Association of Myc with the Zinc-finger Protein Miz-1 Defines a Novel Pathway for Gene Regulation by Myc
The Myc protein activates transcription as part of a complex with its partner protein, Max. Myc-transformed cells are also characterised by the loss of expression of a number of genes and this repressive effect of Myc on gene expression may not be mediated by the Myc/Max complex. We recently isolated by two-hybrid cloning a novel zinc-finger protein that associates with the carboxy-terminus of Myc. We have termed this protein Miz-1 (Myc-mteracting zinc finger protein). Some of the properties of Miz-1 suggest that it may be involved in gene repression by Myc in vivo.
KeywordsZinc Finger Protein Nuclear Import Gene Repression Induce Cell Cycle Progression Small Nuclear Ribonucleoprotein Particle
Unable to display preview. Download preview PDF.
- Amati, B., Littlewood, T. D., Evan, G. I., and Land, H. (1993). The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J. 13, 5083–5087.Google Scholar
- Paganin, C, Bianchi, G., Lombardi, L., Dalla Favera, R., Mantovani, A., and Allavena, P. (1994). Role of leukocyte function-associated antigen-1 and very late antigen-4 in the adhesion and transmigration of c-myc-transfected B-lymphoblastoid cell lines across vascular endothelium. Int J Clin Lab Res 24, 29–32.PubMedCrossRefGoogle Scholar
- Penn, L. J. Z., Brooks, M. W., Laufer, E. M., and Land, H. (1990). Negative autoregulation of c-myc transcription. EMBO J. 9, 113–121.Google Scholar