C-Myc Transrepression and Cell Transformation
The c-Myc oncoprotein affects cell differentiation, cell proliferation, apoptosis, and cell transformation. Many studies have ultimately centered on the ability of c-Myc to transactivate through the E-box as the mechanism underlying all of these Myc functions. It is so widely accepted that c-Myc transactivation is necessary for cell transformation, that the authentication of putative target genes requires the presence of E-boxes within these genes that can be transactivated by c-Myc in transient transfection assays. However, several examples exist where mutations of c-Myc result in the disassociation of c-Myc transformation from transactivation, suggesting the existence of other mechanisms that confer its transforming properties. Recently, c-Myc mediated transrepression, a poorly understood function of c-Myc, has been the focus of increased interest as several genes have been reported to be down-regulated by c-Myc. Evidence now suggests that transrepression may contribute to cell transformation.
KeywordsCell Transformation Transactivation Domain Putative Target Gene Transient Transfection Assay Initiator Element
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