Advertisement

Association of Myc with the Zinc-finger Protein Miz-1 Defines a Novel Pathway for Gene Regulation by Myc

  • A. Schneider
  • K. Peukert
  • M. Eilers
  • F. Hänel
Chapter
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 224)

Summary

The Myc protein activates transcription as part of a complex with its partner protein, Max. Myc-transformed cells are also characterised by the loss of expression of a number of genes and this repressive effect of Myc on gene expression may not be mediated by the Myc/Max complex. We recently isolated by two-hybrid cloning a novel zinc-finger protein that associates with the carboxy-terminus of Myc. We have termed this protein Miz-1 (Myc-mteracting zinc finger protein). Some of the properties of Miz-1 suggest that it may be involved in gene repression by Myc in vivo.

Keywords

Zinc Finger Protein Nuclear Import Gene Repression Induce Cell Cycle Progression Small Nuclear Ribonucleoprotein Particle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Albagli, O., Dhordain, P., Bernardin, F., Quief, S., Kerkaert, J. P., and Leprince, D. (1996). Multiple domains participate in distance-independent LAZ3/BCL6-mediated transcriptional repression. Biochem Biophys Res Commun 220, 911–915.PubMedCrossRefGoogle Scholar
  2. Alexandrova, N., Niklinski, J., Bliskovsky, V., Otterson, G. A., Blake, M., Kaye, F. J., and Zajac Kaye, M. (1995). The N-terminal domain of c-Myc associates with alpha-tubulin and microtubules in vivo and in vitro. Mol. Cell. Biol. 15, 5188–5195.PubMedCentralPubMedGoogle Scholar
  3. Amati, B., Brooks, M. W., Levy, N., Littlewood, T. D., Evan, G. I., and Land, H. (1993). Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell 72, 233–245.PubMedCrossRefGoogle Scholar
  4. Amati, B., Littlewood, T. D., Evan, G. I., and Land, H. (1993). The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J. 13, 5083–5087.Google Scholar
  5. Bardwell, V. J., and Treisman, R. (1994). The POZ domain: A conserved protein-protein interaction motif. Genes Dev. 8, 1664–1677.PubMedCrossRefGoogle Scholar
  6. Bernards, R. (1995). Transcriptional regulation. Flipping the Myc switch. Curr. Biol. 5, 859–561.PubMedCrossRefGoogle Scholar
  7. Craig, R. W., Buchan, H. L., Civin, C. I., and Kastan, M. B. (1993). Altered cytoplasmic/nuclear distribution of the c-myc protein in differentiating ML-1 human myeloid leukemia cells. Cell Growth Differ 4, 349–357.PubMedGoogle Scholar
  8. Dhordain, P., Albagli, O., Ansieau, S., Koken, M. H. M., Deweindt, C, Quief, S., Lantoine, D., Leutz, A., Kerckaert, J.-P., and Leprince, D. (1995). The BTB/POZ domain targets the LAZ3/BCL6 oncoprotein to nuclear dots and mediated homomerisation in vivo. Oncogene 11, 2689–2697.PubMedGoogle Scholar
  9. Flickinger, K. S., Judware, R., Lechner, R., Carter, W. G., and Culp, L. A. (1994). Integrin expression in human neuroblastoma cells with or without N-myc amplification and in ectopic/orthotopic nude mouse tumors. Exp Cell Res 213, 156–163.PubMedCrossRefGoogle Scholar
  10. Freytag, S. O., and Geddes, T. J. (1992). Reciprocal regulation of adipogenesis by Myc and C/EBPα. Science 256, 379–382.PubMedCrossRefGoogle Scholar
  11. Henriksson, M., and Lüscher, B. (1996). Proteins of the Myc network: Essential regulators of cell growth and differentiation. Cancer Research 68, 109–182.CrossRefGoogle Scholar
