transcription as part of a complex with its partner protein, Max. Myc-transformed cells are also characterised by the loss of expression of a number of genes and this repressive effect of Myc on gene expression may not be mediated by the Myc/Max complex. We recently isolated by two-hybrid cloning a novel zinc-finger protein that associates with the carboxy-terminus of Myc. We have termed this protein Miz-1 (Myc-mteracting zinc finger protein). Some of the properties of Miz-1 suggest that it may be involved in gene repression by Myc in vivo.


Zinc Finger Protein Nuclear Import Gene Repression Induce Cell Cycle Progression Small Nuclear Ribonucleoprotein Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • A. Schneider
    • 1
  • K. Peukert
    • 2
  • M. Eilers
    • 1
  • F. Hänel
    • 2
  1. 1.Zentrum für Molekulare Biologie Heidelberg (ZMBH)HeidelbergGermany
  2. 2.Department of Cell and Molecular BiologyHans-Knöll-Institut für Naturstoff-ForschungJenaGermany

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