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C-Myc Transrepression and Cell Transformation

  • L. A. Lee
  • C. V. Dang
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 224)

Abstract

The c-Myc oncoprotein affects cell differentiation, cell proliferation, apoptosis, and cell transformation. Many studies have ultimately centered on the ability of c-Myc to transactivate through the E-box as the mechanism underlying all of these Myc functions. It is so widely accepted that c-Myc transactivation is necessary for cell transformation, that the authentication of putative target genes requires the presence of E-boxes within these genes that can be transactivated by c-Myc in transient transfection assays. However, several examples exist where mutations of c-Myc result in the disassociation of c-Myc transformation from transactivation, suggesting the existence of other mechanisms that confer its transforming properties. Recently, c-Myc mediated transrepression, a poorly understood function of c-Myc, has been the focus of increased interest as several genes have been reported to be down-regulated by c-Myc. Evidence now suggests that transrepression may contribute to cell transformation.

Keywords

Cell Transformation Transactivation Domain Putative Target Gene Transient Transfection Assay Initiator Element 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • L. A. Lee
    • 1
  • C. V. Dang
    • 2
  1. 1.Department of Medicine, The Johns HopkinsUniversity School of MedicineBaltimoreUSA
  2. 2.The Johns Hopkins Oncology Center, The Johns HopkinsUniversity School of MedicineBaltimoreUSA

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