  12. Inghirami, G., Grignani, F., Sternas, L., Lombardi, L., Knowles, D. M., and Dalla Favera, R. (1990). Down-regulation of LFA-1 adhesion receptors by C-myc oncogene in human B lymphoblastoid cells. Science 250, 682–686.PubMedCrossRefGoogle Scholar
  13. Li, L., Nerlov, C, Prendergast, G., MacGregor, D., and Ziff, E. B. (1994). c-Myc represses transcription in vivo by a novel mechanism dependent on the initiator element and Myc box II. EMBO J. 13, 4070–4079.PubMedCentralPubMedGoogle Scholar
  14. Marhin, W. W., Hei, Y.-J., Chen, S., Jiang, Z., Gallie, B., Phillips, R. A., and Penn, L. Z. (1996). Loss of Rb and Myc activation co-operate to suppress cyclin D1 and contribute to transformation. Oncogene 12, 43–55.PubMedGoogle Scholar
  15. Paganin, C, Bianchi, G., Lombardi, L., Dalla Favera, R., Mantovani, A., and Allavena, P. (1994). Role of leukocyte function-associated antigen-1 and very late antigen-4 in the adhesion and transmigration of c-myc-transfected B-lymphoblastoid cell lines across vascular endothelium. Int J Clin Lab Res 24, 29–32.PubMedCrossRefGoogle Scholar
  16. Penn, L. J. Z., Brooks, M. W., Laufer, E. M., and Land, H. (1990). Negative autoregulation of c-myc transcription. EMBO J. 9, 113–121.Google Scholar
  17. Philipp, A., Schneider, A., Vasrik, I., Finke, K., Xiong, Y., Beach, D., Alitalo, K., and Eilers, M. (1994). Repression of Cyclin D1: a Novel Function of MYC. Mol. Cell. Biol. 14, 4032–4043.PubMedCentralPubMedGoogle Scholar
  18. Roy, A. L., Carruthers, C, Gutjahr, T., and Roeder, R. G. (1993). Direct role for Myc in transcription initiation mediated by interactions with TFII-I. Nature 365, 359–361.PubMedCrossRefGoogle Scholar
  19. Schulz, T. C, Hopwood, B., Rathjen, P. D., and Wells, J. R. E. (1995). An unusual arrangement of 13 zinc fingers in the vertebrate gene Z13. Biochem. J. 311, 219–224.PubMedCentralPubMedGoogle Scholar
  20. Schwab, M., Praml, C, and Amler, L. C. (1996). Genomic instability in 1p and human malignancies. Genes Chromosom Cancer 16, 211–229.PubMedCrossRefGoogle Scholar
  21. Shrivastava, A., Saleque, S., Kalpana, G. V., Artandi, S., Goff, S. P., and Calame, K. (1993). Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc. Science 262, 1889–1891.PubMedCrossRefGoogle Scholar
  22. Spector, D. L., Watt, R. A., and Sullivan, N. F. (1987). The v- and c-myc oncogene proteins colocalize in situ with small nuclear ribonucleoprotein particles. Oncogene 1, 5–12.PubMedGoogle Scholar
  23. Wakamatsu, Y., Watanabe, Y., Shimono, A., and Kondoh, H. (1993). Transition of localization of the N-Myc protein from nucleus to cytoplasm in differentiating neurons. Neuron 10, 1–9.PubMedCrossRefGoogle Scholar
  24. Yang, B. S., Geddes, T. J., Pogulis, R. J., de Crombrugghe, B., and Freytag, S. O. (1991). Transcriptional suppression of cellular gene expression by c-Myc. Mol. Cell Biol. 11, 2291–2295.PubMedCentralPubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • A. Schneider
    • 1
  • K. Peukert
    • 2
  • M. Eilers
    • 1
  • F. Hänel
    • 2
  1. 1.Zentrum für Molekulare Biologie Heidelberg (ZMBH)HeidelbergGermany
  2. 2.Department of Cell and Molecular BiologyHans-Knöll-Institut für Naturstoff-ForschungJenaGermany

Personalised recommendations